LIG_WW_3
ELM server details
ELM
blue dot
Functional site class:
 WW ligand
Functional site description:
 the motif is implicated in protein-protein interactions mediated WW domains
ELM(s): LIG_WW_4, LIG_WW_1, LIG_WW_2, LIG_WW_3
LIG_WW_3 description: WW domain of group III binding motif
Pattern: .PPR.
Present in taxon(s): Homo sapiens  Eukaryota  Mus musculus  Rattus norvegicus  
Not represented in taxon(s):

o Abstract

WW are small modular domains of 38-40 residues long that mediate protein-protein interaction through binding of short proline rich regions within proteins. WW domain-containing proteins are involved in many cellular processes such as ubiquitin mediated protein degradation and mitotic regulation and they are also implicated directly or indirectly in several human diseases such as muscular distrophy and Alzheimer’s and Huntington’s diseases. Based on their ligand specificity, the WW domains can be devided in five class. Group I WW domains bind proteins containing the PPXY motif, while the group II recognizes the PPLP motif. Group IV recognition is serine-phosphorylation dependent.

o Selected references

Bedford MT, Sarbassova D, Xu J, Leder P, Yaffe MB
A novel pro-Arg motif recognized by WW domains.
J Biol Chem 2000 Apr 7;275(14) : 10359-69.
PMID: 10744724

Otte L, Wiedemann U, Schlegel B, Pires JR, Beyermann M, Schmieder P, Krause G, Volkmer-Engert R, Schneider-Mergener J, Oschkinat H
WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains.
Protein Sci 2003 Mar;12(3) : 491-500.
PMID: 12592019

o This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.

Biological Process
  cell growth and/or maintenance
  cell communication
  signal transduction
Cellular Component
  cytosol
Molecular Function
  Binding
  protein binding

 

o Instances for LIG_WW_3

No instances annotated