ELM Details - LIG_SH3

LIG_SH3_3

Functional site class:	SH3 ligand
Functional site description:	This motif is involved in protein-protein interaction mediated by SH3 domains
ELM(s):	LIG_SH3_3, LIG_SH3_4, LIG_SH3_1, LIG_SH3_2, LIG_SH3_5
LIG_SH3_3 description:	This is the motif recognized by those SH3 domains with a non-canonical class I recognition specificity
Pattern:	...[PV]..P
Present in taxon(s):	Metazoa Bos taurus
Not represented in taxon(s):

See instances for LIG_SH3_3

Abstract

SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. Ligand orientation depends on the position of the positive residue in the target peptide. Peptides that bind in a type I orientation contain the consensus R/KXXPXXP, while the type II orientation conform to the PXXPXR/K consensus

Selected references

This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.

Biological Process

  cell growth and/or maintenance

GO:0008150

  cell communication

GO:0007154

  signal transduction

GO:0007165

Cellular Component

  plasma membrane

GO:0005886

  focal adhesion

GO:0005925

  cytosol

GO:0005829

Molecular Function

  Binding

GO:0005488

  protein binding

GO:0005515

  protein domain specific binding

GO:0019904

  SH3-domain binding

GO:0017124

Instances for LIG_SH3_3

Sequence	Position	Subsequence (Click for evidence information)	PDB	Gene Name	Protein Description	Organism
P73_HUMAN	407-413	LQPPSYGPVLSPMNKVHG	-	Name=TP73; Synonyms=P73;	Tumor protein p73 (p53-like transcription factor) (p53-related protein).	Homo sapiens (Human).
CY24A_TURTR	148-154	VGGTIKQPPSNPPPRPPA	-	Name=CYBA;	Cytochrome b-245 light chain (p22 phagocyte B-cytochrome) (Neutrophil cytochrome b 22 kDa polypeptide) (p22-phox) (p22phox) (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Superoxide- generating NADPH oxidase light chain subunit).	Tursiops truncatus (Atlantic bottle-nosed dolphin).
CY24A_TURTR	152-158	IKQPPSNPPPRPPAEARK	-	Name=CYBA;	Cytochrome b-245 light chain (p22 phagocyte B-cytochrome) (Neutrophil cytochrome b 22 kDa polypeptide) (p22-phox) (p22phox) (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Superoxide- generating NADPH oxidase light chain subunit).	Tursiops truncatus (Atlantic bottle-nosed dolphin).
CY24A_TURTR	153-159	KQPPSNPPPRPPAEARKK	-	Name=CYBA;	Cytochrome b-245 light chain (p22 phagocyte B-cytochrome) (Neutrophil cytochrome b 22 kDa polypeptide) (p22-phox) (p22phox) (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Superoxide- generating NADPH oxidase light chain subunit).	Tursiops truncatus (Atlantic bottle-nosed dolphin).
LAS17_YEAST	216-222	ASAPTTPAPALPPASPEV	-	Name=LAS17; OrderedLocusNames=YOR181W;	Proline-rich protein LAS17.	Saccharomyces cerevisiae (Baker's yeast).
SOS1_MOUSE	1135-1141	TDEVPVPPPVPPRRRPES	2GBQ	Name=Sos1;	Son of sevenless homolog 1 (SOS-1) (mSOS-1).	Mus musculus (Mouse).
WASF1_MOUSE	319-325	GRTPVFVSPTPPPPPPPL	-	Name=Wasf1; Synonyms=Wave1;	Wiskott-Aldrich syndrome protein family member 1 (WASP family protein member 1) (Protein WAVE-1).	Mus musculus (Mouse).