The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001426 P48048 KCNJ1
IRK1_HUMAN
216 222 LIRVANLRKSLLIGSHIYGK TP --- Homo sapiens (Human) 391

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0074 mutation analysis in vivo/in vitro Xu,1996 support certain FeatureDetection
experimental MI:0424 protein kinase assay in vitro Xu,1996 support likely InteractionDetection
experimental MI:0424 protein kinase assay in vivo Xu,1996 support certain InteractionDetection

o  Pathways

The sequence P48048 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)

o  Diseases

  • Sequence Variation VAR_019726 (Pos 219) has been implicated in Bartter Syndrome, Antenatal, Type 2 (OMIM:241200).
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org