ELM - instance MOD_GSK3_1 in sequence P24864-3 at position 373

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002602	P24864-3 CCNE1 CCNE1_HUMAN	373	380	EQNRASPLPSGLLTPPQSGK	TP	---	Homo sapiens (Human)	395

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0586	inhibitor		Welcker,2003	support	certain
experimental	MI:0424	protein kinase assay	in vitro	Welcker,2003	support	certain	InteractionDetection
experimental	MI:0424	protein kinase assay	in vivo	Welcker,2003	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Welcker,2003	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000278:

Phosphorylation of Isoform E-S of G1/S-specific cyclin-E1 (CCNE1) at S384 by CDK2 primes CCNE1 for phosphorylation by Glycogen synthase kinase-3 beta (GSK3B) at S380, which creates a recognition site for F box proteins of the SCF ubiquitin ligase complex (F-box/WD repeat-containing protein 7 (FBXW7)) that target CCNE1 for degradation.

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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