ELM - Interaction Domains

export as: tsv

409 interaction domains annotated in ELM

ELM identifier	Interaction Domain Id	Interaction Domain Name	Interaction Domain Description
CLV_NRD_NRD_1	PF00675	Peptidase_M16	Insulinase (Peptidase family M16)
CLV_PCSK_FUR_1	PF00082	Peptidase_S8	Subtilase family
CLV_PCSK_PC1ET2_1	PF00082	Peptidase_S8	Subtilase family
CLV_PCSK_PC7_1	PF00082	Peptidase_S8	Subtilase family
CLV_PCSK_SKI1_1	PF00082	Peptidase_S8	Subtilase family
CLV_TASPASE1	PF01112	Asparaginase_2	Asparaginase
old_LIG_14-3-3_1	PF00244	14-3-3	14-3-3 protein
old_LIG_14-3-3_2	PF00244	14-3-3	14-3-3 protein
old_LIG_14-3-3_3	PF00244	14-3-3	14-3-3 protein
LIG_AP_GAE_1	PF02883	Alpha_adaptinC2	Adaptin C-terminal domain
LIG_AP2alpha_1	PF02296	Alpha_adaptin_C	Alpha adaptin AP2, C-terminal domain
LIG_AP2alpha_2	PF02296	Alpha_adaptin_C	Alpha adaptin AP2, C-terminal domain
DEG_APCC_DBOX_1	PF00400	WD40	WD domain, G-beta repeat
DEG_APCC_KENBOX_2	PF00400	WD40	WD domain, G-beta repeat
LIG_BIR_II_1	PF00653	BIR	Inhibitor of Apoptosis domain
LIG_BIR_III_1	PF00653	BIR	Inhibitor of Apoptosis domain
LIG_BIR_III_2	PF00653	BIR	Inhibitor of Apoptosis domain
LIG_BIR_III_3	PF00653	BIR	Inhibitor of Apoptosis domain
LIG_BIR_III_4	PF00653	BIR	Inhibitor of Apoptosis domain
LIG_BRCT_BRCA1_1	PF00533	BRCT	BRCA1 C Terminus (BRCT) domain
LIG_BRCT_BRCA1_2	PF00533	BRCT	BRCA1 C Terminus (BRCT) domain
LIG_BRCT_MDC1_1	PF00533	BRCT	BRCA1 C Terminus (BRCT) domain
LIG_CAP-Gly_1	PF01302	CAP_GLY	CAP-Gly domain
LIG_Clathr_ClatBox_1	PF01394	Clathrin_propel	Clathrin propeller repeat
LIG_Clathr_ClatBox_2	PF01394	Clathrin_propel	Clathrin propeller repeat
DEG_COP1	PF00400	WD40	WD domain, G-beta repeat
LIG_CORNRBOX	PF00104	Hormone_recep	Ligand-binding domain of nuclear hormone receptor
LIG_CtBP_PxDLS_1	PF00389	2-Hacid_dh	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
LIG_Dynein_DLC8_1	PF01221	Dynein_light	Dynein light chain type 1
LIG_EH1_1	PF00400	WD40	WD domain, G-beta repeat
LIG_FAT_LD_1	PF03623	Focal_AT	Focal adhesion targeting region
LIG_FHA_1	PF00498	FHA	FHA domain
LIG_FHA_2	PF00498	FHA	FHA domain
LIG_GLEBS_BUB3_1	PF00400	WD40	WD domain, G-beta repeat
LIG_GYF	PF02213	GYF	GYF domain
LIG_HOMEOBOX	PF00046	Homeobox	Homeobox domain
LIG_HP1_1	PF01393	Chromo_shadow	Chromo shadow domain
LIG_Integrin_collagen_1	PF00092	VWA	von Willebrand factor type A domain
LIG_CaM_IQ_9	PF00036	efhand	EF hand
LIG_LYPXL_L_2	PF13949	ALIX_LYPXL_bnd	ALIX V-shaped domain binding to HIV
LIG_LYPXL_S_1	PF13949	ALIX_LYPXL_bnd	ALIX V-shaped domain binding to HIV
LIG_MAD2	PF02301	HORMA	HORMA domain
DOC_MAPK_gen_1	PF00069	Pkinase	Protein kinase domain
DOC_MAPK_FxFP_2	PF00069	Pkinase	Protein kinase domain
DEG_MDM2_SWIB_1	PF02201	SWIB	SWIB/MDM2 domain
LIG_MYND_1	PF01753	zf-MYND	MYND finger
LIG_NRBOX	PF00104	Hormone_recep	Ligand-binding domain of nuclear hormone receptor
DEG_ODPH_VHL_1	PF01847	VHL	von Hippel-Lindau disease tumour suppressor protein
LIG_PCNA_PIPBox_1	PF02747	PCNA_C	Proliferating cell nuclear antigen, C-terminal domain
LIG_PDZ_Class_1	PF00595	PDZ	PDZ domain (Also known as DHR or GLGF)
LIG_PDZ_Class_2	PF00595	PDZ	PDZ domain (Also known as DHR or GLGF)
LIG_PDZ_Class_3	PF00595	PDZ	PDZ domain (Also known as DHR or GLGF)
DOC_PP1_RVXF_1	PF00149	Metallophos	Calcineurin-like phosphoesterase
DOC_PP2B_PxIxIT_1	PF00149	Metallophos	Calcineurin-like phosphoesterase
LIG_PTAP_UEV_1	PF05743	UEV	UEV domain
LIG_PTB_Phospho_1	PF02174	IRS	PTB domain (IRS-1 type)
LIG_PTB_Phospho_1	PF00640	PID	Phosphotyrosine interaction domain (PTB/PID)
LIG_PTB_Phospho_1	PF08416	PTB	Phosphotyrosine-binding domain
LIG_PTB_Phospho_1	PF10480	ICAP-1_inte_bdg	Beta-1 integrin binding protein
LIG_PTB_Apo_2	PF00640	PID	Phosphotyrosine interaction domain (PTB/PID)
LIG_PTB_Apo_2	PF02174	IRS	PTB domain (IRS-1 type)
DOC_WD40_RPTOR_TOS_1	PF00400	WD40	WD domain, G-beta repeat
LIG_RB_LxCxE_1	PF01857	RB_B	Retinoblastoma-associated protein B domain
LIG_RRM_PRI_1	PF10378	RRM	Putative RRM domain
DEG_SCF_FBW7_1	PF00400	WD40	WD domain, G-beta repeat
DEG_SCF_FBW7_2	PF00400	WD40	WD domain, G-beta repeat
DEG_SCF_TRCP1_1	PF00400	WD40	WD domain, G-beta repeat
LIG_SH2_GRB2like	PF00017	SH2	SH2 domain
LIG_SH2_PTP2	PF00017	SH2	SH2 domain
LIG_SH2_SFK_2	PF00017	SH2	SH2 domain
LIG_SH2_STAT3	PF00017	SH2	SH2 domain
LIG_SH2_STAT5	PF00017	SH2	SH2 domain
LIG_SH2_STAT6	PF00017	SH2	SH2 domain
LIG_SH3_1	PF00018	SH3_1	SH3 domain
LIG_SH3_2	PF00018	SH3_1	SH3 domain
LIG_SH3_3	PF00018	SH3_1	SH3 domain
LIG_SH3_4	PF00018	SH3_1	SH3 domain
LIG_SH3_PxxDY_5	PF00018	SH3_1	SH3 domain
DEG_SIAH_1	PF03145	Sina	Seven in absentia protein family
LIG_Sin3_1	PF02671	PAH	Paired amphipathic helix repeat
LIG_Sin3_2	PF02671	PAH	Paired amphipathic helix repeat
LIG_Sin3_3	PF02671	PAH	Paired amphipathic helix repeat
DOC_SPAK_OSR1_1	PF12202	OSR1_C	Oxidative-stress-responsive kinase 1 C terminal
LIG_SxIP_EBH_1	PF03271	EB1	EB1-like C-terminal motif
DOC_ANK_TNKS_1	PF00023	Ank	Ankyrin repeat
LIG_TPR	PF00515	TPR_1	Tetratricopeptide repeat
LIG_TRAF2like_MATH_shPxQ_1	PF00917	MATH	MATH domain
LIG_TRAF2like_MATH_loPxQ_2	PF00917	MATH	MATH domain
LIG_TRAF6_MATH_1	PF00917	MATH	MATH domain
LIG_TRFH_1	PF08558	TRF	Telomere repeat binding factor (TRF)
LIG_ULM_U2AF65_1	PF00076	RRM_1	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DOC_USP7_MATH_1	PF00917	MATH	MATH domain
DOC_USP7_MATH_2	PF00917	MATH	MATH domain
LIG_WH1	PF00568	WH1	WH1 domain
LIG_WRPW_1	PF00400	WD40	WD domain, G-beta repeat
LIG_WRPW_2	PF00400	WD40	WD domain, G-beta repeat
LIG_WW_1	PF00397	WW	WW domain
LIG_WW_2	PF00397	WW	WW domain
LIG_WW_3	PF00397	WW	WW domain
DOC_WW_Pin1_4	PF00397	WW	WW domain
MOD_CAAXbox	PF01239	PPTA	Protein prenyltransferase alpha subunit repeat
MOD_CK1_1	PF00069	Pkinase	Protein kinase domain
MOD_CK2_1	PF00069	Pkinase	Protein kinase domain
MOD_CMANNOS	PF00535	Glycos_transf_2	Glycosyl transferase family 2
MOD_GSK3_1	PF00069	Pkinase	Protein kinase domain
MOD_N-GLC_1	PF02516	STT3	Oligosaccharyl transferase STT3 subunit
MOD_N-GLC_2	PF02516	STT3	Oligosaccharyl transferase STT3 subunit
MOD_OFUCOSY	PF10250	O-FucT	GDP-fucose protein O-fucosyltransferase
MOD_OGLYCOS	PF02709	Galactosyl_T_2	Galactosyltransferase
MOD_PIKK_1	PF00454	PI3_PI4_kinase	Phosphatidylinositol 3- and 4-kinase
MOD_PKB_1	PF00069	Pkinase	Protein kinase domain
MOD_PLK	PF00069	Pkinase	Protein kinase domain
MOD_SPalmitoyl_2	PF01529	zf-DHHC	DHHC zinc finger domain
MOD_SPalmitoyl_4	PF01529	zf-DHHC	DHHC zinc finger domain
MOD_SUMO_for_1	PF00179	UQ_con	Ubiquitin-conjugating enzyme
MOD_TYR_CSK	PF07714	Pkinase_Tyr	Protein tyrosine kinase
MOD_TYR_DYR	PF00069	Pkinase	Protein kinase domain
LIG_TYR_ITAM	PF00017	SH2	SH2 domain
LIG_TYR_ITIM	PF00017	SH2	SH2 domain
MOD_WntLipid	PF03062	MBOAT	MBOAT family
TRG_AP2beta_CARGO_1	PF09066	B2-adapt-app_C	Beta2-adaptin appendage, C-terminal sub-domain
TRG_Cilium_Arf4_1	PF00025	Arf	ADP-ribosylation factor family
TRG_ENDOCYTIC_2	PF00928	Adap_comp_sub	Adaptor complexes medium subunit family
TRG_ER_FFAT_1	PF00635	Motile_Sperm	MSP (Major sperm protein) domain
TRG_ER_KDEL_1	PF00810	ER_lumen_recept	ER lumen protein retaining receptor
TRG_Golgi_diPhe_1	PF00400	WD40	WD domain, G-beta repeat
TRG_LysEnd_APsAcLL_1	PF01217	Clat_adaptor_s	Clathrin adaptor complex small chain
TRG_LysEnd_APsAcLL_3	PF01217	Clat_adaptor_s	Clathrin adaptor complex small chain
TRG_LysEnd_GGAAcLL_1	PF00790	VHS	VHS domain
TRG_LysEnd_GGAAcLL_2	PF00790	VHS	VHS domain
TRG_NES_CRM1_1	PF08389	Xpo1	Exportin 1-like protein
TRG_NLS_Bipartite_1	PF00514	Arm	Armadillo/beta-catenin-like repeat
TRG_NLS_MonoCore_2	PF00514	Arm	Armadillo/beta-catenin-like repeat
TRG_NLS_MonoExtC_3	PF00514	Arm	Armadillo/beta-catenin-like repeat
TRG_NLS_MonoExtN_4	PF00514	Arm	Armadillo/beta-catenin-like repeat
LIG_Pex14_1	PF00018	SH3_1	SH3 domain
TRG_PTS1	PF00515	TPR_1	Tetratricopeptide repeat
TRG_PTS2	PF00400	WD40	WD domain, G-beta repeat
DEG_SCF_SKP2-CKS1_1	PF00560	LRR_1	Leucine-rich repeat
LIG_Actin_RPEL_3	PF00022	Actin	Actin
LIG_Actin_WH2_1	PF00022	Actin	Actin
LIG_Actin_WH2_2	PF00022	Actin	Actin
DOC_AGCK_PIF_1	PF00069	Pkinase	Protein kinase domain
DOC_AGCK_PIF_2	PF00069	Pkinase	Protein kinase domain
DOC_AGCK_PIF_3	PF00069	Pkinase	Protein kinase domain
LIG_EH_1	PF00036	efhand	EF hand
LIG_EVH1_1	PF00568	WH1	WH1 domain
LIG_EVH1_2	PF00568	WH1	WH1 domain
LIG_EVH1_3	PF00568	WH1	WH1 domain
LIG_RB_pABgroove_1	PF01857	RB_B	Retinoblastoma-associated protein B domain
LIG_RB_pABgroove_1	PF01858	RB_A	Retinoblastoma-associated protein A domain
LIG_Integrin_RGD_1	PF00362	Integrin_beta	Integrin, beta chain
LIG_Integrin_RGD_1	PF01839	FG-GAP	FG-GAP repeat
MOD_ASX_betaOH_EGF	PF05118	Asp_Arg_Hydrox	Aspartyl/Asparaginyl beta-hydroxylase
MOD_CDK_SPxK_1	PF00069	Pkinase	Protein kinase domain
MOD_Cter_Amidation	PF01082	Cu2_monooxygen	Copper type II ascorbate-dependent monooxygenase, N-terminal domain
MOD_GlcNHglycan	PF02485	Branch	Core-2/I-Branching enzyme
MOD_GlcNHglycan	PF01048	PNP_UDP_1	Phosphorylase superfamily
MOD_NMyristoyl	PF02799	NMT_C	Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
MOD_PK_1	PF00069	Pkinase	Protein kinase domain
MOD_PKA_1	PF00069	Pkinase	Protein kinase domain
MOD_PKA_2	PF00069	Pkinase	Protein kinase domain
MOD_ProDKin_1	PF00069	Pkinase	Protein kinase domain
LIG_TYR_ITSM	PF00017	SH2	SH2 domain
TRG_ER_diLys_1	PF00400	WD40	WD domain, G-beta repeat
LIG_SH3_2	PF07653	SH3_2	Variant SH3 domain
LIG_Actin_RPEL_3	PF02755	RPEL	RPEL repeat
LIG_EH_1	PF12763	efhand_3	Cytoskeletal-regulatory complex EF hand
TRG_ER_diArg_1	PF00400	WD40	WD domain, G-beta repeat
DEG_CRL4_CDT2_1	PF02747	PCNA_C	Proliferating cell nuclear antigen, C-terminal domain
DEG_CRL4_CDT2_1	PF00400	WD40	WD domain, G-beta repeat
DEG_CRL4_CDT2_2	PF02747	PCNA_C	Proliferating cell nuclear antigen, C-terminal domain
DEG_CRL4_CDT2_2	PF00400	WD40	WD domain, G-beta repeat
LIG_Pex14_1	PF04695	Pex14_N	Peroxisomal membrane anchor protein (Pex14p) conserved region
LIG_Pex14_2	PF04695	Pex14_N	Peroxisomal membrane anchor protein (Pex14p) conserved region
LIG_Pex3_1	PF04882	Peroxin-3	Peroxin-3
LIG_Integrin_isoDGR_2	PF08441	Integrin_alpha2	Integrin alpha
LIG_Integrin_isoDGR_2	PF00362	Integrin_beta	Integrin, beta chain
LIG_Integrin_isoDGR_2	PF01839	FG-GAP	FG-GAP repeat
LIG_SPRY_1	PF00622	SPRY	SPRY domain
LIG_PAM2_1	PF00658	PABP	Poly-adenylate binding protein, unique domain
CLV_Separin_Fungi	PF03568	Peptidase_C50	Peptidase family C50
CLV_Separin_Metazoa	PF03568	Peptidase_C50	Peptidase family C50
LIG_CaM_IQ_9	PF13499	EF_hand_7	EF-hand domain pair
CLV_C14_Caspase3-7	PF00656	Peptidase_C14	Caspase domain
LIG_HCF-1_HBM_1	PF13415	Kelch_3	Galactose oxidase, central domain
DOC_PIKK_1	PF02985	HEAT	HEAT repeat
LIG_eIF4E_1	PF01652	IF4E	Eukaryotic initiation factor 4E
LIG_eIF4E_2	PF01652	IF4E	Eukaryotic initiation factor 4E
MOD_LATS_1	PF00069	Pkinase	Protein kinase domain
MOD_LATS_1	PF00433	Pkinase_C	Protein kinase C terminal domain
MOD_NEK2_1	PF00069	Pkinase	Protein kinase domain
MOD_NEK2_2	PF00069	Pkinase	Protein kinase domain
LIG_EABR_CEP55_1	PF12180	EABR	TSG101 and ALIX binding domain of CEP55
LIG_PAM2_2	PF00658	PABP	Poly-adenylate binding protein, unique domain
LIG_MYND_2	PF01753	zf-MYND	MYND finger
LIG_MYND_3	PF01753	zf-MYND	MYND finger
DEG_APCC_TPR_1	SM00028	TPR	Tetratricopeptide repeats.
LIG_NBox_RRM_1	PF00076	RRM_1	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DEG_SCF_TIR1_1	SM00370	LRR	Leucine-rich repeats, outliers
DEG_SCF_COI1_1	SM00370	LRR	Leucine-rich repeats, outliers
DEG_Nend_UBRbox_4	PF02207	zf-UBR	Putative zinc finger in N-recognin (UBR box)
DEG_Nend_UBRbox_1	PF02207	zf-UBR	Putative zinc finger in N-recognin (UBR box)
DEG_Nend_UBRbox_2	PF02207	zf-UBR	Putative zinc finger in N-recognin (UBR box)
DEG_Nend_UBRbox_3	PF02207	zf-UBR	Putative zinc finger in N-recognin (UBR box)
LIG_CaMK_CASK_1	PF00069	Pkinase	Protein kinase domain
LIG_SH3_2	PF14604	SH3_9	Variant SH3 domain
DOC_CKS1_1	PF01111	CKS	Cyclin-dependent kinase regulatory subunit
LIG_SUFU_1	PF05076	SUFU	Suppressor of fused protein (SUFU)
LIG_SUFU_1	PF12470	SUFU_C	Suppressor of Fused Gli/Ci N terminal binding domain
DOC_PP1_SILK_1	PF00149	Metallophos	Calcineurin-like phosphoesterase
LIG_WD40_WDR5_WIN_1	IPR017986	IPR017986	WD40-repeat-containing domain
LIG_WD40_WDR5_WIN_2	IPR017986	IPR017986	WD40-repeat-containing domain
LIG_WD40_WDR5_WIN_3	IPR017986	IPR017986	WD40-repeat-containing domain
LIG_WD40_WDR5_VDV_1	IPR017986	IPR017986	WD40-repeat-containing domain
LIG_WD40_WDR5_VDV_2	IPR017986	IPR017986	WD40-repeat-containing domain
DOC_PP2B_LxvP_1	PF00149	Metallophos	Calcineurin-like phosphoesterase
DOC_PP2B_LxvP_1	PF13499	EF_hand_7	EF-hand domain pair
LIG_LIR_Gen_1	PF02991	Atg8	Autophagy protein Atg8 ubiquitin like
LIG_LIR_Apic_2	PF02991	Atg8	Autophagy protein Atg8 ubiquitin like
LIG_LIR_Nem_3	PF02991	Atg8	Autophagy protein Atg8 ubiquitin like
LIG_LIR_LC3C_4	PF02991	Atg8	Autophagy protein Atg8 ubiquitin like
LIG_EF_ALG2_ABM_1	SM00054	EFh	EF-hand, calcium binding motif
LIG_EF_ALG2_ABM_2	SM00054	EFh	EF-hand, calcium binding motif
DOC_PP1_MyPhoNE_1	PF00149	Metallophos	Calcineurin-like phosphoesterase
LIG_CNOT1_NIM_1	PF04054	Not1	CCR4-Not complex component, Not1
DOC_PP2A_KARD_1	PF01603	B56	Protein phosphatase 2A regulatory B subunit (B56 family)
LIG_Pex14_3	PF04695	Pex14_N	Peroxisomal membrane anchor protein (Pex14p) conserved region
LIG_Pex14_4	PF04695	Pex14_N	Peroxisomal membrane anchor protein (Pex14p) conserved region
LIG_RPA_C_Vert	PF08784	RPA_C	Replication protein A C terminal
LIG_RPA_C_Plants	PF08784	RPA_C	Replication protein A C terminal
LIG_RPA_C_Insects	PF08784	RPA_C	Replication protein A C terminal
LIG_RPA_C_Fungi	PF08784	RPA_C	Replication protein A C terminal
LIG_Mtr4_Trf4_1	PF00270	DEAD	DEAD/DEAH box helicase
LIG_Mtr4_Trf4_2	PF00270	DEAD	DEAD/DEAH box helicase
LIG_Mtr4_Air2_1	PF00270	DEAD	DEAD/DEAH box helicase
LIG_Nrd1CID_NIM_1	IPR006569	CID domain	The C-terminal domain (CTD) of the large subunit of RNA polymerase II is a platform for mRNA processing factors and links gene transcription to mRNA capping, splicing and polyadenylation. CTD recognition is dependent on the phosphorylation state of the CTD itself, which varies during the course of transcription but has also been linked to the isomerization state of the CTD's proline residues. Several RNA-processing factors recognise the CTD by means of a conserved CTD-interacting domain (CID). Factors with CID domains include the serine/arginine-rich-like factors SCAF4 and SCAF8, Nrd1 (which is implicated in polyadenylation-independent RNA 3'-end formation) and Pcf11. Pcf11 is a conserved and essential subunit of the yeast cleavage factor 1A, which is required for 3'-RNA processing and transcription termination [, ]. The CID domain is a right-handed superhelix of eight alpha-helices forming a compact domain. The CID fold closely resembles that of VHS domains and is related to armadillo-repeat proteins, except for the two amino-terminal helices. Amino acid residues in the hydrophobic core of the domain are highly conserved across CID domains [, ].
DEG_SPOP_SBC_1	PF00917	MATH	MATH domain
DEG_Kelch_Keap1_1	PF01344	Kelch_1	Kelch motif
DEG_Kelch_Keap1_2	PF01344	Kelch_1	Kelch motif
DEG_Kelch_actinfilin_1	PF01344	Kelch_1	Kelch motif
DEG_Kelch_KLHL3_1	PF01344	Kelch_1	Kelch motif
MOD_SUMO_rev_2	PF00179	UQ_con	Ubiquitin-conjugating enzyme
DOC_GSK3_Axin_1	PF00069	Pkinase	Protein kinase domain
DOC_USP7_UBL2_3	PF12436	USP7_ICP0_bdg	ICP0-binding domain of Ubiquitin-specific protease 7
LIG_DCNL_PONY_1	PF03556	Cullin_binding	Cullin binding
LIG_LRP6_Inhibitor_1	PF00058	Ldl_recept_b	Low-density lipoprotein receptor repeat class B
LIG_FZD_DVL_PDZ	PF00595	PDZ	PDZ domain (Also known as DHR or GLGF)
LIG_CaM_NSCaTE_8	PF13499	EF_hand_7	EF-hand domain pair
LIG_CaM_1-26_7	PF13499	EF_hand_7	EF-hand domain pair
LIG_CaM_1-17_6	PF13499	EF_hand_7	EF-hand domain pair
LIG_CaM_1-8-9-10_5	PF13499	EF_hand_7	EF-hand domain pair
LIG_CaM_1-8-14_4	PF13499	EF_hand_7	EF-hand domain pair
LIG_CaM_1-5-10-14_3	PF13499	EF_hand_7	EF-hand domain pair
LIG_CaM_1-8_REV_2	PF13499	EF_hand_7	EF-hand domain pair
LIG_CaM_1-14-15-16_REV_1	PF13499	EF_hand_7	EF-hand domain pair
LIG_GSK3_LRP6_1	PF00069	Pkinase	Protein kinase domain
LIG_KLC1_WD_1	SM00028	TPR	Tetratricopeptide repeats.
LIG_G3BP_FGDF_1	PF02136	NTF2	Nuclear transport factor 2 (NTF2) domain
LIG_CSL_BTD_1	PF09270	BTD	Beta-trefoil DNA-binding domain
DOC_MAPK_RevD_3	PF00069	Pkinase	Protein kinase domain
LIG_ANK_PxLPxL_1	PF00023	Ank	Ankyrin repeat
LIG_ANK_PxLPxL_1	SM00248	ANK	ankyrin repeats
LIG_14-3-3_CanoR_1	PF00244	14-3-3	14-3-3 protein
LIG_14-3-3_CterR_2	PF00244	14-3-3	14-3-3 protein
LIG_PALB2_WD40_1	PF16756	PALB2_WD40	Partner and localizer of BRCA2 WD40 domain
LIG_CAP-Gly_2	PF01302	CAP_GLY	CAP-Gly domain
LIG_APCC_Cbox_2	PF00515	TPR_1	Tetratricopeptide repeat
LIG_APCC_Cbox_1	PF00515	TPR_1	Tetratricopeptide repeat
CLV_PCSK_KEX2_1	PF00082	Peptidase_S8	Subtilase family
CLV_MEL_PAP_1	PF00089	Trypsin	Trypsin
LIG_SUMO_SIM_par_1	PF11976	Rad60-SLD	Ubiquitin-2 like Rad60 SUMO-like
LIG_SUMO_SIM_anti_2	PF11976	Rad60-SLD	Ubiquitin-2 like Rad60 SUMO-like
LIG_GBD_WASP_1	PF00786	PBD	P21-Rho-binding domain
LIG_OCRL_FandH_1	PF00620	RhoGAP	RhoGAP domain
LIG_UFM1_UFIM_1	PF03671	Ufm1	Ubiquitin fold modifier 1 protein
DOC_MAPK_JIP1_4	PF00069	Pkinase	Protein kinase domain
DOC_MAPK_NFAT4_5	PF00069	Pkinase	Protein kinase domain
LIG_CSK_EPIYA_1	PF00017	SH2	SH2 domain
DOC_PP2A_B56_1	IPR016024	Armadillo-type fold	This entry represents a structural domain with an armadillo (ARM)-like fold, consisting of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix, where the repeats that make up this structure are arranged about a common axis [ ]. These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. Domains and repeats with an ARM-like fold have been found in a number of proteins, including: ARM repeat domain, found in beta-catenins, importins, karyopherin and exportins. HEAT repeat domain, found in protein phosphatase 2a and initiation factor eIF4G. PHAT domain, found in the RNA-binding protein Smaug. Leucine-rich repeat variant, which contain an FeS cluster. Pumilo repeat domain, found in Pumilo protein. Regulatory subunit H of V-type ATPases. PBS lyase HEAT-like repeat. Mo25 protein. MIF4G domain-like, found in eukaryotic initiation factor eIF4G, translation initiation factor eIF-2b epsilon and nuclear cap-binding protein CBP80. The N-terminal domain of eukaryotic translation initiation factor 3 subunit 12. The C-terminal domain of leukotriene A4 hydrolase. The helical domain of phosphoinositide 3-kinase. The N-terminal fragment of adaptin alpha-C and beta subunits. The proximal leg segment and the linker domain of the clathrin heavy chain. The sequence similarity among these different repeats or domains is low, however they exhibit considerable structural similarity. Furthermore, the number of repeats present in the superhelical structure can vary between orthologues, indicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats [ ].
DEG_COP1_1	PF00400	WD40	WD domain, G-beta repeat
LIG_BH_BH3_1	PF00452	Bcl-2	Apoptosis regulator proteins, Bcl-2 family
MOD_CDK_SPxxK_3	PF00069	Pkinase	Protein kinase domain
MOD_CDK_SPK_2	PF00069	Pkinase	Protein kinase domain
DOC_MAPK_MEF2A_6	PF00069	Pkinase	Protein kinase domain
DOC_MAPK_DCC_7	PF00069	Pkinase	Protein kinase domain
DOC_MAPK_HePTP_8	PF00069	Pkinase	Protein kinase domain
LIG_APCC_ABBA_1	PF00400	WD40	WD domain, G-beta repeat
LIG_APCC_ABBAyCdc20_2	PF00400	WD40	WD domain, G-beta repeat
DOC_MAPK_GRA24_9	PF00069	Pkinase	Protein kinase domain
LIG_IRFs_LxIS_1	PF10401	IRF-3	Interferon-regulatory factor 3
LIG_14-3-3_ChREBP_3	PF00244	14-3-3	14-3-3 protein
LIG_IBAR_NPY_1	PF08397	IMD	IRSp53/MIM homology domain
LIG_UBA3_1	PF00899	ThiF	ThiF family
LIG_GBD_Chelix_1	PF00786	PBD	P21-Rho-binding domain
LIG_Vh1_VBS_1	PF01044	Vinculin	Vinculin family
MOD_Plk_4	PF00069	Pkinase	Protein kinase domain
MOD_Plk_1	PF00069	Pkinase	Protein kinase domain
DOC_CYCLIN_RxL_1	PF00134	Cyclin_N	Cyclin, N-terminal domain
MOD_Plk_2-3	PF00069	Pkinase	Protein kinase domain
LIG_PROFILIN_1	PF00235	Profilin	Profilin
DEG_Nend_Nbox_1	PF02207	zf-UBR	Putative zinc finger in N-recognin (UBR box)
TRG_ER_FFAT_2	PF00635	Motile_Sperm	MSP (Major sperm protein) domain
LIG_REV1ctd_RIR_1	PF16727	REV1_C	DNA repair protein REV1 C-terminal domain
LIG_PDZ_Wminus1_1	PF00595	PDZ	PDZ domain (Also known as DHR or GLGF)
LIG_FXI_DFP_1	PF00024	PAN_1	PAN domain
LIG_SH2_CRK	PF00017	SH2	SH2 domain
LIG_deltaCOP1_diTrp_1	PF00928	Adap_comp_sub	Adaptor complexes medium subunit family
LIG_MLH1_MIPbox_1	PF16413	Mlh1_C	DNA mismatch repair protein Mlh1 C-terminus
MOD_DYRK1A_RPxSP_1	PF00069	Pkinase	Protein kinase domain
TRG_Pf-PMV_PEXEL_1	PF00026	Asp	Eukaryotic aspartyl protease
LIG_SH2_STAP1	PF00017	SH2	SH2 domain
LIG_ARL_BART_1	PF11527	ARL2_Bind_BART	The ARF-like 2 binding protein BART
LIG_PCNA_APIM_2	PF02747	PCNA_C	Proliferating cell nuclear antigen, C-terminal domain
LIG_SH2_NCK_1	PF00017	SH2	SH2 domain
DOC_PP4_MxPP_1	PF00568	WH1	WH1 domain
DOC_PP4_FxxP_1	PF00568	WH1	WH1 domain
LIG_PCNA_yPIPBox_3	PF02747	PCNA_C	Proliferating cell nuclear antigen, C-terminal domain
LIG_PCNA_TLS_4	PF02747	PCNA_C	Proliferating cell nuclear antigen, C-terminal domain
LIG_KLC1_Yacidic_2	PF13176	TPR_7	Tetratricopeptide repeat
DOC_CDC14_PxL_1	PF14671	DSPn	Dual specificity protein phosphatase, N-terminal half
DOC_CYCLIN_yClb1_LxF_4	PF00134	Cyclin_N	Cyclin, N-terminal domain
DOC_CYCLIN_yCln2_LP_2	PF00134	Cyclin_N	Cyclin, N-terminal domain
LIG_LSD1_SNAG_1	PF01593	Amino_oxidase	Flavin containing amine oxidoreductase
DOC_CYCLIN_yClb3_PxF_3	PF00134	Cyclin_N	Cyclin, N-terminal domain
LIG_NRP_CendR_1	PF00754	F5_F8_type_C	F5/8 type C domain
LIG_DLG_GKlike_1	PF00625	Guanylate_kin	Guanylate kinase
LIG_SH3_CIN85_PxpxPR_1	PF14604	SH3_9	Variant SH3 domain
DOC_CYCLIN_yClb5_NLxxxL_5	PF00134	Cyclin_N	Cyclin, N-terminal domain
LIG_WRC_WIRS_1	PF07815	Abi_HHR	Abl-interactor HHR
LIG_WRC_WIRS_1	PF05994	FragX_IP	Cytoplasmic Fragile-X interacting family
LIG_LYPXL_yS_3	PF13949	ALIX_LYPXL_bnd	ALIX V-shaped domain binding to HIV
LIG_LYPXL_SIV_4	PF13949	ALIX_LYPXL_bnd	ALIX V-shaped domain binding to HIV
DOC_CYCLIN_D_Helix_1	IPR039361	Cyclin	Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles, and regulate cyclin dependent kinases (CDKs)
LIG_Integrin_RGD_TGFB_3	PF00362	Integrin_beta	Integrin, beta chain
LIG_Integrin_RGD_TGFB_3	PF01839	FG-GAP	FG-GAP repeat
DEG_SCF_FBXO31_1	PF12014	Cyclin_D1_bind	Cyclin D1 binding domain
LIG_ActinCP_CPI_1	PF01267	F-actin_cap_A	F-actin capping protein alpha subunit
LIG_ActinCP_CPI_1	PF01115	F_actin_cap_B	F-actin capping protein, beta subunit
LIG_ActinCP_TwfCPI_2	PF01267	F-actin_cap_A	F-actin capping protein alpha subunit
LIG_ActinCP_TwfCPI_2	PF01115	F_actin_cap_B	F-actin capping protein, beta subunit
LIG_Integrin_RGDW_4	PF01839	FG-GAP	FG-GAP repeat
LIG_Integrin_RGDW_4	PF00362	Integrin_beta	Integrin, beta chain
LIG_RuBisCO_WRxxL_1	PF00101	RuBisCO_small	Ribulose bisphosphate carboxylase, small chain
LIG_Integrin_KxxGD_FGGC_5	PF01839	FG-GAP	FG-GAP repeat
LIG_Integrin_KxxGD_FGGC_5	PF00362	Integrin_beta	Integrin, beta chain
TRG_DiLeu_BaEn_1	PF01217	Clat_adaptor_s	Clathrin adaptor complex small chain
TRG_DiLeu_BaLyEn_6	PF01217	Clat_adaptor_s	Clathrin adaptor complex small chain
TRG_DiLeu_BaEn_2	PF01217	Clat_adaptor_s	Clathrin adaptor complex small chain
TRG_DiLeu_BaEn_3	PF01217	Clat_adaptor_s	Clathrin adaptor complex small chain
TRG_DiLeu_BaEn_4	PF01217	Clat_adaptor_s	Clathrin adaptor complex small chain
TRG_DiLeu_LyEn_5	PF01217	Clat_adaptor_s	Clathrin adaptor complex small chain
MOD_CDC14_SPxK_1	PF00782	DSPc	Dual specificity phosphatase, catalytic domain
DOC_MIT_MIM_1	PF04212	MIT	MIT (microtubule interacting and transport) domain
LIG_TRAF6_MATH_1	IPR037309	TNF receptor-associated factor 6, MATH domain	TNF receptor-associated factor 6 (TRAF6) regulates a diverse array of processes, including adaptive immunity, innate immunity, bone metabolism and tissue development
LIG_TRAF4_MATH_1	IPR002083	MATH/TRAF domain	Although apparently functionally unrelated, intracellular TRAFs and extracellular meprins share a conserved region of about 180 residues, the meprin and TRAF homology (MATH) domain
LIG_Menin_MBM1_1	IPR007747	Menin	The tumour suppressor gene MEN1 is mutated in patients with a dominantly inherited tumour syndrome, multiple endocrine neoplasia type 1 (MEN1)
MOD_NEK2_1	IPR000719	Protein kinase domain	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases
LIG_LEDGF_IBM_1	IPR021567	Lens epithelium-derived growth factor, integrase-binding domain	Lens epithelium-derived growth factor (LEDGF), also known as transcriptional co-activator p75, is a chromatin-associated protein that protects cells from stress-induced apoptosis
LIG_Arc_Nlobe_1	IPR040814	Activity-regulated cytoskeleton-associated protein, C-terminal domain	This entry represents the C-terminal capsid-like domain of the Activity-regulated cytoskeleton-associated protein (Arc)
DEG_Kelch_KLHL12_1	PF01344	Kelch_1	Kelch motif
LIG_CaMK_CASK_1	IPR000719	Protein kinase domain	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases
LIG_VCP_VBM_3	IPR003338	CDC48, N-terminal subdomain	The CDC48 N-terminal domain is a protein domain found in AAA ATPases including cell division protein 48 (CDC48), VCP-like ATPase (VAT) and N-ethylmaleimide sensitive fusion protein
LIG_VCP_VIM_2	IPR003338	CDC48, N-terminal subdomain	The CDC48 N-terminal domain is a protein domain found in AAA ATPases including cell division protein 48 (CDC48), VCP-like ATPase (VAT) and N-ethylmaleimide sensitive fusion protein
LIG_VCP_SHPBox_1	IPR003338	CDC48, N-terminal subdomain	The CDC48 N-terminal domain is a protein domain found in AAA ATPases including cell division protein 48 (CDC48), VCP-like ATPase (VAT) and N-ethylmaleimide sensitive fusion protein
DEG_Kelch_KLHL12_1	IPR006652	Kelch repeat type 1	Kelch is a 50-residue motif, named after the Drosophila mutant in which it was first identified
DEG_APCC_DBOX_1	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	This superfamily represents a WD40/YVTN repeat-like domain
DEG_CRBN_cyclicCter_1	IPR034750	CULT domain	The cereblon protein, originally identified in a screen for mutations causing mild mental retardation, is a major target of thalidomide and its derivatives, and is responsible for the teratogenic effects of the drug
MOD_LOK_YxT_1	IPR000719	Protein kinase domain	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases
LIG_ARS2_EDGEI_1	IPR007042	SERRATE/Ars2, C-terminal	This domain can be found in the C terminus of the SERRATE (SE) from plants and its homologue, Ars2, from animals
LIG_IRFs_LxIS_1	IPR019471	Interferon regulatory factor-3	This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein
LIG_IRF7_LxLS_2	IPR019471	Interferon regulatory factor-3	This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein
LIG_MTR4_AIM_1	IPR025696	rRNA-processing arch domain	The essential RNA helicase Mtr4 is an exosome-activating cofactor
LIG_FERM_MyoX_1	IPR041797	Myosin X, FERM domain C-lobe	MyoX, a MyTH-FERM myosin, is a molecular motor that has crucial functions in the transport and/or tethering of integrins in the actin-based extensions known as filopodia, microtubule binding, and in netrin-mediated axon guidance
LIG_Trf4_IWRxY_1	IPR002058	PAP/25A-associated	This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity
DEG_Cend_TRIM7_1	IPR003877	SPRY domain	The SPRY domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions
DEG_Cend_FEM1B_2	IPR002110	Ankyrin repeat	The ankyrin repeat is one of the most common protein-protein interaction motifs in nature
LIG_MSH2_SHIPbox_1	IPR007696	DNA mismatch repair protein MutS, core	Mismatch repair contributes to the overall fidelity of DNA replication and is essential for combating the adverse effects of damage to the genome
LIG_TRAF2like_MATH_loPxQ_2	IPR037304	TRAF3, MATH domain	Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated protein (MAP) kinase activation and non-canonical nuclear factor-kB signalling
LIG_TRAF2like_MATH_loPxQ_2	IPR037305	TNF receptor-associated factor 2, MATH domain	TNF receptor-associated factor 2 (TRAF2) regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis
LIG_TRAF2like_MATH_loPxQ_2	IPR037306	TNF receptor-associated factor 1, MATH domain	TNF receptor-associated factor 1 (TRAF1) plays a role in the regulation of cell survival and apoptosis
LIG_TRAF3_MATH_PxP_3	IPR037304	TRAF3, MATH domain	Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated protein (MAP) kinase activation and non-canonical nuclear factor-kB signalling
LIG_TRAF2like_MATH_shPxQ_1	IPR037304	TRAF3, MATH domain	Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated protein (MAP) kinase activation and non-canonical nuclear factor-kB signalling
LIG_TRAF2like_MATH_shPxQ_1	IPR037305	TNF receptor-associated factor 2, MATH domain	TNF receptor-associated factor 2 (TRAF2) regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis
LIG_TRAF2like_MATH_shPxQ_1	IPR037306	TNF receptor-associated factor 1, MATH domain	TNF receptor-associated factor 1 (TRAF1) plays a role in the regulation of cell survival and apoptosis
MOD_AAK1BIKe_LxxQxTG_1	IPR000719	Protein kinase domain	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases
DEG_Cend_DCAF12_1	IPR001680	WD40 repeat	WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide
DOC_PUB_PIM_1	IPR018997	PUB domain	The PUB (also known as PUG) domain is found in peptide N-glycanase where it functions as a AAA ATPase binding domain
LIG_RBL1_LxSxE_2	PF01857	RB_B	Retinoblastoma-associated protein B domain
LIG_RBL1_LxSxE_2	IPR002719	Retinoblastoma-associated protein, B-box	This entry includes retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also known as RB2 or p130)
DOC_PP2B_PxIxIT_1	IPR004843	Calcineurin-like phosphoesterase domain, ApaH type	This domain is found in a diverse range of phosphoesterases, including bis(5'-nucleosyl)-tetraphosphatase (apaH), nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases, as well as nucleases such as bacterial SbcD or archaeal/yeast Mre11
LIG_SH3_PxRPPK_7	IPR001452	SH3 domain	SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
LIG_SH3_PxxxRxxKP_6	IPR001452	SH3 domain	SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
LIG_SH3_PxxPPRxxK_8	IPR001452	SH3 domain	SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
DOC_CYCLIN_RevRxL_6	IPR006671	Cyclin, N-terminal	Cyclins contain two domains of similar all-alpha fold, of which this entry is associated with the N-terminal domain
LIG_SH3_PxxDY_5	IPR001452	SH3 domain	SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
LIG_CtBP_RRT_2	IPR006140	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain	A number of NAD-dependent 2-hydroxyacid dehydrogenases which seem to be specific for the D-isomer of their substrate have been shown to be functionally and structurally related
LIG_RB_pABgroove_1	IPR002719	Retinoblastoma-associated protein, B-box	This entry includes retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also known as RB2 or p130)
LIG_RB_pABgroove_1	IPR002720	Retinoblastoma-associated protein A-box	Retinoblastoma-like and retinoblastoma-associated proteins may have a function in cell cycle regulation
DEG_Cend_KLHDC2_1	IPR015915	Kelch-type beta propeller	This entry represents the 6-bladed Kelch beta-propeller, which consists of six 4-stranded beta-sheet motifs or six Kelch repeats
LIG_Integrin_collagen_1	IPR002035	von Willebrand factor, type A	The von Willebrand factor is a large multimeric glycoprotein found in blood plasma
DOC_RSK_DDVF_1	IPR000719	Protein kinase domain	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases
LIG_SH2_SFK_2	IPR000980	SH2 domain	The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps
LIG_SH2_SFK_CTail_3	IPR000980	SH2 domain	The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps
DOC_TBK1_STING_1	IPR041309	TANK-binding kinase 1, coiled-coil domain 1	This is a coiled-coil domain found in TANK-binding kinase 1 (TBK1), it comprises one of two coiled-coil domains found in the scaffold dimerization region
DOC_TBK1_STING_1	IPR000719	Protein kinase domain	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases
LIG_Integrin_RGDSP_6	PF01839	FG-GAP	FG-GAP repeat
LIG_Integrin_RGDSP_6	PF00362	Integrin_beta	Integrin, beta chain
LIG_RB_LxCxE_1	IPR002719	Retinoblastoma-associated protein, B-box	This entry includes retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also known as RB2 or p130)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement

feedback@elm.eu.org