| Accession: | |
|---|---|
| Functional site class: | CAAX Box |
| Functional site description: | Prenyl groups are attached to a Cys residue 4 residues preceding the C-terminus of certain proteins directed to the plasma membrane |
| ELM Description: | Generic CAAX box prenylation motif. Recognised by Farnesyltransferase and Geranylgeranyltransferase I for transfer of lipophilic units to one or more C-terminal Cys residues. |
| Pattern: | (C)[^DENQ][LIVMF].$ |
| Pattern Probability: | 0.0000024 |
| Present in taxon: | Eukaryota |
| Interaction Domain: |
PPTA (PF01239)
Protein prenyltransferase alpha subunit repeat
(Stochiometry: 1 : 1)
|
 Abstract |
Protein prenyltransferases recognise an exposed Cys residue preceding the C-terminus of certain protein substrates. The enzymes covalently attach a prenyl group (farnesyl or geranyl-geranyl) to the Cys residue with the consequence that the (soluble) protein is attached to the membrane. Examples of CAAX box proteins include the Ras-like proteins and the G-protein gamma and (some alpha) subunits. Some effectors of bacterial pathogens also have CAAX boxes which are modified, directing the effector proteins to the membrance. |
8 GO-Terms:
17 Instances for MOD_CAAXbox
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement