| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001859 | P04637 TP53 P53_HUMAN |
30 | 37 | KLLPENNVLSPLPSQAMDDL | TP | --- | Homo sapiens (Human) | 393 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Turenne,2001 | support | likely | FeatureDetection |
| experimental | MI:0424 | protein kinase assay | in vivo | Turenne,2001 | support | likely | InteractionDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P49841) GSK3B_HUMAN | PF00069
(Pkinase)
Protein kinase domain |
56 | 340 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000016:
Phosphorylation of Cellular tumor antigen p53 (TP53) at S37 primes the protein for phosphorylation at S33 by Glycogen synthase kinase-3 beta (GSK3B).
Pathways
- Amyotrophic lateral sclerosis
- Apoptosis
- Basal cell carcinoma
- Bladder cancer
- Breast cancer
- Cell cycle
- Cellular senescence
- Central carbon metabolism in cancer
- Chronic myeloid leukemia
- Colorectal cancer
- Endocrine resistance
- Endometrial cancer
- Epstein Barr virus infection
- Ferroptosis
- Fluid shear stress and atherosclerosis
- Gastric cancer
- Glioma
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Human T cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Huntington disease
- Kaposi sarcoma associated herpesvirus infection
- Lipid and atherosclerosis
- Longevity regulating pathway
- MAPK signaling pathway
- Measles
- Melanoma
- MicroRNAs in cancer
- Mitophagy animal
- Neurotrophin signaling pathway
- Non small cell lung cancer
- PI3K Akt signaling pathway
- Pancreatic cancer
- Parkinson disease
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Shigellosis
- Small cell lung cancer
- Sphingolipid signaling pathway
- Thyroid cancer
- Thyroid hormone signaling pathway
- Transcriptional misregulation in cancer
- Viral carcinogenesis
- Wnt signaling pathway
- p53 signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement