The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
SH3 ligand
Functional site description:
This motif is involved in protein-protein interaction mediated by SH3 domains.
ELMs with same func. site: LIG_SH3_1  LIG_SH3_2  LIG_SH3_3  LIG_SH3_4  LIG_SH3_5 
ELM Description:
this is the motif recognized by class II SH3 domains
Pattern: P..P.[KR]
Pattern Probability: 0.0011112
Present in taxons: Bos taurus Gallus gallus Homo sapiens Komagataella pastoris Mus musculus Opisthokonta Rattus norvegicus Saccharomyces cerevisiae
Interaction Domains:
PDB Structure: 1JEG
<a href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JEG" title="" target="_blank"><img src="/media/pdb.ico.png"/>1JEG</a>
o See 19 Instances for LIG_SH3_2
o Abstract
SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. Ligand orientation depends on the position of the positive residue in the target peptide. Peptides that bind in a type I orientation contain the consensus R/KXXPXXP, while the type II orientation conform to the PXXPXR/K consensus.
o 19 selected references:

o 10 GO-Terms:

o 19 Instances for LIG_SH3_2
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
Q07889 SOS1
SOS1_HUMAN
1152 1157 DEVPVPPPVPPRRRPESAPA TP 2 Homo sapiens (Human)
P35465 Pak1
PAK1_RAT
13 18 LDVQDKPPAPPMRNTSTMIG TP 1 Rattus norvegicus (Norway rat)
P29352 Ptpn22
PTN22_MOUSE
614 619 RTDDEIPPPLPERTPESFIV TP 3 Mus musculus (House mouse)
P03406 nef
NEF_HV1BR
72 77 EVGFPVTPQVPLRPMTYKAA TP 3 Human immunodeficiency virus type 1 (BRU ISOLATE)
P53112 PEX14
PEX14_YEAST
87 92 YLYEAMPPTLPHRDWKDYFV TP 3 Saccharomyces cerevisiae (Baker"s yeast)
Q13905 RAPGEF1
RPGF1_HUMAN
284 289 VVDNSPPPALPPKKRQSAPS TP 1 Homo sapiens (Human)
P27986 PIK3R1
P85A_HUMAN
305 310 WNERQPAPALPPKPPKPTTV TP 2 Homo sapiens (Human)
P27986 PIK3R1
P85A_HUMAN
308 313 RQPAPALPPKPPKPTTVANN TP 1 Homo sapiens (Human)
Q05193 DNM1
DYN1_HUMAN
833 838 FGPPPQVPSRPNRAPPGVPS TP 1 Homo sapiens (Human)
P34152 Ptk2
FAK1_MOUSE
750 755 SGGSDEAPPKPSRPGYPSPR TP 4 Mus musculus (House mouse)
P26662 
POLG_HCVJA
2323 2328 LPSTKAPPIPPPRRKRTVVL TP 7 Hepatitis C virus (isolate Japanese)
1 
P14598 NCF1
NCF1_HUMAN
363 368 TQRSKPQPAVPPRPSADLIL TP 2 Homo sapiens (Human)
P01106 MYC
MYC_HUMAN
60 65 FELLPTPPLSPSRRSGLCSP TP 2 Homo sapiens (Human)
2 
P50570 DNM2
DYN2_HUMAN
829 834 SDLFPAPPQIPSRPVRIPPG TP 4 Homo sapiens (Human)
1 
1 
Q05397 PTK2
FAK1_HUMAN
712 717 SGGSDEAPPKPSRPGYPSPR TP 4 Homo sapiens (Human)
Q13153 PAK1
PAK1_HUMAN
13 18 LDIQDKPPAPPMRNTSTMIG TP 3 Homo sapiens (Human)
1 
1 
Q13444 ADAM15
ADA15_HUMAN
767 772 QASALSFPAPPSRPLPPDPV TP 3 Homo sapiens (Human)
1 
Q07889 SOS1
SOS1_HUMAN
1151 1156 TDEVPVPPPVPPRRRPESAP TP 4 Homo sapiens (Human)
1 
O55207 Synj2
SYNJ2_RAT
1120 1125 VPNRPRPPHPPQRPPPPTGL TP 5 Rattus norvegicus (Norway rat)
5 
1 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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