The Eukaryote Linear Motif resource for Functional Sites in Proteins
Functional site class:
SH3 ligand
Functional site description:
This motif is involved in protein-protein interaction mediated by SH3 domains.
ELMs with same func. site: LIG_SH3_1  LIG_SH3_2  LIG_SH3_3  LIG_SH3_4  LIG_SH3_5 
ELM Description:
This is the motif recognized by those SH3 domains with a non-canonical class I recognition specificity
Pattern: ...[PV]..P
Pattern Probability: 0.0131729
Present in taxons: Bos taurus Metazoa
Interaction Domain:
SH3_1 (PF00018) SH3 domain (Stochiometry: 1 : 1)
PDB Structure: 2GBQ
<a href="" title="" target="_blank"><img src="/media/pdb.ico.png"/>2GBQ</a>
o See 16 Instances for LIG_SH3_3
o Abstract
SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. Ligand orientation depends on the position of the positive residue in the target peptide. Peptides that bind in a type I orientation contain the consensus R/KXXPXXP, while the type II orientation conform to the PXXPXR/K consensus.
o 10 GO-Terms:

o 16 Instances for LIG_SH3_3
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
P73_HUMAN TP73 407 413 HLQPPSYGPVLSPMNKVHGG TP 1 Homo sapiens (Human)
WASF1_MOUSE Wasf1 319 325 AGRTPVFVSPTPPPPPPPLP TP 1 Mus musculus (House mouse)
LAS17_YEAST LAS17 216 222 TASAPTTPAPALPPASPEVR TP 2 Saccharomyces cerevisiae (Baker"s yeast)
SOS1_MOUSE Sos1 1135 1141 GTDEVPVPPPVPPRRRPESA TP 1 Mus musculus (House mouse)
CY24A_TURTR CYBA 154 160 IKQPPSNPPPRPPAEARKKP TP 1 Tursiops truncatus (Bottlenosed dolphin)
CY24A_TURTR CYBA 149 155 QVGGTIKQPPSNPPPRPPAE TP 1 Tursiops truncatus (Bottlenosed dolphin)
CY24A_TURTR CYBA 153 159 TIKQPPSNPPPRPPAEARKK TP 1 Tursiops truncatus (Bottlenosed dolphin)
ORF3_HEVBU ORF3 102 108 RPSAPPLPHVVDLPQLGPRR TP 3 Hepatitis E virus (strain Burma)
TIP_SHV24 135 141 DPGMPKPTLPPRPANLGASQ TP 1 Herpesvirus saimiri (strain 484-77)
NS1_I72A2 NS 161 167 AIVGEISPLPSFPGHTIEDV TP 4 Influenza A virus (A/Udorn/307/1972(H3N2))
CD2_HUMAN CD2 294 300 HRSQAPSHRPPPPGHRVQHQ TP 2 Homo sapiens (Human)
DAG1_HUMAN DAG1 888 894 KGSRPKNMTPYRSPPPYVPP TP 2 Homo sapiens (Human)
TIP_SHV24 132 138 ESWDPGMPKPTLPPRPANLG TP 1 Herpesvirus saimiri (strain 484-77)
ORF3_HEVBU ORF3 93 99 HSAPLGVTRPSAPPLPHVVD TP 3 Hepatitis E virus (strain Burma)
BIN1_HUMAN BIN1 308 314 SQLRKGPPVPPPPKHTPSKE TP 6 Homo sapiens (Human)
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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