The Eukaryote Linear Motif resource for Functional Sites in Proteins
Functional site class:
MAPK Phosphorylation Site
Functional site description:
Site at which MAP Kinase phosphorylates substrates.
ELM with this model: MOD_ProDKin_1 
Description:
(S/T)P site at which Pro-directed kinases such as P38 MAP Kinase phosphorylate a Ser/Thr residue in various signal transduction pathways. These kinases require a docking motif to be activated, so the site is not meaningful by itself. MAP Kinase homologues are found widely in eukaryotes, including protozoa, but experimental data is from higher eukaryotes, mainly metazoa.
Pattern: ...([ST])P..
Pattern Probability: 0.0154332
Present in taxons: Drosophila melanogaster Eukaryota Vertebrata
Interaction Domain:
Pkinase (PF00069) Protein kinase domain (Stochiometry: 1 : 1)
o See 36 Instances for MOD_ProDKin_1
o Abstract
Proline-directed kinases phosphorylate a Ser/Thr residue preceding a Pro residue. This low specificity site is recognised by a large family of MAP and CDK-like kinases. However, the kinases achieve their target substrate specificity through separate docking motifs, which are also required to activate the kinase enzymatic function. A docking motif should be present in a candidate substrate sequence - or any (S/T)P motif is unlikely to be meaningful. For example, the P38 MAP kinase is activated by motifs approximating to [RK]XXXX#X# where # is a hydrophobic residue (Chang,2002) and ERK kinase is also activated by FxFP-like motifs (Fantz,2001).
o 5 GO-Terms:

o 36 Instances for MOD_ProDKin_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
RARA_HUMAN RARA 178 184 PECSESYTLTPEVGELIEKV TP 4 Homo sapiens (Human)
RARA_HUMAN RARA 442 448 GLAPPPGSCSPSLSPSSNRS TP 4 Homo sapiens (Human)
ELK4_HUMAN ELK4 378 384 SSIHFWSTLSPVAPLSPARL TP 4 Homo sapiens (Human)
JDP2_MOUSE Jdp2 145 151 CIVRTDSVRTPESEGNPLLE TP 3 Mus musculus (House mouse)
ETV6_HUMAN ETV6 254 260 SSESHPKPSSPRQESTRVIQ TP 3 Homo sapiens (Human)
K2C8_HUMAN KRT8 71 77 AVTVNQSLLSPLVLEVDPNI TP 5 Homo sapiens (Human)
TAL1_HUMAN TAL1 119 125 PGDGRMVQLSPPALAAPAAP TP 3 Homo sapiens (Human)
A6P3E3_MOUSE Ncoa2 733 739 EVTVKQEPASPKKKENALLR TP 4 Mus musculus (House mouse)
LCK_MOUSE Lck 56 62 TYEGSLPPASPLQDNLVIAL TP 7 Mus musculus (House mouse)
SP1_HUMAN SP1 736 742 AGSEGSGTATPSALITTNMV TP 4 Homo sapiens (Human)
PAX6_DANRE pax6a 410 416 SGTTSTGLISPGVSVPVQVP TP 4 Danio rerio (Zebrafish)
ELK4_HUMAN ELK4 384 390 STLSPVAPLSPARLQGANTL TP 4 Homo sapiens (Human)
SP1_HUMAN SP1 450 456 PNSGPIIIRTPTVGPNGQVS TP 4 Homo sapiens (Human)
TOB1_HUMAN TOB1 151 157 PASSVSSSPSPPFGHSAAVS TP 4 Homo sapiens (Human)
FAK1_HUMAN PTK2 907 913 GVKLQPQEISPPPTANLDRS TP 4 Homo sapiens (Human)
SOS1_HUMAN SOS1 1164 1170 RPESAPAESSPSKIMSKHLD TP 4 Homo sapiens (Human)
SOS1_HUMAN SOS1 1175 1181 SKIMSKHLDSPPAIPPRQPT TP 4 Homo sapiens (Human)
SOS1_HUMAN SOS1 1190 1196 PRQPTSKAYSPRYSISDRTS TP 4 Homo sapiens (Human)
GRB10_HUMAN GRB10 147 153 PFPELCGPGSPPVLTPGSLP TP 4 Homo sapiens (Human)
GRB10_HUMAN GRB10 473 479 TRMNILGSQSPLHPSTLSTV TP 4 Homo sapiens (Human)
NFAC4_HUMAN NFATC4 165 171 GGQGGGAFFSPSPGSSSLSS TP 5 Homo sapiens (Human)
NFAC4_HUMAN NFATC4 167 173 QGGGAFFSPSPGSSSLSSWS TP 5 Homo sapiens (Human)
PAPOA_MOUSE Papola 534 540 DSDNSMSVPSPTSAMKTSPL TP 5 Mus musculus (House mouse)
Q8K4N4_MOUSE Mzf1 254 260 WHEEVGGIFSPGFTLQMDSI TP 3 Mus musculus (House mouse)
Q8K4N4_MOUSE Mzf1 272 278 SITAEPDMMSPHLHVPWDLD TP 3 Mus musculus (House mouse)
Q8K4N4_MOUSE Mzf1 292 298 MASLSGQIQSPTTEGGFAHA TP 3 Mus musculus (House mouse)
MED1_MOUSE Med1 1439 1445 YGSPLISGSTPKHERGSPSH TP 4 Mus musculus (House mouse)
LIMA1_MOUSE Lima1 689 695 DDNHVHAQQSPLEPEAPGWS TP 5 Mus musculus (House mouse)
LIMA1_MOUSE Lima1 357 363 QQPMHPKPLSPDARTSSLPE TP 6 Mus musculus (House mouse)
LIMA1_MOUSE Lima1 599 605 ASFRTSSIKSPKASSPSLRK TP 5 Mus musculus (House mouse)
BAZ1B_HUMAN BAZ1B 155 161 EKKSDGACDSPSSDKENSSQ TP 4 Homo sapiens (Human)
MYC_HUMAN MYC 68 74 SPSRRSGLCSPSYVAVTPFS TP 5 Homo sapiens (Human)
FAK1_MOUSE Ptk2 907 913 GVKLQPQEISPPPTANLDRS TP 2 Mus musculus (House mouse)
HSF1_HUMAN HSF1 304 310 KEEPPSPPQSPRVEEASPGR TP 3 Homo sapiens (Human)
HIF1A_HUMAN HIF1A 638 644 MEDIKILIASPSPTHIHKET TP 4 Homo sapiens (Human)
MYC_HUMAN MYC 59 65 FELLPTPPLSPSRRSGLCSP TP 5 Homo sapiens (Human)
1 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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