ELM - instance MOD_GSK3_1 in sequence P54252 at position 253

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001861	P54252 ATXN3 ATX3_HUMAN	253	260	ADLRRAIQLSMQGSSRNISQ	TP	---	Homo sapiens (Human)	364

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0074	mutation analysis	in vivo/in vitro	Fei,2007	support	likely	FeatureDetection
experimental	MI:0424	protein kinase assay	in vivo	Fei,2007	support	likely	InteractionDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(P49841) GSK3B_HUMAN	PF00069 (Pkinase) Protein kinase domain	56	340		[mitab][xml]

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000019:

Phosphorylation of Ataxin-3 (ATXN3) at S260 primes the protein for subsequent phosphorylation at S256 by Glycogen synthase kinase-3 beta (GSK3B).

Pathways

KEGG: The sequence P54252 is implicated in the following 3 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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