The Eukaryote Linear Motif resource for Functional Sites in Proteins
LIG_SH3_1 5
 
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Functional site class: SH3 ligand
Functional site description: This motif is involved in protein-protein interaction mediated by SH3 domains
ELMs: LIG_SH3_1 LIG_SH3_2 LIG_SH3_3 LIG_SH3_4 LIG_SH3_5
Description: This is the motif recognized by class I SH3 domains
Pattern: [RKY]..P..P (Probability: 0.0012370)
Present in taxons: Bos taurus Fungi/Metazoa group Gallus gallus Homo sapiens Mus musculus Rattus norvegicus Saccharomyces cerevisiae
Interaction Domain:

SH3_1 (PF00018)
SH3 domain
(Stochiometry: 1 : 1)

o See 5 Instances for LIG_SH3_1


o Abstract

SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. Ligand orientation depends on the position of the positive residue in the target peptide. Peptides that bind in a type I orientation contain the consensus R/KXXPXXP, while the type II orientation conform to the PXXPXR/K consensus

o 20 selected references:

o 10 GO-Terms:

o 5 Instances for LIG_SH3_1
(click table headers for sorting)
SequenceStartEndSubsequence
Instance LogicPDB Organism
RAD51_HUMAN 315 321 TRICKIYDSPCLPEAEAMFA true positive --- Homo sapiens (Human)
BTK_HUMAN 186 192 SHRKTKKPLPPTPEEDQILK true positive --- Homo sapiens (Human)
BTK_HUMAN 200 206 EDQILKKPLPPEPAAAPVST true positive --- Homo sapiens (Human)
P85A_HUMAN 88 94 ISPPTPKPRPPRPLPVAPGS true positive --- Homo sapiens (Human)
TAU_HUMAN 547 553 KKVAVVRTPPKSPSSAKSRL true positive --- Homo sapiens (Human)