30 Aug 2021 | ELM database updatesIn a huge update, 13 new ELM classesDOC_CDC14_PxL_1 DOC_CYCLIN_yClb3_PxF_3 DOC_MIT_MIM_1 LIG_Integrin_KxxGD_FGGC_5 LIG_RuBisCO_WRxxL_1 LIG_SH3_CIN85_PxpxPR_1 MOD_CDC14_SPxK_1 TRG_DiLeu_BaEn_1 TRG_DiLeu_BaEn_2 TRG_DiLeu_BaEn_3 TRG_DiLeu_BaEn_4 TRG_DiLeu_BaLyEn_6 TRG_DiLeu_LyEn_5 have been added and two LIG_LIR_Gen_1 LIG_LIR_Nem_3 have been revised. Two entries TRG_LysEnd_APsAcLL_1 and TRG_LysEnd_APsAcLL_3 have been deleted. |
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21 Jul 2021 | ELM database updatesIn another major addition, Seven new classes DEG_SCF_FBXO31_1, DOC_CYCLIN_yClb1_LxF_4, LIG_ActinCP_CPI_1, LIG_ActinCP_TwfCPI_2, LIG_Integrin_RGD_TGFbeta-like_3, LIG_Integrin_RGDW_4, and LIG_WRC_WIRS_1 have been released.A total of 80 instances belonging to these classes have been inserted. |
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01 Jul 2021 | ELM database updatesIn this major release, four new classes DOC_CYCLIN_D_Helix_1, DOC_CYCLIN_yCln2_LP_2, LIG_LYPXL_SIV_4 and LIG_LYPXL_yS_3 have been added. Two classes LIG_LYPXL_S_1, LIG_LYPXL_L_2 have been revised. |
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19 May 2021 | ELM database updatesTwo new ELM classes LIG_LSD1_SNAG_1 and LIG_KLC1_Yacidic_2 have been added. Major addition of 40 new instances along with updates in the existing instances of ELM class LIG_LIR_Gen_1. |
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21 Apr 2021 | ELM database updatesTwo new ELM classes LIG_DLG_GKlike_1 and DOC_CYCLIN_yClb5_NLxxxL_5 have been added. |
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15 Oct 2020 | ELM database updateTwo new classes addedLIG_NRP_CendR_1 LIG_PCNA_TLS_4 |
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09 Aug 2019 | ELM database updatesNew ELM classes and their instances have been added:LIG_deltaCOP1_diTrp_1 LIG_FXI_DFP_1 LIG_MLH1_MIPbox_1 TRG_Pf-PMV_PEXEL_1 |
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28 Aug 2018 | ELM database updateAdded 9 new instances for DOC_CYCLIN_RxL_1 |
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02 Aug 2018 | ELM database updateAdded a new motif: LIG_PROFILIN_1,and new instances for MOD_CAAXbox and MOD_CDK_SPxK_1 |
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06 Aug 2018 | ELM database updateUpdated the motif DOC_CYCLIN_RxL_1 and 19 motif instances |
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26 Jun 2018 | ELM database update22 New Fungal instances added for MOD_Plk_1 |
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27 Jun 2017 | ELM database updateNew instances added for LIG_Vh1_VBS_1 |
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21 Nov 2016 | ELM Database UpdateWe have updated several MOD_CDK motifs and added new instances:MOD_CDK_1 is now: MOD_CDK_SPxK_1, and MOD_CDK_SPK_2 MOD_CDK_SPxxxK_3 have been added. |
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11 Nov 2016 | ELM database updateSeveral new ELM classes and instances have been added:LIG_BH_BH3_1 DEG_COP1_1 |
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24 Oct 2016 | ELM database updateThe class DOC_PP2A_KARD_1 has been replaced by DOC_PP2A_B56_1, and new instances have been added. |
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16 Mar 2017 | <span style="color:orange">Just published in Science Signaling: A review on <a href="https://dx.doi.org/10.1126/scisignal.aak9982" >Degrons in Cancer</a></span> |
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19 Sep 2016 | ELM database updateSeveral new ELM classes and instances have been added:LIG_CSK_EPIYA_1 LIG_Rb_LxCxE_1 DOC_MAPK_JIP1_4 DOC_MAPK_NFAT4_5 |
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21 Jun 2016 | ELM database updateSeveral new ELM classes and instances have been added:DOC_MAPK_RevD_3 LIG_ANK_PxLPxL_1 LIG_CSL_BTD_1 LIG_G3BP_FGDF_1 LIG_KLC1_TPR_1 LIG_PALB2_WD40_1 LIG_UFM1_UFIM_1 These ELM classes have been updated: LIG_Mtr4_Trf4_2 LIG_Pex14_4 LIG_LIR_Apic_2 LIG_APCC_Cbox_2 LIG_APCC_Cbox_1 LIG_SUMO_SIM_par_1 LIG_CAP-Gly_2 DOC_MAPK_FxFP_2 DOC_MAPK_gen_1 CLV_PCSK_KEX2_1 |
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21 Jun 2016 | ELM classes 14-3-3 have been mergedSome of the oldest entries in the database have been updated. They had been proven to be difficult and it took quite an effort to sort these out. Finally, we can announce that the classesLIG_14-3-3_1 and LIG_14-3-3_2 have been merged into LIG_14-3-3_CanoR_1, LIG_14-3-3_3 has been dropped and a C-terminal class has been added: LIG_14-3-3_CterR_2 |
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14 Oct 2016 | <span style="color:orange"><b>New graduate opportunities in the PDZnet Training Network!</b></span> <a href="http://pdznet.eu" >Find out more</a>
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30 Nov 2015 | ELM update paper publishedAll the latest updates and improvements have been written up in the latest ELM paper (26615199) |
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02 Nov 2015 | ELM database updateThe following elm classes have been added to the database:LIG_GSK3_LRP6_1 LIG_FZD_DVL_PDZ LIG_LRP6_Inhibitor_1 LIG_DCNL_PONY_1 LIG_UBA3_1 DOC_USP7_UBL2_3 Many new instances & interactions have been added, too. |
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14 Aug 2015 | ELM database updateThe following elm classes have been added to the database:DEG_Kelch_actinfilin_1, DEG_Kelch_Keap1_1, DEG_Kelch_Keap1_2, DEG_Kelch_KLHL3_1, DEG_Nend_Nbox_1, DEG_Nend_UBRbox_1, DEG_Nend_UBRbox_2, DEG_Nend_UBRbox_3, DEG_Nend_UBRbox_4, DEG_SPOP_SBC_1, DOC_GSK3_Axin_1, LIG_CID_NIM_1, LIG_GBD_WASP_1, LIG_Mtr4_Air2_1, LIG_Mtr4_Trf4_1, LIG_Mtr4_Trf4_2, LIG_Pex14_3, LIG_Pex14_4, LIG_RPA_C_Fungi, LIG_RPA_C_Insects, LIG_RPA_C_Plants, LIG_RPA_C_Vert, MOD_SUMO_rev_2 Many new instances & interactions have been added, too. |
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10 Feb 2015 | ELM database update:The following ELM classes have been added: DOC_PP1_MyPhoNE_1 DOC_PP2A_KARD_1 LIG_CNOT1_NIM_1and two ELM classes have been updated/renamed: LIG_SUMO_SIM_par_1 LIG_SUMO_SIM_anti_2 Furthermore, more than 100 instances have been added to the database. |
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13 Jan 2014 | ELM database updateA new ELM class has been annotated: LIG_CaMK_CASK_1Also, many new experimental instances have been added. |
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22 May 2014 | ELM database update:The following ELM classes have been added:LIG_EF_ALG2_ABM_2 LIG_EF_ALG2_ABM_1 LIG_LIR_LC3C_4 LIG_LIR_Nem_3 LIG_LIR_Apic_2 LIG_LIR_Gen_1 DOC_PP2B_2 LIG_WD40_WDR5_2 LIG_WD40_WDR5_1 LIG_WD40_WDR5_WIN_3 LIG_WD40_WDR5_WIN_2 LIG_WD40_WDR5_WIN_1 DOC_PP1_SILK_1 LIG_SUFU_1 DOC_CKS1_1 The following ELM classes have been updated: TRG_LysEnd_GGAAcLL_2 DOC_PP2B_1 DOC_PP1_RVXF_1 LIG_GBD_WASP_1 CLV_PCSK_SKI1_1 CLV_C14_Caspase3-7 CLV_PCSK_FUR_1 CLV_PCSK_KEX2_1 CLV_PCSK_PC1ET2_1 CLV_PCSK_PC7_1 CLV_MEL_PAP_1 CLV_Separin_Fungi CLV_Separin_Metazoa CLV_NRD_NRD_1 Furthermore, more than 100 instances have been added to the database. |
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19 Nov 2013 | ELM update paper publishedAll the latest updates and improvements have been written up in the latest ELM paper (24214962) |
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03 Sep 2013 | Docking classes renamedA new ELM subtype (DOC) representing degradation sites has been created and the following classes have been renamed:
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26 Aug 2013 | Interactions as downloads availableInteractions between ELM instances and interaction domains can be viewed in the elm_instances pages, but also downloaded as either PSI MITAB or PSI-MI XML (2.5) format. See also the "ELM internal links" in the Links page |
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26 Aug 2013 | Degron classes renamedA new ELM subtype (DEG) representing degradation sites has been created and more than ten classes have been renamed: |
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15 Aug 2013 | Links to Switches.ELM addedEach ELM instance which is part of a switching mechanism annotated at http://switches.elm.eu.org/ is provided with a short description of this mechanism as well as a schematic and links to the corresponding entry at Switches.ELM. |
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15 Aug 2013 | ELM database updateThe ELM classes LIG_SCF_TIR1_1, LIG_SCF_COI1_1, LIG_NBox_RRM_1, LIG_APCC_Cbox_1 and LIG_APCC_Cbox_2 as well as instances for each class have been added to the database. |
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28 Jun 2013 | ELM database updateThe ELM classes LIG_APCC_TPR_1 and LIG_PAM2_2 have been added to the database and LIG_MYND has been split into multiple classes: LIG_MYND_1, LIG_MYND_2, and LIG_MYND_3. Furthermore, ELM class LIG_EVH1_1 has been updated, and several new Instances have been added to the database. |
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18 Jan 2013 | ELM database updateNew classes have been added: CLV_Separin_Fungi, CLV_Separin_Metazoa, LIG_SUMO_SBM_1, LIG_SUMO_SBM_2, MOD_LATS_1, TRG_PEX_2, and TRG_PEX_3 and the following classes have been updated: LIG_Integrin_isoDGR_1, LIG_PCNA_PIPBox_1, and TRG_PEX_1.Many new Instances have been added to the database and links to external resources have been updated. Furthermore, information about interaction partners is shown at the instance detail page (where available). |
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01 Aug 2012 | ELM database updateOne new ELM class has been annotated (LIG_SPRY_1) and existing ones have been updated:LIG_Integrin_isoDGR_1, TRG_PEX_1, LIG_Integrin_isoDGR_1, LIG_PCNA_PIPBox_1, LIG_CRL4_CDT2_1, LIG_CTBP_PxDLS_1. Many new instances have been added to the database... |
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11 Apr 2012 | ELM database updateOne new ELM class has been annotated (LIG_OCRL_FandH_1) and existing ones have been updated:LIG_14-3-3_3, LIG_PP1, LIG_TNKBM_1, LIG_WW_PIN1_4, MOD_TYR_ITAM, TRG_ER_diArg_1, and TRG_LysEnd_APsAcLL_1 |
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02 Dec 2011 | ELM update paper publishedAll the latest updates and improvements have been written up in the latest ELM paper (![]() |
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02 Dec 2011 | ELM database updateNew ELM classes have been annotated:LIG_CAP-Gly_2, LIG_CRL4_CDT2_2, LIG_CRL4_CDT2_1, LIG_SCF_SKP2-CKS1_1, and CLV_C14_Caspase3-7 |
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09 Nov 2011 | ELM sequences updateSequences of annotated ELM instances have been synced with UNIPROT.Instance positions were mapped onto new sequences. |
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16 Oct 2011 | ELM database update
New ELM classes have been annotated: |
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13 Sep 2011 | Re-Mapping of annotated experimental methodsAll experimental methods have been updated and synced to PSI:MI controlled vocabulary (where possible) |
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05 Sep 2011 | New ELM Web InterfaceThe ELM resource got a new web interface:All HTML pages are now dynamically created using the python framework DJANGO; JavaScript is used to make the whole site more interactive and to communicate to the server via AJAX callbacks. The whole website was redesigned introducing many new features such as full-text search for ELM classes as well as instances. |
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25 Aug 2011 | ELM database updateNew ELM classes have been annotated:LIG_EVH1_3, LIG_Actin_RPEL_3, LIG_Actin_WH2_2, LIG_Actin_WH2_1, LIG_AGCK_PIF_3, LIG_AGCK_PIF_2, LIG_AGCK_PIF_1, LIG_PAM2_1. |
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20 Dec 2010 | ELM database updateThe list of ELM classes has been updated.New entries: LIG_BIR_III_4, LIG_FAT_LD_1, LIG_HCF-1_HBM_1, LIG_LYPXL_L_2, LIG_LYPXL_S_1, LIG_RB_pABgroove_1 and LIG_SPAK-OSR1_1 Also, many new experimental instances have been added. |
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08 Feb 2010 | ELM database updateThe list of ELM motif classes has been updated.New entries: LIG_BIR, LIG_GLEBS_BUB3, LIG_SCF-TrCP1, LIG_SCF_FBW7, LIG_SxIP_EBH, TRG_Cilium_Arf4, TRG_Cilium_RVxP, TRG_ER_FFAT, TRG_NLS_Bipartite, TRG_NLS_MonoCore, TRG_NLS_MonoExtC, and TRG_NLS_MonoExtN More than 100 new experimental instances have been added. |
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02 Feb 2010 | New ELM candidate motif pageWe have created a page listing unannotated candidate motifs that might become ELM entries with your help. Please, feel free to browse this page and to annotate ELM with us. |
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04 Dec 2009 | ELM Update imminentThe new ELM paper is out! New data and new motif entries are being finalised and will be added shortly to the ELM database. |
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08 Apr 2009 | ELM Database UpdateNew entries for KEPE motifs. Also modifications to some existing entries e.g. 14-3-3 ligand motifs. |
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02 Apr 2009 | ELM Structure Filter 1.1 addedAdditional functionality added. A p-value is assigned to each score of an ELM match. These p-values provide a conservative estimate of the probability that an ELM prediction with a given score is a true positive. |
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19 Dec 2008 | ELM Structure Filter 1.0 addedRevised scoring scheme with better discrimination power, based on the non-wildcard positions of the linear motifs. |
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07 Nov 2008 | ELM Database UpdateNew entries for Raptor, VHL, AP-2, TRF binder motifs. Also many mods to existing entries with new instances, improvements or corrections e.g. EH, Dbox. Inappropriate PIP2-binding structural motifs deleted. |
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01 May 2008 | Linear Motif Review availableGet the open access linear motif review from FBS now |
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12 Feb 2008 | ELM Structural Filter (BETA version) addedThe ELM Structural Filter evaluates the context of linear motifs lying within the query sequence, whenever a globular domain structure is available (≥70% similarity to the query sequence).The filter scores both the secondary structure overlap and the accessibility of the individual residues of each motif. |
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13 Dec 2007 | ELM Database UpdateNew entries for PP2B, CAP-GLY, USP7, SIah. Experimental instances added to some existing entries e.g.PP1. |
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09 May 2007 | ELM Database UpdateSubstantial update to the ELM database. Fixes to many existing entries. More than 10 new motif patterns e.g. NES, Destruction Boxes, MAP kinase docking motifs. |
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26 Oct 2006 | ELM Database Web Service AvailableAs part of the EMBRACE project to integrate various European Bioinformatics resources, protein motif data stored in the ELM database can now be directly accessed through a Web Services schema. Users interested in using the WS are requested to contact the ELM Webmaster |
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24 Jun 2005 | ELM instance mapper addedThe ELM instance mapper allow the identification of known experimental ELM instances in query sequences if annotated in the ELM resource.Additionally, predictions in sequences similar to annotated ELM instance sequences will be scored, if the motif position is conserved. |
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25 Jun 2003 | ELM paper is outELM server: a new resource for investigating short functional sites in modular eukaryotic proteins.Puntervoll, P., Linding, R., Gemünd, C., Chabanis-Davidson, S., Mattingsdal, M., Cameron, S., Martin, D. M. A., Ausiello, G., Brannetti, B., Costantini, A., Ferrè, F., Maselli, V., Via, A., Cesareni, G., Diella, F., Superti-Furga, G., Wyrwicz, L., Ramu, C., McGuigan, C., Gudavalli, R., Letunic, I., Bork, P., Rychlewski, L., Küster, B., Helmer-Citterich, M., Hunter, W. N., Aasland, R., & Gibson, T. J. (2003). Nucleic Acids Res., 31: 3625-3630. |
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement