MOD_GSK3_1
53
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| Functional site class: | GSK3 phosphorylation site |
| Functional site description: | Site recognised by GSK3 for Ser/Thr Phosphorylation |
|---|---|
| ELMs: | MOD_GSK3_1 |
| Description: | The GSK3 phosphorylation recognition site is based primarily on vertebrate data. GSK3-family kinases are widespread in Eukaryota but in most cases the specificity has not been confirmed. |
| Pattern: | ...([ST])...[ST] (Probability: 0.0267866) |
| Present in taxons: | Eukaryota |
| Interaction Domain: |
Pkinase (PF00069) |
See 5 Instances for MOD_GSK3_1
|
| GSK3 comprises two highly related proteins (GSK3-alpha and GSK3-beta) that phosphorylate a wide variety of target proteins. This kinase is expressed consitutively active in resting cells, and phosphorylation of several substrates is inhibitory suggesting this protein kinase may repress target protein function by phosphorylation. Major targets include Glycogen synthase, ATP citrate lysate, c-Jun, c-Myc, L-Myc and tau protein suggesting roles in the control of several different biochemical pathways |
4 GO-Terms:
5 Instances for MOD_GSK3_1
(click table headers for sorting)
| Sequence | Start | End | Subsequence | Instance Logic | PDB | Organism |
|---|---|---|---|---|---|---|
| CCNE1_HUMAN | 392 | 399 | ASPLPSGLLTPPQSGKKQSS | true positive | --- | Homo sapiens (Human) |
| MYC_HUMAN | 55 | 62 | IWKKFELLPTPPLSPSRRSG | true positive | --- | Homo sapiens (Human) |
| ATX3_HUMAN | 253 | 260 | ADLRRAIQLSMQGSSRNISQ | true positive | --- | Homo sapiens (Human) |
| JUN_HUMAN | 236 | 243 | QTVPEMPGETPPLSPIDMES | true positive | --- | Homo sapiens (Human) |
| P53_HUMAN | 30 | 37 | KLLPENNVLSPLPSQAMDDL | true positive | --- | Homo sapiens (Human) |
Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)