Abstract

Casein kinase I has a wide variety of substrates, with the existence of at least eight isoforms in vertebrate cells, making understanding of regulation somewhat complex and difficult. The enzyme appears to have roles in cell division, DNA repair and glycogen metabolism. CK1 is expressed ubiquitously throughout mammalian tissue and cell lines, although different isofoms show some subcellular localisation within the cytoplasm, nuclei and associated with membranes and the cytoskeleton.