SEARCH the ELM database

The ELM relational database stores different types of data about experimentally validated SLiMs that are manually curated from the literature. ELM instances are classified by motif type, functional site and ELM class. A functional site contains one to many ELM classes, which are described by a regular expression and list experimentally validated motif instances matching this sequence pattern. All data curated in ELM DB can be searched on the ELM website according to the following categories:

• 353 annotated ELM classes
• 4,277 experimentally validated ELM instances in 278 taxons
• 148 ELM methods described in 4,283 articles to experimentally validate ELM instances
• 722 solved PDB structures for curated ELM instances (from PDB)
• 190 globular ELM binding domains (from Pfam, SMART, and InterPro)
• 2,797 interactions mediated by curated ELM instances
• 887 regulatory switches mediated by curated ELM instances (from Switches.ELM DB)
• 1,063 pathways from KEGG involving linear motifs annotated in 1297 Sequences
• 293 viral instances interfering with host cellular processes
• 11 ELM related diseases annotated as being caused by aberrant motif function
• 2 examples where pathogens abuse motifs to deregulate host cells