| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002173 | Q13153 PAK1 PAK1_HUMAN |
13 | 18 | LDIQDKPPAPPMRNTSTMIG | TP | --- | Homo sapiens (Human) | 545 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
| experimental | MI:0519 | glutathione s tranferase tag | in vitro | Galisteo,1996 | support | certain | |
| experimental | MI:0018 | two hybrid | in vivo | Galisteo,1996 | support | certain | InteractionDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Galisteo,1996 | support | certain | FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P16333) NCK1_HUMAN | PF00018
(SH3_1)
SH3 domain |
[mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000197:
Phosphorylation of S21 adjacent to the SH3-binding motif of Serine/threonine-protein kinase PAK 1 (PAK1) by RAC subfamily inhibits binding to Cytoplasmic protein NCK1 (NCK1), which regulates its localization to focal contacts.
Pathways
- Axon guidance
- C type lectin receptor signaling pathway
- Chemokine signaling pathway
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Fc gamma R mediated phagocytosis
- Focal adhesion
- Hippo signaling pathway multiple species
- Human immunodeficiency virus 1 infection
- MAPK signaling pathway
- Natural killer cell mediated cytotoxicity
- Pathogenic Escherichia coli infection
- Proteoglycans in cancer
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- Salmonella infection
- T cell receptor signaling pathway
- cAMP signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement