The Eukaryote Linear Motif resource for Functional Sites in Proteins
LIG_SH3_3 155
 
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Functional site class: SH3 ligand
Functional site description: This motif is involved in protein-protein interaction mediated by SH3 domains
ELMs: LIG_SH3_1 LIG_SH3_2 LIG_SH3_3 LIG_SH3_4 LIG_SH3_5
Description: This is the motif recognized by those SH3 domains with a non-canonical class I recognition specificity
Pattern: ...[PV]..P (Probability: 0.0131729)
Present in taxons: Bos taurus Metazoa
PDB Structure: 2GBQ
<img src="/media/pdb.ico.png"/><a href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2GBQ" target="_blank">2GBQ</a>
Interaction Domain:

SH3_1 (PF00018)
SH3 domain
(Stochiometry: 1 : 1)

o See 15 Instances for LIG_SH3_3


o Abstract

SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. Ligand orientation depends on the position of the positive residue in the target peptide. Peptides that bind in a type I orientation contain the consensus R/KXXPXXP, while the type II orientation conform to the PXXPXR/K consensus

o 10 GO-Terms:

o 15 Instances for LIG_SH3_3
(click table headers for sorting)
SequenceStartEndSubsequence
Instance LogicPDB Organism
P73_HUMAN 407 413 HLQPPSYGPVLSPMNKVHGG true positive --- Homo sapiens (Human)
WASF1_MOUSE 319 325 AGRTPVFVSPTPPPPPPPLP true positive --- Mus musculus (House mouse)
LAS17_YEAST 216 222 TASAPTTPAPALPPASPEVR true positive --- Saccharomyces cerevisiae (Baker"s yeast)
SOS1_MOUSE 1135 1141 GTDEVPVPPPVPPRRRPESA true positive 2GBQ
 Mus musculus (House mouse)
CY24A_TURTR 154 160 IKQPPSNPPPRPPAEARKKP true positive --- Tursiops truncatus (Bottlenosed dolphin)
CY24A_TURTR 149 155 QVGGTIKQPPSNPPPRPPAE true positive --- Tursiops truncatus (Bottlenosed dolphin)
CY24A_TURTR 153 159 TIKQPPSNPPPRPPAEARKK true positive --- Tursiops truncatus (Bottlenosed dolphin)
ORF3_HEVBU 102 108 RPSAPPLPHVVDLPQLGPRR true positive --- Hepatitis E virus (strain Burma)
TIP_SHV24 135 141 DPGMPKPTLPPRPANLGASQ true positive --- Herpesvirus saimiri (strain 484-77)
NS1_I72A2 161 167 AIVGEISPLPSFPGHTIEDV true positive --- Influenza A virus (A/Udorn/307/1972(H3N2))
CD2_HUMAN 294 300 HRSQAPSHRPPPPGHRVQHQ true positive --- Homo sapiens (Human)
DAG1_HUMAN 888 894 KGSRPKNMTPYRSPPPYVPP true positive --- Homo sapiens (Human)
TIP_SHV24 132 138 ESWDPGMPKPTLPPRPANLG true positive --- Herpesvirus saimiri (strain 484-77)
ORF3_HEVBU 93 99 HSAPLGVTRPSAPPLPHVVD true positive --- Hepatitis E virus (strain Burma)
BIN1_HUMAN 308 314 SQLRKGPPVPPPPKHTPSKE true positive --- Homo sapiens (Human)

Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)

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