The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Functional site class:
SH3 ligand
Functional site description:
This motif is involved in protein-protein interaction mediated by SH3 domains.
ELMs with same func. site: LIG_SH3_1  LIG_SH3_2  LIG_SH3_3  LIG_SH3_4  LIG_SH3_5 
ELM Description:
This is the motif recognized by class I SH3 domains
Pattern: [RKY]..P..P
Pattern Probability: 0.0012370
Present in taxons: Bos taurus Gallus gallus Homo sapiens Mus musculus Opisthokonta Rattus norvegicus Saccharomyces cerevisiae
Interaction Domain:
SH3_1 (PF00018) SH3 domain (Stochiometry: 1 : 1)
o See 8 Instances for LIG_SH3_1
o Abstract
SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. Ligand orientation depends on the position of the positive residue in the target peptide. Peptides that bind in a type I orientation contain the consensus R/KXXPXXP, while the type II orientation conform to the PXXPXR/K consensus.
o 20 selected references:

o 10 GO-Terms:

o 8 Instances for LIG_SH3_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
B7UM88 espF
169 175 VSFKPTRQAPPPPTSGQASG TP 7 Escherichia coli O127:H6 str. E2348/69
B7UM88 espF
122 128 VNFKPTRPAPPPPTSGQASG TP 9 Escherichia coli O127:H6 str. E2348/69
B7UM88 espF
75 81 TSFTPSRPAPPPPTSGQASG TP 9 Escherichia coli O127:H6 str. E2348/69
Q06609 RAD51
315 321 TRICKIYDSPCLPEAEAMFA TP 3 Homo sapiens (Human)
P10636 MAPT
547 553 KKVAVVRTPPKSPSSAKSRL TP 1 Homo sapiens (Human)
Q06187 BTK
200 206 EDQILKKPLPPEPAAAPVST TP 1 Homo sapiens (Human)
Q06187 BTK
186 192 SHRKTKKPLPPTPEEDQILK TP 1 Homo sapiens (Human)
P27986 PIK3R1
88 94 ISPPTPKPRPPRPLPVAPGS TP 2 Homo sapiens (Human)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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