LIG_SH3_3
| Accession: | |
|---|---|
| Functional site class: | SH3 ligand |
| Functional site description: | This motif is involved in protein-protein interaction mediated by SH3 domains. |
| ELMs with same func. site: | LIG_SH3_1 LIG_SH3_2 LIG_SH3_3 LIG_SH3_4 LIG_SH3_5 |
| ELM Description: | This is the motif recognized by those SH3 domains with a non-canonical class I recognition specificity |
| Pattern: | ...[PV]..P |
| Pattern Probability: | 0.0131729 |
| Present in taxons: | Bos taurus Metazoa |
| Interaction Domain: |
SH3_1 (PF00018)
SH3 domain
(Stochiometry: 1 : 1)
|
 Abstract |
SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. Ligand orientation depends on the position of the positive residue in the target peptide. Peptides that bind in a type I orientation contain the consensus R/KXXPXXP, while the type II orientation conform to the PXXPXR/K consensus. |
10 GO-Terms:
16 Instances for LIG_SH3_3
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement