The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI000183 Q07889 SOS1
SOS1_HUMAN
1151 1156 TDEVPVPPPVPPRRRPESAP TP --- Homo sapiens (Human) 1333

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0065 isothermal titration calorimetry in vitro McDonald,2013 support certain InteractionDetection
experimental MI:0405 competition binding in vitro McDonald,2013 support certain InteractionDetection
experimental MI:0096 pull down in vivo/in vitro Li,1993 support likely InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Li,1993 support likely InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P62993) GRB2_HUMAN PF00018 (SH3_1)
SH3 domain
4 50 [mitab][xml]

o  Pathways

KEGG: The sequence Q07889 is implicated in the following 33 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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