Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI002443 | O00499-6 BIN1 BIN1_HUMAN |
308 | 314 | SQLRKGPPVPPPPKHTPSKE | TP | --- | Homo sapiens (Human) | 482 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0017 | classical fluorescence spectroscopy | in vitro | Pineda-Lucena,2005 | support | certain | InteractionDetection |
experimental | MI:0018 | two hybrid | in vivo | Pineda-Lucena,2005 | support | certain | InteractionDetection |
experimental | MI:0077 | nuclear magnetic resonance | in vitro | Pineda-Lucena,2005 | support | certain | InteractionDetection FeatureDetection |
experimental | MI:0405 | competition binding | in vitro | Pineda-Lucena,2005 | support | certain | InteractionDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Pineda-Lucena,2005 | support | certain | FeatureDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000324:
An intramolecular interaction of an SH3 binding motif, encoded by exon 12A, in Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1) with the SH3 domain of Bin1 prevents interaction of the Bin1 SH3 domain with the SH3 binding motif of Myc proto-oncogene protein (MYC).
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement