The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Accession:
Functional site class:
Casein kinase 1 (CK1) Phosphorylation site
Functional site description:
Casein kinase 1 (CK1) comprises a family of serine/threonine kinases that are ubiquitous in eukaryotic system. It regulates diverse cellular processes including circadian rhythms (Shanware,2011), Wnt signaling pathway (Davidson,2005), hedgehog signaling and cell cycle (Price,2006, Knippschild,2005), membrane trafficking, cytoskeleton maintenance (Schittek,2014), DNA replication, DNA damage response, RNA metabolism, and parasitic infections (Rachidi,2014).
ELM Description:
CK1 phosphorylation site
Pattern: S..([ST])...
Pattern Probability: 0.0170407
Present in taxon: Eukaryota
Interaction Domain:
Pkinase (PF00069) Protein kinase domain (Stochiometry: 1 : 1)
o See 27 Instances for MOD_CK1_1
o Abstract
Casein kinase 1 (CK1) phosphorylates a wide variety of substrates. There are seven CK1 isoforms in vertebrates that are encoded by distinct genes (α, β, δ, ε, γ1, γ2, γ3) and that are post-transcriptionally processed to yield a number of splice variants (Burzio,2002, Schittek,2014). The existence of multiple isoforms in vertebrate cells makes understanding of their regulation complex and difficult. The enzyme is expressed ubiquitously throughout mammalian tissue and cell lines although different isoforms show subcellular localization within the cytoplasm, nuclei and associated with membranes and the cytoskeleton.

CK1 generally phosphorylate Ser/Thr residues with a primed phosphorylation site or acidic residues at the -3 position (Flotow,1991). Mutations in either CK1 or in CK1 phosphorylation sites are associated with many human malignancies such as altered circadian rhythm (Shanware,2011), neurodegenerative diseases and various types of cancers (Schittek,2014, Cozza,2016).
o 9 selected references:

o 3 GO-Terms:

o 27 Instances for MOD_CK1_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P30304 CDC25A
MPIP1_HUMAN
79 85 RMGSSESTDSGFCLDSPGPL TP 5 Homo sapiens (Human)
1 
P70444 Bid
BID_MOUSE
61 67 ELQTDGSQASRSFNQGRIEP TP 5 Mus musculus (House mouse)
2 
Q13158 FADD
FADD_HUMAN
197 203 RSGAMSPMSWNSDASTSEAS TP 7 Homo sapiens (Human)
1 
P09803 Cdh1
CADH1_MOUSE
849 855 EAASLSSLNSSESDQDQDYD TP 5 Mus musculus (House mouse)
1 
P51141 Dvl1
DVL1_MOUSE
139 145 NETGTESMVSHRRERARRRN TP 6 Mus musculus (House mouse)
1 
Q6IE81-3 JADE1
JADE1_HUMAN
18 24 DSDDNGSLSTTWSQNSRSQH TP 4 Homo sapiens (Human)
1 
O15151 MDM4
MDM4_HUMAN
291 297 EDSKSLSDDTDVEVTSEDEW TP 6 Homo sapiens (Human)
1 
P25054 APC
APC_HUMAN
1507 1513 SCSSSLSALSLDEPFIQKDV TP 3 Homo sapiens (Human)
3 
Q12778 FOXO1
FOXO1_HUMAN
322 328 RTSSNASTISGRLSPIMTEQ TP 4 Homo sapiens (Human)
2 
O15055 PER2
PER2_HUMAN
665 671 KAESVASLTSQCSYSSTIVH TP 6 Homo sapiens (Human)
2 
Q8TD43 TRPM4
TRPM4_HUMAN
839 845 LSGGGGSLASGGPGPGHASL TP 4 Homo sapiens (Human)
1 
Q9NRF8 CTPS2
PYRG2_HUMAN
571 577 DRYSDASDDSFSEPRIAELE TP 4 Homo sapiens (Human)
Q16665 HIF1A
HIF1A_HUMAN
244 250 DSKTFLSRHSLDMKFSYCDE TP 3 Homo sapiens (Human)
1 
O94916 NFAT5
NFAT5_HUMAN
155 161 EDLLDNSRMSCQDEGCGLES TP 4 Homo sapiens (Human)
1 
Q96524 CRY2
CRY2_ARATH
584 590 FVSQSCSLASEGKNLEGIQD TP 2 Arabidopsis thaliana (Thale cress)
2 
Q9BZL6 PRKD2
KPCD2_HUMAN
244 250 SSSSSASSYTGRPIELDKML TP 5 Homo sapiens (Human)
2 
P13864 Dnmt1
DNMT1_MOUSE
150 156 TLSVETSPSSVATRRTTRQT TP 4 Mus musculus (House mouse)
2 
Q5S006 Lrrk2
LRRK2_MOUSE
958 964 ILSSDESLRSSRLPSHMRQS TP 5 Mus musculus (House mouse)
1 
Q92858 ATOH1
ATOH1_HUMAN
334 340 SKTSPRSHRSDGEFSPHSHY TP 5 Homo sapiens (Human)
1 
Q9Y6Q9 NCOA3
NCOA3_HUMAN
598 604 HLSDKESKESSVEGAENQRG TP 3 Homo sapiens (Human)
1 
Q00987 MDM2
MDM2_HUMAN
118 124 QQESSDSGTSVSENRCHLEG TP 5 Homo sapiens (Human)
1 
O43312 MTSS1
MTSS1_HUMAN
319 325 RLSSVSSHDSGFISQDAFQS TP 4 Homo sapiens (Human)
1 
Q99814 EPAS1
EPAS1_HUMAN
383 389 SGKGAVSEKSNFLFTKLKEE TP 3 Homo sapiens (Human)
1 
Q13114 TRAF3
TRAF3_HUMAN
349 355 NWEEADSMKSSVESLQNRVT TP 5 Homo sapiens (Human)
1 
Q14457 BECN1
BECN1_HUMAN
409 415 IEDTGGSGGSYSIKTQFNSE TP 5 Homo sapiens (Human)
1 
P46937-2 YAP1
YAP1_HUMAN
381 387 YHSRDESTDSGLSMSSYSVP TP 7 Homo sapiens (Human)
2 
P04637 TP53
P53_HUMAN
15 21 SVEPPLSQETFSDLWKLLPE TP 5 Homo sapiens (Human)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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