The Eukaryote Linear Motif resource for Functional Sites in Proteins
LIG_SH3_2 6
 
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Functional site class: SH3 ligand
Functional site description: This motif is involved in protein-protein interaction mediated by SH3 domains
ELMs: LIG_SH3_1 LIG_SH3_2 LIG_SH3_3 LIG_SH3_4 LIG_SH3_5
Description: this is the motif recognized by class II SH3 domains
Pattern: P..P.[KR] (Probability: 0.0011112)
Present in taxons: Bos taurus Gallus gallus Homo sapiens Komagataella pastoris Mus musculus Opisthokonta Rattus norvegicus Saccharomyces cerevisiae
PDB Structure: 1CKA
<img src="/media/pdb.ico.png"/><a href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1CKA" target="_blank">1CKA</a>
Interaction Domain:

SH3_1 (PF00018)
SH3 domain
(Stochiometry: 1 : 1)

SH3_2 (PF07653)
Variant SH3 domain
(Stochiometry: 1 : 1)

o See 18 Instances for LIG_SH3_2


o Abstract

SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. Ligand orientation depends on the position of the positive residue in the target peptide. Peptides that bind in a type I orientation contain the consensus R/KXXPXXP, while the type II orientation conform to the PXXPXR/K consensus

o 19 selected references:

o 10 GO-Terms:

o 18 Instances for LIG_SH3_2
(click table headers for sorting)
SequenceStartEndSubsequence
Instance LogicPDB Organism
SOS1_HUMAN 1151 1156 TDEVPVPPPVPPRRRPESAP true positive --- Homo sapiens (Human)
SOS1_HUMAN 1152 1157 DEVPVPPPVPPRRRPESAPA true positive --- Homo sapiens (Human)
PAK1_RAT 13 18 LDVQDKPPAPPMRNTSTMIG true positive --- Rattus norvegicus (Norway rat)
PTN22_MOUSE 614 619 RTDDEIPPPLPERTPESFIV true positive 1JEG
 Mus musculus (House mouse)
NEF_HV1BR 72 77 EVGFPVTPQVPLRPMTYKAA true positive 1EFN
 Human immunodeficiency virus type 1 (BRU ISOLATE)
PEX14_YEAST 87 92 YLYEAMPPTLPHRDWKDYFV true positive 1N5Z
 Saccharomyces cerevisiae (Baker"s yeast)
RPGF1_HUMAN 284 289 VVDNSPPPALPPKKRQSAPS true positive 1CKA
 Homo sapiens (Human)
P85A_HUMAN 305 310 WNERQPAPALPPKPPKPTTV true positive --- Homo sapiens (Human)
P85A_HUMAN 308 313 RQPAPALPPKPPKPTTVANN true positive --- Homo sapiens (Human)
DYN1_HUMAN 833 838 FGPPPQVPSRPNRAPPGVPS true positive --- Homo sapiens (Human)
FAK1_MOUSE 750 755 SGGSDEAPPKPSRPGYPSPR true positive --- Mus musculus (House mouse)
POLG_HCVJA 2323 2328 LPSTKAPPIPPPRRKRTVVL true positive --- Hepatitis C virus (isolate Japanese)
NCF1_HUMAN 363 368 TQRSKPQPAVPPRPSADLIL true positive 1W70
 Homo sapiens (Human)
MYC_HUMAN 60 65 FELLPTPPLSPSRRSGLCSP true positive 1MV0
 Homo sapiens (Human)
DYN2_HUMAN 829 834 SDLFPAPPQIPSRPVRIPPG true positive --- Homo sapiens (Human)
FAK1_HUMAN 712 717 SGGSDEAPPKPSRPGYPSPR true positive --- Homo sapiens (Human)
PAK1_HUMAN 13 18 LDIQDKPPAPPMRNTSTMIG true positive --- Homo sapiens (Human)
ADA15_HUMAN 767 772 QASALSFPAPPSRPLPPDPV true positive --- Homo sapiens (Human)

Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)

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