The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Functional site class:
SH2 ligand
Functional site description:
Src Homology 2 (SH2) domains recognize small motifs containing a phosphorylated Tyrosine residue.
ELMs with same func. site: LIG_SH2_GRB2  LIG_SH2_PTP2  LIG_SH2_SRC  LIG_SH2_STAT3  LIG_SH2_STAT5  LIG_SH2_STAT6 
ELM Description:
YXXQ motif found in the cytoplasmic region of cytokine receptors that bind STAT3 SH2 domain; a cytokine receptor might contain more YXXQ motif in its cytoplasmic region.
Pattern: (Y)..Q
Pattern Probability: 0.0007975
Present in taxons: Homo sapiens Metazoa
Interaction Domain:
SH2 (PF00017) SH2 domain (Stochiometry: 1 : 1)
o See 9 Instances for LIG_SH2_STAT3
o Abstract
Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signaling pathways. They are able to bind specific motifs containing a phopshorylated tyrosine residue, propagating the signal downstream promoting protein-protein interaction and/or modifying enzymatic activities. Different families of SH2 domains may have different binding specifity, which is usually determined by few residues C-terminal with respect to the pY (positions +1, +2 and +3. Non-phosphorylated peptides do not bind to the SH2 domains. At least three different binding motifs are known: pYEEI (Src-family SH2 domains), pY[IV].[VILP] (SH-PTP2, phospholipase C-gamma), pY.[EN] (GRB2). The interaction between SH2 domains and their substrates is however dependent also to cooperative contacts of other surface regions.
o 6 selected references:

o 2 GO-Terms:

o 9 Instances for LIG_SH2_STAT3
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
72 75 NVNIQTSTYLPQNAATNLNS TP 2 Herpesvirus saimiri (strain 484-77)
P48356 Lepr
1138 1141 TSGENFVPYMPQFQTCSTHS U 0 Mus musculus (House mouse)
P40189 IL6ST
915 918 EGMPKSYLPQTVRQGGYMPQ U 0 Homo sapiens (Human)
P40189 IL6ST
905 908 TDEGMPKSYLPQTVRQGGYM U 0 Homo sapiens (Human)
P40189 IL6ST
814 817 DGILPRQQYFKQNCSQHESS U 0 Homo sapiens (Human)
P40189 IL6ST
767 770 YSTVVHSGYRHQVPSVQVFS U 0 Homo sapiens (Human)
P40223 Csf3r
728 731 SLPALVQAYVLQGDPREISN U 0 Mus musculus (House mouse)
P40238 MPL
631 634 CCTTHIANHSYLPLSYWQQP U 0 Homo sapiens (Human)
Q99062 CSF3R
727 730 GLPTLVQTYVLQGDPRAVST TP 1 Homo sapiens (Human)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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