The Eukaryote Linear Motif resource for Functional Sites in Proteins
MOD_GSK3_1 53
 
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Functional site class: GSK3 phosphorylation site
Functional site description: Site recognised by GSK3 for Ser/Thr Phosphorylation
ELMs: MOD_GSK3_1
Description: The GSK3 phosphorylation recognition site is based primarily on vertebrate data. GSK3-family kinases are widespread in Eukaryota but in most cases the specificity has not been confirmed.
Pattern: ...([ST])...[ST] (Probability: 0.0267866)
Present in taxons: Eukaryota
Interaction Domain:

Pkinase (PF00069)
Protein kinase domain
(Stochiometry: 1 : 1)

o See 17 Instances for MOD_GSK3_1


o Abstract

GSK3 comprises two highly related proteins (GSK3-alpha and GSK3-beta) that phosphorylate a wide variety of target proteins. This kinase is expressed consitutively active in resting cells, and phosphorylation of several substrates is inhibitory suggesting this protein kinase may repress target protein function by phosphorylation. Major targets include Glycogen synthase, ATP citrate lysate, c-Jun, c-Myc, L-Myc and tau protein suggesting roles in the control of several different biochemical pathways

o 4 GO-Terms:

o 17 Instances for MOD_GSK3_1
(click table headers for sorting)
SequenceStartEndSubsequence
Instance LogicPDB Organism
CCNE1_HUMAN 392 399 ASPLPSGLLTPPQSGKKQSS true positive --- Homo sapiens (Human)
P53_HUMAN 30 37 KLLPENNVLSPLPSQAMDDL true positive --- Homo sapiens (Human)
ATX3_HUMAN 253 260 ADLRRAIQLSMQGSSRNISQ true positive --- Homo sapiens (Human)
JUN_HUMAN 236 243 QTVPEMPGETPPLSPIDMES true positive --- Homo sapiens (Human)
MYC_HUMAN 55 62 IWKKFELLPTPPLSPSRRSG true positive --- Homo sapiens (Human)
SNAI1_HUMAN 93 100 ELTSLSDEDSGKGSQPPSPP true positive --- Homo sapiens (Human)
NFAC1_HUMAN 238 245 GSPRHSPSTSPRASVTEESW true positive --- Homo sapiens (Human)
NFAC1_HUMAN 287 294 HSPTPSPHGSPRVSVTDDSW true positive --- Homo sapiens (Human)
SMAD1_HUMAN 207 214 STYPHSPTSSDPGSPFQMPA true positive --- Homo sapiens (Human)
SMAD1_HUMAN 199 206 PNSPGSSSSTYPHSPTSSDP true positive --- Homo sapiens (Human)
SMAD3_HUMAN 201 208 QMNHSMDAGSPNLSPNPMSP true positive --- Homo sapiens (Human)
MK67I_HUMAN 227 234 LDTPEKTVDSQGPTPVCTPT true positive --- Homo sapiens (Human)
MK67I_HUMAN 231 238 EKTVDSQGPTPVCTPTFLER true positive --- Homo sapiens (Human)
FGD3_HUMAN 77 84 IPNRDSGIDSPSSSVAGENF true positive --- Homo sapiens (Human)
FGD3_HUMAN 73 80 GSLKIPNRDSGIDSPSSSVA true positive --- Homo sapiens (Human)
HSF1_HUMAN 300 307 LVRVKEEPPSPPQSPRVEEA true positive --- Homo sapiens (Human)
CCNE1_HUMAN 388 395 EQNRASPLPSGLLTPPQSGK true positive --- Homo sapiens (Human)

Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)

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