The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002131 P50570 DNM2
DYN2_HUMAN
829 834 SDLFPAPPQIPSRPVRIPPG TP --- Homo sapiens (Human) 870

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Kojima,2004 support certain
experimental MI:0077 nuclear magnetic resonance in vitro Kojima,2004 support certain InteractionDetection FeatureDetection
experimental MI:0405 competition binding in vitro Kojima,2004 support certain InteractionDetection
experimental MI:0107 surface plasmon resonance in vitro Kojima,2004 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O00499) BIN1_HUMAN PF07653 (SH3_2)
Variant SH3 domain
524 590 [mitab][xml]

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
  • SWTI000328:
    ELM Switch SWTI000328

    An intramolecular interaction of a Bin1 SH3 binding motif, encoded by exon 10, with the Dynamin-2 (DNM2) SH3 domain prevents binding of dynamin2 to the Bin1 SH3 domain. Binding of PI(4,5)P2 to the overlapping PI(4,5)P2 binding motif encoded by exon 10 relieves the intramolecular auto-inhibitory interaction and allows the Bin1 SH3 domain to interact with the dynamin2 PxxP motif

o  Pathways

KEGG: The sequence P50570 is implicated in the following 5 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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