ELM detail for MOD

MOD_NMyristoyl 60


<< MOD_N-GLC_2 <<	Menu	>> MOD_OFUCOSY >>

Functional site class:	N-myristoylation site
Functional site description:	Myristate attached to an N-terminal glycine residue acts as a membrane anchor for some soluble cytoplasmic proteins
ELMs:	MOD_NMyristoyl
Description:	Generic motif for N-Myristoylation site.
Pattern:	`^M{0,1}(G)[^EDRKHPFYW]..[STAGCN][^P]` (Probability: 0.0000159)
Present in taxons:	Arabidopsis thaliana Dictyostelium discoideum Drosophila melanogaster Eukaryota Homo sapiens Mus musculus Plasmodium falciparum Schizosaccharomyces pombe
Interaction Domain:	NMT_C (PF02799) Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain (Stochiometry: 1 : 1)

See 48 Instances for MOD_NMyristoyl

Abstract

Myristoyl-CoA:protein N-myristoyltransferase (EC 2.3.1.97) (NMT) covalently transfers a myristate group to an N-terminal glycine residue. (The N-terminal methionine must therefore be cleaved away.) The attached lipid moiety can act as a membrane anchor. The Src oncoprotein is a well known example of an N-myristoylated protein.

Biological Process:
N-Terminal Peptidyl-Glycine N-Myristoylation	0018008
N-Terminal Protein Myristoylation	0006499
Protein Myristoylation	0018377
Cellular Compartment:
Anchored To Plasma Membrane	0046658
Cytosol	0005829
Molecular Function:
Glycyl-Peptide N-Tetradecanoyltransferase	0004379
Myristoyltransferase	0019107
Peptidyl-Lysine N6-Myristoyltransferase	0018030

8 GO-Terms:

48 Instances for MOD_NMyristoyl
(click table headers for sorting)

Sequence	Start	End	Subsequence	Instance Logic	PDB	Organism
SRC_HUMAN	1	7	MGSNKSKPKDASQRRRSLEP	true positive	---	Homo sapiens (Human)
GAG_HTL1A	1	7	MGQIFSRSASPIPRPPRGLA	true positive	---	Human T-cell lymphotrophic virus type 1 (strain ATK)
GAG_HV1H2	1	7	MGARASVLSGGELDRWEKIR	true positive	---	HIV-1 M:B_HXB2R
GAG_MMTVC	1	7	MGVSGSKGQKLFVSVLQRLL	true positive	---	Mouse mammary tumor virus (STRAIN C3H)
POLG_POL1M	1	7	MGAQVSSQKVGAHENSNRAY	true positive	---	Human poliovirus 1 Mahoney
PP220_ASFB7	1	7	MGNRGSSTSSRPPLSSEANL	true positive	---	African swine fever virus BA71V
MU1_REOVD	1	7	MGNASSIVQTINVTGDGNVF	true positive	---	Mammalian orthoreovirus 3 Dearing
E7R_VACCW	1	7	MGTAATIQTPTKLMNKENAE	true positive	---	Vaccinia virus WR
SRC_RSVSA	1	7	MGSSKSKPKDPSQRRCSLEP	true positive	---	Rous sarcoma virus (strain Schmidt-Ruppin A)
VG09_VACCC	1	7	MGGGVSVELPKRDPPPGVPT	true positive	---	Vaccinia virus Copenhagen
L1R_VACCC	1	7	MGAAASIQTTVNTLSERISS	true positive	---	Vaccinia virus Copenhagen
Z_LASSJ	1	7	MGNKQAKAPESKDSPRASLI	true positive	---	Lassa virus Josiah
RECO_BOVIN	1	7	MGNSKSGALSKEILEELQLN	true positive	1IKU 1JSA	Bos taurus (Cattle)
KAPCA_HUMAN	1	7	MGNAAAAKKGSEQESVKEFL	true positive	---	Homo sapiens (Human)
BASP1_RAT	1	7	MGSKLSKKKKGYNVNDEKAK	true positive	---	Rattus norvegicus (Norway rat)
PDE2A_HUMAN	1	7	MGQACGHSILCRSQQYPAAR	true positive	---	Homo sapiens (Human)
ZZEF1_HUMAN	1	7	MGNAPSHSSEDEAAAAGGEG	true positive	---	Homo sapiens (Human)
RFTN1_HUMAN	1	7	MGCGLNKLEKRDEKRPGNIY	true positive	---	Homo sapiens (Human)
CD5R1_HUMAN	1	7	MGTVLSLSPSYRKATLFEDG	true positive	---	Homo sapiens (Human)
XRP2_HUMAN	1	7	MGCFFSKRRKADKESRPENE	true positive	2BX6 3BH6 3BH7	Homo sapiens (Human)
DEGS1_RAT	1	7	MGNRVSREEFEWVYTDQPHA	true positive	---	Rattus norvegicus (Norway rat)
K1609_HUMAN	1	7	MGNSRSRVGRSFCSQFLPEE	true positive	---	Homo sapiens (Human)
EEPD1_HUMAN	1	7	MGSTLGCHRSIPRDPSDLSH	true positive	---	Homo sapiens (Human)
DYM_HUMAN	1	7	MGSNSSRIGDLPKNEYLKKL	true positive	---	Homo sapiens (Human)
KAPCA_BOVIN	1	7	MGNAAAAKKGSEQESVKEFL	true positive	1Q24 1Q8W 1SMH 1VEB 1XH4 1YDR 2C1A 2OH0 2VNW	Bos taurus (Cattle)
HCK_HUMAN	1	7	MGGRSSCEDPGCPRDEERAP	true positive	---	Homo sapiens (Human)
NOS3_BOVIN	1	7	MGNLKSVGQEPGPPCGLGLG	true positive	---	Bos taurus (Cattle)
MARCS_HUMAN	1	7	MGAQFSKTAAKGEAAAERPG	true positive	---	Homo sapiens (Human)
BTBD7_HUMAN	1	7	MGANASNYPHSCSPRVGGNS	true positive	---	Homo sapiens (Human)
GUC1B_BOVIN	1	7	MGQQFSWEEAEENGAVGAAD	true positive	1JBA	Bos taurus (Cattle)
TCAM2_HUMAN	1	7	MGIGKSKINSCPLSLSWGKR	true positive	---	Homo sapiens (Human)
ARL4C_HUMAN	1	7	MGNISSNISAFQSLHIVMLG	true positive	---	Homo sapiens (Human)
GNAI1_HUMAN	1	7	MGCTLSAEDKAAVERSKMID	true positive	2EBC	Homo sapiens (Human)
CCNY_HUMAN	1	7	MGNTTSCCVSSSPKLRRNAH	true positive	---	Homo sapiens (Human)
CANB1_HUMAN	1	7	MGNEASYPLEMCSHFDADEI	true positive	1AUI 1M63 1MF8	Homo sapiens (Human)
ARF1_HUMAN	1	7	MGNIFANLFKGLFGKKEMRI	true positive	1HUR	Homo sapiens (Human)
RN125_HUMAN	1	7	MGSVLSTDSGKSAPASATAR	true positive	---	Homo sapiens (Human)
AKIB1_HUMAN	1	7	MGNTTTKFRKALINGDENLA	true positive	---	Homo sapiens (Human)
RN157_HUMAN	1	7	MGALTSRQHAGVEEVDIPSN	true positive	---	Homo sapiens (Human)
FMNL2_HUMAN	1	7	MGNAGSMDSQQTDFRAHNVP	true positive	---	Homo sapiens (Human)
PI3R4_HUMAN	1	7	MGNQLAGIAPSQILSVESYF	true positive	---	Homo sapiens (Human)
AIFM2_HUMAN	1	7	MGSQVSVESGALHVVIVGGG	true positive	---	Homo sapiens (Human)
LNP_HUMAN	1	7	MGGLFSRWRTKPSTVEVLES	true positive	---	Homo sapiens (Human)
SLAP2_HUMAN	1	7	MGSLPSRRKSLPSPSLSSSV	true positive	---	Homo sapiens (Human)
ANM8_HUMAN	1	7	MGMKHSSRCLLLRRKMAENA	true positive	---	Homo sapiens (Human)
SERC1_HUMAN	1	7	MGSVLGLCSMASWIPCLCGS	true positive	---	Homo sapiens (Human)
PALD_HUMAN	1	7	MGTTASTAQQTVSAGTPFEG	true positive	---	Homo sapiens (Human)
HBSAG_HBVD3	1	7	MGQNLSTSNPLGFFPDHQLD	true positive	---	Hepatitis B virus ayw/France/Tiollais/1979

Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)

ELM data can be downloaded and distributed for non-commercial use according to the ELM Software License Agreement

feedback@elm.eu.org