The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
SH3 ligand
Functional site description:
This motif is involved in protein-protein interaction mediated by SH3 domains.
ELMs with same func. site: LIG_SH3_1  LIG_SH3_2  LIG_SH3_3  LIG_SH3_4  LIG_SH3_5 
ELM Description:
this is the motif recognized by class II SH3 domains
Pattern: P..P.[KR]
Pattern Probability: 0.0011112
Present in taxons: Bos taurus Gallus gallus Homo sapiens Komagataella pastoris Mus musculus Opisthokonta Rattus norvegicus Saccharomyces cerevisiae
Interaction Domains:
PDB Structure: 1EFN
<a href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1EFN" title="" target="_blank"><img src="/media/pdb.ico.png"/>1EFN</a>
o See 19 Instances for LIG_SH3_2
o Abstract
SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. Ligand orientation depends on the position of the positive residue in the target peptide. Peptides that bind in a type I orientation contain the consensus R/KXXPXXP, while the type II orientation conform to the PXXPXR/K consensus.
o 19 selected references:

o 10 GO-Terms:

o 19 Instances for LIG_SH3_2
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
SOS1_HUMAN SOS1 1152 1157 DEVPVPPPVPPRRRPESAPA TP 2 Homo sapiens (Human)
PAK1_RAT Pak1 13 18 LDVQDKPPAPPMRNTSTMIG TP 1 Rattus norvegicus (Norway rat)
PTN22_MOUSE Ptpn22 614 619 RTDDEIPPPLPERTPESFIV TP 3 Mus musculus (House mouse)
NEF_HV1BR nef 72 77 EVGFPVTPQVPLRPMTYKAA TP 3 Human immunodeficiency virus type 1 (BRU ISOLATE)
PEX14_YEAST PEX14 87 92 YLYEAMPPTLPHRDWKDYFV TP 3 Saccharomyces cerevisiae (Baker"s yeast)
RPGF1_HUMAN RAPGEF1 284 289 VVDNSPPPALPPKKRQSAPS TP 1 Homo sapiens (Human)
P85A_HUMAN PIK3R1 305 310 WNERQPAPALPPKPPKPTTV TP 2 Homo sapiens (Human)
P85A_HUMAN PIK3R1 308 313 RQPAPALPPKPPKPTTVANN TP 1 Homo sapiens (Human)
DYN1_HUMAN DNM1 833 838 FGPPPQVPSRPNRAPPGVPS TP 1 Homo sapiens (Human)
FAK1_MOUSE Ptk2 750 755 SGGSDEAPPKPSRPGYPSPR TP 4 Mus musculus (House mouse)
POLG_HCVJA 2323 2328 LPSTKAPPIPPPRRKRTVVL TP 7 Hepatitis C virus (isolate Japanese)
1 
NCF1_HUMAN NCF1 363 368 TQRSKPQPAVPPRPSADLIL TP 2 Homo sapiens (Human)
MYC_HUMAN MYC 60 65 FELLPTPPLSPSRRSGLCSP TP 2 Homo sapiens (Human)
2 
DYN2_HUMAN DNM2 829 834 SDLFPAPPQIPSRPVRIPPG TP 4 Homo sapiens (Human)
1 
1 
FAK1_HUMAN PTK2 712 717 SGGSDEAPPKPSRPGYPSPR TP 4 Homo sapiens (Human)
PAK1_HUMAN PAK1 13 18 LDIQDKPPAPPMRNTSTMIG TP 3 Homo sapiens (Human)
1 
1 
ADA15_HUMAN ADAM15 767 772 QASALSFPAPPSRPLPPDPV TP 3 Homo sapiens (Human)
1 
SOS1_HUMAN SOS1 1151 1156 TDEVPVPPPVPPRRRPESAP TP 4 Homo sapiens (Human)
1 
SYNJ2_RAT Synj2 1120 1125 VPNRPRPPHPPQRPPPPTGL TP 5 Rattus norvegicus (Norway rat)
5 
1 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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