The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002040 P07766 CD3E
CD3E_HUMAN
185 202 PNPDYEPIRKGQRDLYSGLN TP 1A81  
pdb:1A81
Homo sapiens (Human) 207

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Bu,1995 support certain
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Kesti,2007 support certain
experimental MI:0074 mutation analysis in vivo/in vitro Bu,1995 support certain FeatureDetection
experimental MI:0107 surface plasmon resonance in vitro Bu,1995 support certain InteractionDetection FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Futterer,1998 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P43405) KSYK_HUMAN PF00017 (SH2)
SH2 domain
15 92 0.0214/0.0272 [mitab][xml]
(P43405) KSYK_HUMAN PF00017 (SH2)
SH2 domain
168 244 0.0214/0.0272 [mitab][xml]
(P43403) ZAP70_HUMAN PF00017 (SH2)
SH2 domain
10 87 [mitab][xml]
(P43403) ZAP70_HUMAN PF00017 (SH2)
SH2 domain
163 239 [mitab][xml]

o  Switches



This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence P07766 is implicated in the following 6 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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