The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Functional site class:
Functional site description:
Prenyl groups are attached to a Cys residue 4 residues preceding the C-terminus of certain proteins directed to the plasma membrane
ELM Description:
Generic CAAX box prenylation motif
Pattern: (C)[^DENQ][LIVM].$
Pattern Probability: 0.0000022
Present in taxon: Eukaryota
Interaction Domain:
PPTA (PF01239) Protein prenyltransferase alpha subunit repeat (Stochiometry: 1 : 1)
PDB Structure: 1TNZ
o See 2 Instances for MOD_CAAXbox
o Abstract
Protein prenyltransferases recognise an exposed Cys residue preceding the C-terminus of certain protein substrates. The enzymes covalently attach a prenyl group (farnesyl or geranyl-gernayl) to the Cys residue with the consequence that the (souble) protein is attached to the membrane. Examples of CAAX box proteins include the Ras-like proteins and the G-protein gamma and (some alpha) subunits.
o 8 GO-Terms:

o 2 Instances for MOD_CAAXbox
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
Q8CFN2 Cdc42
188 191 AILAALEPPEPKKSRRCVLL TP 1 Rattus norvegicus (Norway rat)
P60953 CDC42
188 191 AILAALEPPEPKKSRRCVLL TP 2 Homo sapiens (Human)
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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