The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
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MOD_SPalmitoyl_2

Accession:
Functional site class:
S-palmitoylation site
Functional site description:
Reversible addition of palmitate or other long chain fatty acids to protein at cysteine residues via a thioester linkage.
ELMs with same func. site: MOD_SPalmitoyl_2  MOD_SPalmitoyl_4 
ELM Description:
Class 2 Palmitoylation motif. Proteins that belong to this class: Ras proteins (H-Ras, N-Ras).
Pattern: G(C)M[GS][CL][KP]C
Pattern Probability: 3.052e-10
Present in taxons: Eukaryota Homo sapiens
Interaction Domain:
zf-DHHC (PF01529) DHHC zinc finger domain (Stochiometry: 1 : 1)
o See 2 Instances for MOD_SPalmitoyl_2
o Abstract
The post-translational addition of palmitate to many integral and peripheral membrane proteins is the most common modification. The palmitate group promotes stable membrane association. In combination with a myristoyl or farnesyl group, palmitoylation essentially permanently anchors a protein to the membrane. The target proteins of Palmitoyl acyltransferase (PAT) can be divided in four classes: (1) transmembrane proteins, (2) prenylated proteins, (3) exclusively palmitoylated proteins, and (4) myristoylated proteins.
o 4 selected references:

o 3 GO-Terms:

o 2 Instances for MOD_SPalmitoyl_2
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P01111 NRAS
RASN_HUMAN 		180 186 KLNSSDDGTQGCMGLPCVVM TP 1 Homo sapiens (Human)
P01112 HRAS
RASH_HUMAN 		180 186 KLNPPDESGPGCMSCKCVLS TP 1 Homo sapiens (Human)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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