The Eukaryote Linear Motif resource for Functional Sites in Proteins
Functional site class:
GSK3 phosphorylation site
Functional site description:
Site recognised by GSK3 for Ser/Thr phosphorylation.
ELM with this model: MOD_GSK3_1 
Description:
The GSK3 phosphorylation recognition site is based primarily on vertebrate data. GSK3-family kinases are widespread in Eukaryota but in most cases the specificity has not been confirmed.
Pattern: ...([ST])...[ST]
Pattern Probability: 0.0267866
Present in taxon: Eukaryota
Interaction Domain:
Pkinase (PF00069) Protein kinase domain (Stochiometry: 1 : 1)
o See 22 Instances for MOD_GSK3_1
o Abstract
GSK3 comprises two highly related proteins (GSK3-alpha and GSK3-beta) that phosphorylate a wide variety of target proteins. This kinase is expressed consitutively active in resting cells, and phosphorylation of several substrates is inhibitory, suggesting this protein kinase may repress target protein function by phosphorylation. Major targets include Glycogen synthase, ATP citrate lysate, c-Jun, c-Myc, L-Myc and tau protein suggesting roles in the control of several different biochemical pathways.
o 4 GO-Terms:

o 22 Instances for MOD_GSK3_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
CCNE1_HUMAN CCNE1 392 399 ASPLPSGLLTPPQSGKKQSS TP 1 Homo sapiens (Human)
2 
P53_HUMAN TP53 30 37 KLLPENNVLSPLPSQAMDDL TP 2 Homo sapiens (Human)
1 
1 
ATX3_HUMAN ATXN3 253 260 ADLRRAIQLSMQGSSRNISQ TP 2 Homo sapiens (Human)
1 
1 
JUN_HUMAN JUN 236 243 QTVPEMPGETPPLSPIDMES TP 1 Homo sapiens (Human)
2 
SNAI1_HUMAN SNAI1 93 100 ELTSLSDEDSGKGSQPPSPP TP 3 Homo sapiens (Human)
1 
NFAC1_HUMAN NFATC1 238 245 GSPRHSPSTSPRASVTEESW TP 2 Homo sapiens (Human)
1 
NFAC1_HUMAN NFATC1 287 294 HSPTPSPHGSPRVSVTDDSW TP 2 Homo sapiens (Human)
1 
SMAD1_HUMAN SMAD1 207 214 STYPHSPTSSDPGSPFQMPA TP 4 Homo sapiens (Human)
SMAD1_HUMAN SMAD1 199 206 PNSPGSSSSTYPHSPTSSDP TP 4 Homo sapiens (Human)
SMAD3_HUMAN SMAD3 201 208 QMNHSMDAGSPNLSPNPMSP TP 3 Homo sapiens (Human)
1 
MK67I_HUMAN MKI67IP 227 234 LDTPEKTVDSQGPTPVCTPT TP 3 Homo sapiens (Human)
2 
MK67I_HUMAN MKI67IP 231 238 EKTVDSQGPTPVCTPTFLER TP 3 Homo sapiens (Human)
2 
FGD3_HUMAN FGD3 77 84 IPNRDSGIDSPSSSVAGENF TP 2 Homo sapiens (Human)
2 
FGD3_HUMAN FGD3 73 80 GSLKIPNRDSGIDSPSSSVA TP 5 Homo sapiens (Human)
2 
HSF1_HUMAN HSF1 300 307 LVRVKEEPPSPPQSPRVEEA TP 3 Homo sapiens (Human)
CCNE1_HUMAN CCNE1 388 395 EQNRASPLPSGLLTPPQSGK TP 1 Homo sapiens (Human)
2 
MYC_HUMAN MYC 55 62 IWKKFELLPTPPLSPSRRSG TP 3 Homo sapiens (Human)
2 
2 
FGD1_HUMAN FGD1 280 287 DGEKVPNRDSGIDSISSPSN TP 1 Homo sapiens (Human)
1 
CCNE1_HUMAN CCNE1 373 380 EQNRASPLPSGLLTPPQSGK TP 4 Homo sapiens (Human)
1 
ESR2_HUMAN ESR2 5 12 MDIKNSPSSLNSPSSYNCSQ TP 3 Homo sapiens (Human)
1 
CTNB1_MOUSE Ctnnb1 30 37 HWQQQSYLDSGIHSGATTTA TP 2 Mus musculus (House mouse)
CTNB1_HUMAN CTNNB1 30 37 HWQQQSYLDSGIHSGATTTA TP 4 Homo sapiens (Human)
2 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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