LIG_SH3_3
Accession: | |
---|---|
Functional site class: | SH3 ligand |
Functional site description: | This motif is involved in protein-protein interaction mediated by SH3 domains. |
ELMs with same func. site: | LIG_SH3_1 LIG_SH3_2 LIG_SH3_3 LIG_SH3_4 LIG_SH3_5 |
ELM Description: | This is the motif recognized by those SH3 domains with a non-canonical class I recognition specificity |
Pattern: | ...[PV]..P |
Pattern Probability: | 0.0131729 |
Present in taxons: | Bos taurus Metazoa |
Interaction Domain: |
SH3_1 (PF00018)
SH3 domain
(Stochiometry: 1 : 1)
|
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SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. Ligand orientation depends on the position of the positive residue in the target peptide. Peptides that bind in a type I orientation contain the consensus R/KXXPXXP, while the type II orientation conform to the PXXPXR/K consensus. |


(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement