| Accession: | |
|---|---|
| Functional site class: | WRPW motif |
| Functional site description: | The WRPW motif mediates co-repressor recruitment. |
| ELMs with same func. site: | LIG_WRPW_1 LIG_WRPW_2 |
| ELM Description: | The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_1 is based on the C-terminus located motifs found in the Hairy and Runt family proteins. |
| Pattern: | [WFY]RP[WFY].{0,7}$ |
| Pattern Probability: | 1.333e-07 |
| Present in taxon: | Metazoa |
| Interaction Domain: |
WD40 (PF00400)
WD domain, G-beta repeat
(Stochiometry: 1 : 1)
|
 Abstract |
The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family, and has been identified in the Hairy family of basic-helix-loop-helix (bHLH) domain-containing proteins and the Runt family proteins (WRPY) (Paroush,1994; Fisher,1996; Grbavec,1996; Courey,2001). In these two protein families, the motif is situated at (or near) the C-terminus. Additional Groucho-binding motifs not restricted to the C-terminus are: FRPW in Huckebein (Drosophila) near the N-terminus (Goldstein,1999), and FKPY in Brinker (Drosophila) (Zhang,2001). |
5 selected references:
7 GO-Terms:
20 Instances for LIG_WRPW_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement