The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Accession:
Functional site class:
CAAX Box
Functional site description:
Prenyl groups are attached to a Cys residue 4 residues preceding the C-terminus of certain proteins directed to the plasma membrane
ELM Description:
Generic CAAX box prenylation motif. Recognised by Farnesyltransferase and Geranylgeranyltransferase I for transfer of lipophilic units to one or more C-terminal Cys residues.
Pattern: (C)[^DENQ][LIVMF].$
Pattern Probability: 0.0000024
Present in taxon: Eukaryota
Interaction Domain:
PPTA (PF01239) Protein prenyltransferase alpha subunit repeat (Stochiometry: 1 : 1)
PDB Structure: 1TNZ
o See 15 Instances for MOD_CAAXbox
o Abstract
Protein prenyltransferases recognise an exposed Cys residue preceding the C-terminus of certain protein substrates. The enzymes covalently attach a prenyl group (farnesyl or geranyl-geranyl) to the Cys residue with the consequence that the (soluble) protein is attached to the membrane. Examples of CAAX box proteins include the Ras-like proteins and the G-protein gamma and (some alpha) subunits. Some effectors of bacterial pathogens also have CAAX boxes which are modified, directing the effector proteins to the membrance.
o 8 GO-Terms:

o 15 Instances for MOD_CAAXbox
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
Q56061 sifA
SIFA_SALTY
333 336 QLTTLHVRSEQQSGCLCCFL TP 5 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Q5ZSH6 lpg2541
Q5ZSH6_LEGPH
274 277 KQRKDTNNYKDTKKHRCTIM TP 3 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Q5ZSZ1 lpg2375
Q5ZSZ1_LEGPH
154 157 LHGEPEMTYKPKFTEQCSIL TP 3 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Q5WTP6 lpl2477
Q5WTP6_LEGPL
196 199 FYNSDSDSDTSDPDPKCTIM TP 3 Legionella pneumophila str. Lens
Q5ZYV7 lpg0254
Q5ZYV7_LEGPH
186 189 QEYSRLRWKPPEKESVCVLM TP 2 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Q5ZTL7 legAU13
Q5ZTL7_LEGPH
169 172 RALIRGMQEEKIAQSKCLVC TP 5 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
P01115 H-RAS
RASH_MSVHA
238 241 KLNPPDESGPGCMSCKCVLS TP 2 Harvey murine sarcoma virus
P34165 MFA1
MFA1_YEAST
33 36 EKKDNYIIKGVFWDPACVIA TP 1 Saccharomyces cerevisiae S288c
P01116-2 KRAS
RASK_HUMAN
185 188 KMSKDGKKKKKKSKTKCVIM TP 3 Homo sapiens (Human)
P01116 KRAS
RASK_HUMAN
186 189 KISKEEKTPGCVKIKKCIIM TP 1 Homo sapiens (Human)
P01111 NRAS
RASN_HUMAN
186 189 KLNSSDDGTQGCMGLPCVVM TP 2 Homo sapiens (Human)
P01112 HRAS
RASH_HUMAN
186 189 KLNPPDESGPGCMSCKCVLS TP 4 Homo sapiens (Human)
P20700 LMNB1
LMNB1_HUMAN
583 586 EELFHQQGTPRASNRSCAIM TP 3 Homo sapiens (Human)
Q8CFN2 Cdc42
CDC42_RAT
188 191 AILAALEPPEPKKSRRCVLL TP 1 Rattus norvegicus (Norway rat)
P60953 CDC42
CDC42_HUMAN
188 191 AILAALEPPEPKKSRRCVLL TP 2 Homo sapiens (Human)
1 
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement