ELM - instance MOD_NMyristoyl in sequence O00408 at position 1

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002310	O00408 PDE2A PDE2A_HUMAN	1	7	MGQACGHSILCRSQQYPAAR	TP	---	Homo sapiens (Human)	941

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0943	detection by mass spectrometry	in vivo/in vitro	Suzuki,2010	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000491:

Alternative splicing removes the myristoylation motif of cGMP-dependent 3\',5\'-cyclic phosphodiesterase (PDE2A). The soluble Isoform PDE2A1 is expressed in a variety of peripheral tissues, whereas the membrane-associated Isoform PDE2A3 is found exclusively in the brain. Isoform PDE2A3 requires N-myristoylation together with palmitoylation to be targeted to synapses, allowing control and crosstalk of cyclic nucleotides.

Pathways

KEGG: The sequence O00408 is implicated in the following 6 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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