The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002173 Q13153 PAK1
PAK1_HUMAN
13 18 LDIQDKPPAPPMRNTSTMIG TP --- Homo sapiens (Human) 545

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Galisteo,1996 support certain
experimental MI:0018 two hybrid in vivo Galisteo,1996 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Galisteo,1996 support certain FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P16333) NCK1_HUMAN PF00018 (SH3_1)
SH3 domain
[mitab][xml]

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence Q13153 is implicated in the following 14 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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