LIG_SH3_2
| Accession: | |
|---|---|
| Functional site class: | SH3 ligand |
| Functional site description: | This motif is involved in protein-protein interaction mediated by SH3 domains. |
| ELMs with same func. site: | LIG_SH3_1 LIG_SH3_2 LIG_SH3_3 LIG_SH3_4 LIG_SH3_5 |
| ELM Description: | this is the motif recognized by class II SH3 domains |
| Pattern: | P..P.[KR] |
| Pattern Probability: | 0.0011112 |
| Present in taxons: | Bos taurus Gallus gallus Homo sapiens Komagataella pastoris Mus musculus Opisthokonta Rattus norvegicus Saccharomyces cerevisiae |
| Interaction Domains: |
|
 Abstract |
SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. Ligand orientation depends on the position of the positive residue in the target peptide. Peptides that bind in a type I orientation contain the consensus R/KXXPXXP, while the type II orientation conform to the PXXPXR/K consensus. |
19 selected references:
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Interaction between focal adhesion kinase and Crk-associated tyrosine
kinase substrate p130Cas.
Polte TR, Hanks SK
Proc Natl Acad Sci U S A 1995 Nov 7; 92 (23), 10678-82
PMID: 7479864
-
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor
tyrosine kinases to Ras signalling.
Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, Schlessinger J
Nature 1993 May 6; 363 (6424), 85-8
PMID: 8479541
-
p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal
adhesions and binds to focal adhesion kinase.
Harte MT, Hildebrand JD, Burnham MR, Bouton AH, Parsons JT
J Biol Chem 1996 Jun 7; 271 (23), 13649-55
PMID: 8662921
-
Specificity of p47phox SH3 domain interactions in NADPH oxidase assembly
and activation.
de Mendez I, Homayounpour N, Leto TL
Mol Cell Biol 1997 Apr; 17 (4), 2177-85
PMID: 9121467
-
NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates
the SAPK/JNK cascade via a conserved regulatory domain.
Su YC, Han J, Xu S, Cobb M, Skolnik EY
EMBO J 1997 Mar 17; 16 (6), 1279-90
PMID: 9135144
-
The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at
a single site that defines a new SH3 binding consensus sequence.
Grabs D, Slepnev VI, Songyang Z, David C, Lynch M, Cantley LC, De Camilli P
J Biol Chem 1997 May 16; 272 (20), 13419-25
PMID: 9148966
-
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2.
Xu XX, Yi T, Tang B, Lambeth JD
Oncogene 1998 Mar 26; 16 (12), 1561-9
PMID: 9569023
-
Sequence requirements for association of protein-tyrosine phosphatase PEP
with the Src homology 3 domain of inhibitory tyrosine protein kinase
p50(csk).
Gregorieff A, Cloutier JF, Veillette A
J Biol Chem 1998 May 22; 273 (21), 13217-22
PMID: 9582365
-
Involvement of Pex13p in Pex14p localization and peroxisomal targeting
signal 2-dependent protein import into peroxisomes.
Girzalsky W, Rehling P, Stein K, Kipper J, Blank L, Kunau WH, Erdmann R
J Cell Biol 1999 Mar 22; 144 (6), 1151-62
PMID: 10087260
-
Evidence for SH3 domain directed binding and phosphorylation of Sam68 by
Src.
Shen Z, Batzer A, Koehler JA, Polakis P, Schlessinger J, Lydon NB, Moran MF
Oncogene 1999 Aug 19; 18 (33), 4647-53
PMID: 10467411
-
The SH3 domains of endophilin and amphiphysin bind to the proline-rich
region of synaptojanin 1 at distinct sites that display an unconventional
binding specificity.
Cestra G, Castagnoli L, Dente L, Minenkova O, Petrelli A, Migone N, Hoffmuller U, Schneider-Mergener J, Cesareni G
J Biol Chem 1999 Nov 5; 274 (45), 32001-7
PMID: 10542231
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The importance of being proline: the interaction of proline-rich motifs in
signaling proteins with their cognate domains.
Kay BK, Williamson MP, Sudol M
FASEB J 2000 Feb; 14 (2), 231-41
PMID: 10657980
-
Interaction of Pex5p, the type 1 peroxisome targeting signal receptor,
with the peroxisomal membrane proteins Pex14p and Pex13p.
Urquhart AJ, Kennedy D, Gould SJ, Crane DI
J Biol Chem 2000 Feb 11; 275 (6), 4127-36
PMID: 10660573
-
Interaction between PAK and nck: a template for Nck targets and role of
PAK autophosphorylation.
Zhao ZS, Manser E, Lim L
Mol Cell Biol 2000 Jun; 20 (11), 3906-17
PMID: 10805734
-
The calcineurin-binding protein cain is a negative regulator of synaptic
vesicle endocytosis.
Lai MM, Luo HR, Burnett PE, Hong JJ, Snyder SH
J Biol Chem 2000 Nov 3; 275 (44), 34017-20
PMID: 10931822
-
Direct binding of activated c-Src to the beta 3-adrenergic receptor is
required for MAP kinase activation.
Cao W, Luttrell LM, Medvedev AV, Pierce KL, Daniel KW, Dixon TM, Lefkowitz RJ, Collins S
J Biol Chem 2000 Dec 8; 275 (49), 38131-4
PMID: 11013230
-
Meltrin alpha cytoplasmic domain interacts with SH3 domains of Src and
Grb2 and is phosphorylated by v-Src.
Suzuki A, Kadota N, Hara T, Nakagami Y, Izumi T, Takenawa T, Sabe H, Endo T
Oncogene 2000 Nov 30; 19 (51), 5842-50
PMID: 11127814
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SH3 domains: complexity in moderation.
Mayer BJ
J Cell Sci 2001 Apr; 114, 1253-63
PMID: 11256992
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Progesterone receptor contains a proline-rich motif that directly
interacts with SH3 domains and activates c-Src family tyrosine kinases.
Boonyaratanakornkit V, Scott MP, Ribon V, Sherman L, Anderson SM, Maller JL, Miller WT, Edwards DP
Mol Cell 2001 Aug; 8 (2), 269-80
PMID: 11545730
10 GO-Terms:
19 Instances for LIG_SH3_2
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement