The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
MAPK Phosphorylation Site
Functional site description:
Site at which MAP Kinase phosphorylates substrates.
ELM Description:
(S/T)P site at which Pro-directed kinases such as P38 MAP Kinase phosphorylate a Ser/Thr residue in various signal transduction pathways. These kinases require a docking motif to be activated, so the site is not meaningful by itself. MAP Kinase homologues are found widely in eukaryotes, including protozoa, but experimental data is from higher eukaryotes, mainly metazoa.
Pattern: ...([ST])P..
Pattern Probability: 0.0154332
Present in taxons: Drosophila melanogaster Eukaryota Vertebrata
Interaction Domain:
Pkinase (PF00069) Protein kinase domain (Stochiometry: 1 : 1)
o See 36 Instances for MOD_ProDKin_1
o Abstract
Proline-directed kinases phosphorylate a Ser/Thr residue preceding a Pro residue. This low specificity site is recognised by a large family of MAP and CDK-like kinases. However, the kinases achieve their target substrate specificity through separate docking motifs, which are also required to activate the kinase enzymatic function. A docking motif should be present in a candidate substrate sequence - or any (S/T)P motif is unlikely to be meaningful. For example, the P38 MAP kinase is activated by motifs approximating to [RK]XXXX#X# where # is a hydrophobic residue (Chang,2002) and ERK kinase is also activated by FxFP-like motifs (Fantz,2001).
o 5 GO-Terms:

o 36 Instances for MOD_ProDKin_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P10276 RARA
RARA_HUMAN
178 184 PECSESYTLTPEVGELIEKV TP 4 Homo sapiens (Human)
P10276 RARA
RARA_HUMAN
442 448 GLAPPPGSCSPSLSPSSNRS TP 4 Homo sapiens (Human)
P28324 ELK4
ELK4_HUMAN
378 384 SSIHFWSTLSPVAPLSPARL TP 4 Homo sapiens (Human)
P97875 Jdp2
JDP2_MOUSE
145 151 CIVRTDSVRTPESEGNPLLE TP 3 Mus musculus (House mouse)
P41212 ETV6
ETV6_HUMAN
254 260 SSESHPKPSSPRQESTRVIQ TP 3 Homo sapiens (Human)
P05787 KRT8
K2C8_HUMAN
71 77 AVTVNQSLLSPLVLEVDPNI TP 5 Homo sapiens (Human)
P17542 TAL1
TAL1_HUMAN
119 125 PGDGRMVQLSPPALAAPAAP TP 3 Homo sapiens (Human)
A6P3E3 Ncoa2
A6P3E3_MOUSE
733 739 EVTVKQEPASPKKKENALLR TP 4 Mus musculus (House mouse)
P06240 Lck
LCK_MOUSE
56 62 TYEGSLPPASPLQDNLVIAL TP 7 Mus musculus (House mouse)
P08047 SP1
SP1_HUMAN
736 742 AGSEGSGTATPSALITTNMV TP 4 Homo sapiens (Human)
P26630 pax6a
PAX6_DANRE
410 416 SGTTSTGLISPGVSVPVQVP TP 4 Danio rerio (Zebrafish)
P28324 ELK4
ELK4_HUMAN
384 390 STLSPVAPLSPARLQGANTL TP 4 Homo sapiens (Human)
P08047 SP1
SP1_HUMAN
450 456 PNSGPIIIRTPTVGPNGQVS TP 4 Homo sapiens (Human)
P50616 TOB1
TOB1_HUMAN
151 157 PASSVSSSPSPPFGHSAAVS TP 4 Homo sapiens (Human)
Q05397 PTK2
FAK1_HUMAN
907 913 GVKLQPQEISPPPTANLDRS TP 4 Homo sapiens (Human)
Q07889 SOS1
SOS1_HUMAN
1164 1170 RPESAPAESSPSKIMSKHLD TP 4 Homo sapiens (Human)
Q07889 SOS1
SOS1_HUMAN
1175 1181 SKIMSKHLDSPPAIPPRQPT TP 4 Homo sapiens (Human)
Q07889 SOS1
SOS1_HUMAN
1190 1196 PRQPTSKAYSPRYSISDRTS TP 4 Homo sapiens (Human)
Q13322 GRB10
GRB10_HUMAN
147 153 PFPELCGPGSPPVLTPGSLP TP 4 Homo sapiens (Human)
Q13322 GRB10
GRB10_HUMAN
473 479 TRMNILGSQSPLHPSTLSTV TP 4 Homo sapiens (Human)
Q14934 NFATC4
NFAC4_HUMAN
165 171 GGQGGGAFFSPSPGSSSLSS TP 5 Homo sapiens (Human)
Q14934 NFATC4
NFAC4_HUMAN
167 173 QGGGAFFSPSPGSSSLSSWS TP 5 Homo sapiens (Human)
Q61183 Papola
PAPOA_MOUSE
534 540 DSDNSMSVPSPTSAMKTSPL TP 5 Mus musculus (House mouse)
Q8K4N4 Mzf1
Q8K4N4_MOUSE
254 260 WHEEVGGIFSPGFTLQMDSI TP 3 Mus musculus (House mouse)
Q8K4N4 Mzf1
Q8K4N4_MOUSE
272 278 SITAEPDMMSPHLHVPWDLD TP 3 Mus musculus (House mouse)
Q8K4N4 Mzf1
Q8K4N4_MOUSE
292 298 MASLSGQIQSPTTEGGFAHA TP 3 Mus musculus (House mouse)
Q925J9 Med1
MED1_MOUSE
1439 1445 YGSPLISGSTPKHERGSPSH TP 4 Mus musculus (House mouse)
Q9ERG0 Lima1
LIMA1_MOUSE
689 695 DDNHVHAQQSPLEPEAPGWS TP 5 Mus musculus (House mouse)
Q9ERG0 Lima1
LIMA1_MOUSE
357 363 QQPMHPKPLSPDARTSSLPE TP 6 Mus musculus (House mouse)
Q9ERG0 Lima1
LIMA1_MOUSE
599 605 ASFRTSSIKSPKASSPSLRK TP 5 Mus musculus (House mouse)
Q9UIG0 BAZ1B
BAZ1B_HUMAN
155 161 EKKSDGACDSPSSDKENSSQ TP 4 Homo sapiens (Human)
P01106 MYC
MYC_HUMAN
68 74 SPSRRSGLCSPSYVAVTPFS TP 5 Homo sapiens (Human)
P34152-3 Ptk2
FAK1_MOUSE
907 913 GVKLQPQEISPPPTANLDRS TP 2 Mus musculus (House mouse)
Q00613 HSF1
HSF1_HUMAN
304 310 KEEPPSPPQSPRVEEASPGR TP 3 Homo sapiens (Human)
Q16665 HIF1A
HIF1A_HUMAN
638 644 MEDIKILIASPSPTHIHKET TP 4 Homo sapiens (Human)
P01106 MYC
MYC_HUMAN
59 65 FELLPTPPLSPSRRSGLCSP TP 5 Homo sapiens (Human)
1 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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