 << LIG_SH2_STAT6 << |
Menu | >> LIG_SH3_2 >> |
| Functional site class: | SH3 ligand |
| Functional site description: | This motif is involved in protein-protein interaction mediated by SH3 domains |
|---|---|
| ELMs: | LIG_SH3_1 LIG_SH3_2 LIG_SH3_3 LIG_SH3_4 LIG_SH3_5 |
| Description: | This is the motif recognized by class I SH3 domains |
| Pattern: | [RKY]..P..P (Probability: 0.0012370) |
| Present in taxons: |
 Bos taurus
Gallus gallus
Homo sapiens
Mus musculus
Opisthokonta
Rattus norvegicus
Saccharomyces cerevisiae
|
| Interaction Domain: |
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| SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. Ligand orientation depends on the position of the positive residue in the target peptide. Peptides that bind in a type I orientation contain the consensus R/KXXPXXP, while the type II orientation conform to the PXXPXR/K consensus |
20 selected references:
10 GO-Terms:
5 Instances for LIG_SH3_1
(click table headers for sorting)
| Sequence | Start | End | Subsequence | Instance Logic | PDB | Organism |
|---|---|---|---|---|---|---|
 BTK_HUMAN |
186 | 192 | SHRKTKKPLPPTPEEDQILK | true positive | --- |
Homo sapiens
(Human)
|
|
BTK_HUMAN |
200 | 206 | EDQILKKPLPPEPAAAPVST | true positive | --- |
Homo sapiens
(Human)
|
|
RAD51_HUMAN |
315 | 321 | TRICKIYDSPCLPEAEAMFA | true positive | --- |
Homo sapiens
(Human)
|
|
P85A_HUMAN |
88 | 94 | ISPPTPKPRPPRPLPVAPGS | true positive | --- |
Homo sapiens
(Human)
|
|
TAU_HUMAN |
547 | 553 | KKVAVVRTPPKSPSSAKSRL | true positive | --- |
Homo sapiens
(Human)
|
Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)
ELM data can be downloaded and distributed for non-commercial use according to the ELM Software License Agreement