| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001862 | P01106 MYC MYC_HUMAN |
55 | 62 | IWKKFELLPTPPLSPSRRSG | TP | --- | Homo sapiens (Human) | 439 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Gregory,2003 | support | certain | InteractionDetection |
| experimental | MI:0113 | western blot | in vitro | Gregory,2003 | support | certain | ParticipantIdentification FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P49840) GSK3A_HUMAN | PF00069
(Pkinase)
Protein kinase domain |
119 | 403 | [mitab][xml] | |
| (P49841) GSK3B_HUMAN | PF00069
(Pkinase)
Protein kinase domain |
56 | 340 | [mitab][xml] |
Switches
This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:
-
SWTI000015:
Phosphorylation of Myc proto-oncogene protein (MYC) at S62 primes the protein for phosphorylation at T58 by Glycogen synthase kinase-3 beta (GSK3B).
-
SWTI000285:
Phosphorylation of Myc proto-oncogene protein (MYC) at S62 by Mitogen-activated protein kinase 1 (MAPK1) primes MYC for phosphorylation by Glycogen synthase kinase-3 beta (GSK3B), which targets MYC to the SCF ubiquitin ligase complex, F-box/WD repeat-containing protein 7 (FBXW7) that marks MYC for degradation.
Pathways
- Acute myeloid leukemia
- Bladder cancer
- Breast cancer
- Cell cycle
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis receptor activation
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- Epstein Barr virus infection
- ErbB signaling pathway
- Gastric cancer
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human T cell leukemia virus 1 infection
- Human cytomegalovirus infection
- JAK STAT signaling pathway
- Kaposi sarcoma associated herpesvirus infection
- MAPK signaling pathway
- MicroRNAs in cancer
- PI3K Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Salmonella infection
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- TGF beta signaling pathway
- Thyroid cancer
- Thyroid hormone signaling pathway
- Transcriptional misregulation in cancer
- Wnt signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement