| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI000183 | Q07889 SOS1 SOS1_HUMAN |
1151 | 1156 | TDEVPVPPPVPPRRRPESAP | TP | --- | Homo sapiens (Human) | 1333 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0065 | isothermal titration calorimetry | in vitro | McDonald,2013 | support | certain | InteractionDetection |
| experimental | MI:0405 | competition binding | in vitro | McDonald,2013 | support | certain | InteractionDetection |
| experimental | MI:0096 | pull down | in vivo/in vitro | Li,1993 | support | likely | InteractionDetection |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Li,1993 | support | likely | InteractionDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P62993) GRB2_HUMAN | PF00018
(SH3_1)
SH3 domain |
4 | 50 | [mitab][xml] |
Pathways
- Acute myeloid leukemia
- Alcoholism
- B cell receptor signaling pathway
- Breast cancer
- Chemical carcinogenesis reactive oxygen species
- Chemical carcinogenesis receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Chronic myeloid leukemia
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human papillomavirus infection
- Insulin signaling pathway
- JAK STAT signaling pathway
- MAPK signaling pathway
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non small cell lung cancer
- PI3K Akt signaling pathway
- Pathways in cancer
- Phospholipase D signaling pathway
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- T cell receptor signaling pathway
- Thermogenesis
- mTOR signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement