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| Functional site class: | MAPK docking motif |
| Functional site description: | The docking interaction in the MAP kinase cascades is achieved through specific conserved regions on MAPKs (docking groove) and MAPK-interacting molecules (the MAPK docking motif). The docking motif is usually - but not always - the sequence of a substrate protein. |
|---|---|
| ELMs: | LIG_MAPK_1 LIG_MAPK_2 |
| Description: | MAPK interacting molecules (e.g. MAPKKs, substrates, phosphatases) carry docking motifs that help to regulate specific interactions in the MAPK cascade. The classic MAPK docking site was first identified in c-JUN, a substrate of JNK (Kallunki et al., 1996). This motif is characterized by a cluster of basic residues positioned upstream to a #-x-# motif. The substrates that carry this motif recognize a broad range of MAPKs (Sharrocks at al., 2000). |
| Pattern: | [KR]{0,2}[KR].{0,2}[KR].{2,4}[ILVM].[ILVF] (Probability: 0.0043238) |
| Present in taxons: |
Eukaryota
|
| Interaction Domain: |
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See 15 Instances for LIG_MAPK_1
|
| MAPK (Mitogen-activated protein kinase) signalling pathways are characterized by a cascade of multiple kinases that contribute to regulate a variety of extracellular stimuli, thereby to control the cellular environment. |
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Please cite: ELM - the database of eukaryotic linear motifs (PMID:
22110040)
ELM data can be downloaded and distributed for non-commercial use according to the ELM Software License Agreement





