The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
PKA Phosphorylation site
Functional site description:
Motifs phosphorylated by a subset of AGC group kinases including PKA that all have similar sequence specificity.
ELMs with same func. site: MOD_PKA_1  MOD_PKA_2 
ELM Description:
Secondary preference for PKA-type AGC kinase phosphorylation with a single Arg at p-2. This motif is probably more often targeted by other basophilic kinases of the AGC group, including PAK1 and PKC isoforms: These kinases actually show a stronger preference at p-2 than PKA, which has the strongest basophilic preference at p-3. AGC group kinases do not tolerate Pro at position +1. It is likely that some specificity determinants distinguishing among these kinases may be present at the less conserved non-basic sites.
Pattern: .R.([ST])[^P]..
Pattern Probability: 0.0094575
Present in taxon: Eukaryota
Interaction Domain:
Pkinase (PF00069) Protein kinase domain (Stochiometry: 1 : 1)
o See 28 Instances for MOD_PKA_2
o Abstract
PKA belongs to the large set of related AGC kinases having a preference for phosphorylating basophilic sites. cAMP-dependent protein kinase A (PKA) is the major target for cAMP action in eukaryotic cells. The enzyme is allosterically activated by binding of cAMP to two regulatory (R) subunits, which induces dissociation of two catalytic (C) subunits. The active kinase is then free to phosphorylate substrates on serine, or less commonly threonine residues in recognition motifs. The enzyme acts on a wide number of proteins involved in several biochemical processes. These include glucose metabolism (via activation and inactivation of glycogen phosphorylase b and glycogen synthase, respectively), fatty acid synthesis (via acetyl-coA carboxylase), and pyruvate oxidation (via pyruvate dehyrogenase complex). This is therefore a vital signaling enzyme in a number of metabolic processes, affecting many cell functions by activating or inactivating substrate proteins in the presence of cAMP.
o 4 selected references:

o 4 GO-Terms:

o 28 Instances for MOD_PKA_2
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P15389 Scn5a
SCN5A_RAT
523 529 SRTSMRPRSSRGSIFTFRRR TP 6 Rattus norvegicus (Norway rat)
Q62915 Cask
CSKP_RAT
559 565 QKMLREMRGSITFKIVPSYR TP 4 Rattus norvegicus (Norway rat)
P15389 Scn5a
SCN5A_RAT
526 532 SMRPRSSRGSIFTFRRRDQG TP 6 Rattus norvegicus (Norway rat)
P24155 Thop1
THOP1_RAT
641 647 PKVGMDYRTSILRPGGSEDA TP 6 Rattus norvegicus (Norway rat)
Q86UR1 NOXA1
NOXA1_HUMAN
458 464 FVVPAGPRMSGAPGRLPRSQ TP 3 Homo sapiens (Human)
Q38898 AKT2
AKT2_ARATH
207 213 TRLEKDIRYSYFWIRCFRLL TP 1 Arabidopsis thaliana (Thale cress)
O35274 Ppp1r9b
NEB2_RAT
91 97 RASDRGVRLSLPRASSLNEN TP 5 Rattus norvegicus (Norway rat)
Q38898 AKT2
AKT2_ARATH
326 332 TRRTMEFRNSIEAASNFVNR TP 1 Arabidopsis thaliana (Thale cress)
P48048 KCNJ1
IRK1_HUMAN
310 316 TSATCQVRTSYVPEEVLWGY TP 4 Homo sapiens (Human)
Q8IZL8 PELP1
PELP1_HUMAN
412 418 LNSWSIGRDSLSPGQERPYS TP 5 Homo sapiens (Human)
O35274 Ppp1r9b
NEB2_RAT
174 180 RRLLRQERASLQDRKLDVVV TP 4 Rattus norvegicus (Norway rat)
P60192 Snapin
SNAPN_RAT
47 53 DSHVHAVRESQVELREQIDN TP 6 Rattus norvegicus (Norway rat)
B9EIS4 GRK1
B9EIS4_HUMAN
18 24 NSAFIAARGSFDGSSSQPSR TP 4 Homo sapiens (Human)
Q26658 Stage specifi
Q26658_STRPU
84 90 DCKRCKARGSEKRMGPGDQR TP 6 Strongylocentrotus purpuratus (Purple sea urchin)
Q9UJY1 HSPB8
HSPB8_HUMAN
54 60 WPDWALPRLSSAWPGTLRSG TP 2 Homo sapiens (Human)
O15392 BIRC5
BIRC5_HUMAN
17 23 QPFLKDHRISTFKNWPFLEG TP 4 Homo sapiens (Human)
P52565 ARHGDIA
GDIR1_HUMAN
171 177 APKGMLARGSYSIKSRFTDD TP 4 Homo sapiens (Human)
P48048 KCNJ1
IRK1_HUMAN
216 222 LIRVANLRKSLLIGSHIYGK TP 4 Homo sapiens (Human)
P70531 Eef2k
EF2K_RAT
496 502 PSRLHLPRPSAVALEVQRLN TP 4 Rattus norvegicus (Norway rat)
P19793 RXRA
RXRA_HUMAN
24 30 SLTSPTGRGSMAAPSLHPSL TP 3 Homo sapiens (Human)
Q63943 Mef2d
MEF2D_MOUSE
187 193 PQQPALQRNSVSPGLPQRPA TP 6 Mus musculus (House mouse)
P33076 CIITA
C2TA_HUMAN
831 837 VVQELPGRLSFLGTRLTPPD TP 5 Homo sapiens (Human)
P33076 CIITA
C2TA_HUMAN
1047 1053 SLAASLLRLSLYNNCICDVG TP 5 Homo sapiens (Human)
P13796 LCP1
PLSL_HUMAN
2 8 MARGSVSDEEMMELREAFAK TP 6 Homo sapiens (Human)
O08852 Pkd1
PKD1_MOUSE
4156 4162 PLPSRSSRGSKSSPVVLPPS TP 3 Mus musculus (House mouse)
O88602 Cacng2
CCG2_MOUSE
317 323 QKDSKDSLHANTANRRTTPV TP 3 Mus musculus (House mouse)
O95644 NFATC1
NFAC1_HUMAN
242 248 HSPSTSPRASVTEESWLGAR TP 5 Homo sapiens (Human)
O95644 NFATC1
NFAC1_HUMAN
291 297 PSPHGSPRVSVTDDSWLGNT TP 5 Homo sapiens (Human)
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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