The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Functional site class:
Immunoreceptor tyrosine-based motif
Functional site description:
In the cytoplasmatic region of immunoreceptors there are motifs that are critical for the activation and termination of signal transduction pathways.
ELMs with same func. site: LIG_TYR_ITAM  LIG_TYR_ITIM  LIG_TYR_ITSM 
ELM Description:
ITAM (immunoreceptor tyrosine-based activatory motif). ITAM consists of partially conserved short sequence of amino acid found in the cytoplasmatic tail of antigen and Fc receptors.
Pattern: [DEN]..(Y)..[LI].{6,12}(Y)..[LI]
Pattern Probability: 0.0000024
Present in taxon: Vertebrata
Interaction Domain:
SH2 (PF00017) SH2 domain (Stochiometry: 2 : 1)
PDB Structure: 1A81
o See 7 Instances for LIG_TYR_ITAM
o Abstract
Antigen recognition and communication among cells (T, B and natural killer cells) of the immune system are regulated at the level of cell-surface antigen and transmembrane receptors. The extracellular regions of these receptors provide the immune specificity, whereas the intracellular region interacts with cytoplasmatic signaling molecules that are critical for the activation and termination of signal transduction pathways. The initial signaling events following the engagement of antigen receptors are regulated by the phosphorylation of characteristic signaling motifs that coordinate the activity of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPases), and thus regulate the activation or inhibition of the intracellular response. Some receptors like CD154, CD28, CD3 transmit mainly positive co-stimulatory signals, whereas others, such as CTLA-4 killer inhibitory receptors (KIRs) or leukocyte immunoglobulin-like receptors (LIRs), function principally as inhibitory receptors. In addition, a group of dual-function receptors, such as the CD150 subfamily within the CD2 family, can either act as positive or negative regulators.
o 4 selected references:

o 2 GO-Terms:

o 7 Instances for LIG_TYR_ITAM
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P20963 CD247
69 86 QNQLYNELNLGRREEYDVLD TP 3 Homo sapiens (Human)
P07766 CD3E
185 202 PNPDYEPIRKGQRDLYSGLN TP 7 Homo sapiens (Human)
P30273 FCER1G
62 79 SDGVYTGLSTRNQETYETLK TP 5 Homo sapiens (Human)
P15530 Cd79b
192 209 EDHTYEGLNIDQTATYEDIV TP 6 Mus musculus (House mouse)
P40259 CD79B
193 210 EDHTYEGLDIDQTATYEDIV TP 4 Homo sapiens (Human)
P04234 CD3D
146 163 NDQVYQPLRDRDDAQYSHLG TP 2 Homo sapiens (Human)
P11912 CD79A
185 202 DENLYEGLNLDDCSMYEDIS TP 1 Homo sapiens (Human)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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