MOD_GSK3_1
| Accession: | |
|---|---|
| Functional site class: | GSK3 phosphorylation site |
| Functional site description: | Site recognised by GSK3 for Ser/Thr phosphorylation. |
| ELM Description: | The GSK3 phosphorylation recognition site is based primarily on Vertebrata data. GSK3-family kinases are widespread in Bacteria759 but in most cases the specificity has not been confirmed. |
| Pattern: | ...([ST])...[ST] |
| Pattern Probability: | 0.0267866 |
| Present in taxon: | Eukaryota |
| Interaction Domain: |
Pkinase (PF00069)
Protein kinase domain
(Stochiometry: 1 : 1)
|
 Abstract |
GSK3 comprises two highly related proteins (GSK3-alpha and GSK3-beta) that phosphorylate a wide variety of target proteins. This kinase is expressed consitutively active in resting cells, and phosphorylation of several substrates is inhibitory, suggesting this protein kinase may repress target protein function by phosphorylation. Major targets include Glycogen synthase, ATP citrate lysate, c-Jun, c-Myc, L-Myc and tau protein suggesting roles in the control of several different biochemical pathways. |
4 GO-Terms:
22 Instances for MOD_GSK3_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement