The Eukaryote Linear Motif resource for Functional Sites in Proteins
Functional site class:
SH3 ligand
Functional site description:
This motif is involved in protein-protein interaction mediated by SH3 domains.
ELMs with this model: LIG_SH3_1  LIG_SH3_2  LIG_SH3_3  LIG_SH3_4  LIG_SH3_5 
Description:
This is the motif recognized by class I SH3 domains
Pattern: [RKY]..P..P
Pattern Probability: 0.0012370
Present in taxons: Bos taurus Gallus gallus Homo sapiens Mus musculus Opisthokonta Rattus norvegicus Saccharomyces cerevisiae
Interaction Domain:
SH3_1 (PF00018) SH3 domain (Stochiometry: 1 : 1)
o See 5 Instances for LIG_SH3_1
o Abstract
SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. Ligand orientation depends on the position of the positive residue in the target peptide. Peptides that bind in a type I orientation contain the consensus R/KXXPXXP, while the type II orientation conform to the PXXPXR/K consensus.
o 20 selected references:

o 10 GO-Terms:

o 5 Instances for LIG_SH3_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
BTK_HUMAN BTK 186 192 SHRKTKKPLPPTPEEDQILK TP 1 Homo sapiens (Human)
BTK_HUMAN BTK 200 206 EDQILKKPLPPEPAAAPVST TP 1 Homo sapiens (Human)
RAD51_HUMAN RAD51 315 321 TRICKIYDSPCLPEAEAMFA TP 2 Homo sapiens (Human)
P85A_HUMAN PIK3R1 88 94 ISPPTPKPRPPRPLPVAPGS TP 2 Homo sapiens (Human)
TAU_HUMAN MAPT 547 553 KKVAVVRTPPKSPSSAKSRL TP 1 Homo sapiens (Human)
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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