The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002041 P20963 CD247
69 86 QNQLYNELNLGRREEYDVLD TP --- Homo sapiens (Human) 164

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Sunder-Plassmann,1997 support likely InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Sunder-Plassmann,1997 support likely FeatureDetection
experimental MI:0405 competition binding in vitro Bu,1995 support likely InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P43405) KSYK_HUMAN PF00017 (SH2)
SH2 domain
15 92 [mitab][xml]
(P43405) KSYK_HUMAN PF00017 (SH2)
SH2 domain
168 244 [mitab][xml]
(P43403) ZAP70_HUMAN PF00017 (SH2)
SH2 domain
10 87 [mitab][xml]
(P43403) ZAP70_HUMAN PF00017 (SH2)
SH2 domain
163 239 [mitab][xml]

o  Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence P20963 is implicated in the following 8 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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