The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Accession:
Functional site class:
N-myristoylation site
Functional site description:
Myristate attached to an N-terminal glycine residue acts as a membrane anchor for some soluble cytoplasmic proteins.
ELM Description:
Generic motif for N-Myristoylation site.
Pattern: ^M{0,1}(G)[^EDRKHPFYW]..[STAGCN][^P]
Pattern Probability: 0.0000250
Present in taxons: Arabidopsis thaliana Dictyostelium discoideum Drosophila melanogaster Eukaryota Homo sapiens Mus musculus Plasmodium falciparum Schizosaccharomyces pombe
Interaction Domain:
NMT_C (PF02799) Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain (Stochiometry: 1 : 1)
PDB Structure: 1AUI
o See 48 Instances for MOD_NMyristoyl
o Abstract
Myristoyl-CoA:protein N-myristoyltransferase (EC 2.3.1.97) (NMT) covalently transfers a myristate group to an N-terminal glycine residue. The N-terminal methionine must therefore be cleaved away. The attached lipid moiety can act as a membrane anchor. The Src oncoprotein is a well known example of an N-myristoylated protein.
o 8 GO-Terms:

o 48 Instances for MOD_NMyristoyl
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
O73557 Z
Z_LASSJ
1 7 MGNKQAKAPESKDSPRASLI TP 2 Lassa virus Josiah
P20540 L1R
L1R_VACCC
1 7 MGAAASIQTTVNTLSERISS TP 2 Vaccinia virus Copenhagen
P21030 G9R
VG09_VACCC
1 7 MGGGVSVELPKRDPPPGVPT TP 2 Vaccinia virus Copenhagen
P68446 VACWR063
E7R_VACCW
1 7 MGTAATIQTPTKLMNKENAE TP 2 Vaccinia virus WR
P00524 V-SRC
SRC_RSVSA
1 7 MGSSKSKPKDPSQRRCSLEP TP 3 Rous sarcoma virus (strain Schmidt-Ruppin A)
P11078 M2
MU1_REOVD
1 7 MGNASSIVQTINVTGDGNVF TP 1 Mammalian orthoreovirus 3 Dearing
Q08358 Ba71V-92
PP220_ASFB7
1 7 MGNRGSSTSSRPPLSSEANL TP 1 African swine fever virus BA71V
P03300 
POLG_POL1M
1 7 MGAQVSSQKVGAHENSNRAY TP 1 Human poliovirus 1 Mahoney
P03138 S
HBSAG_HBVD3
1 7 MGQNLSTSNPLGFFPDHQLD TP 1 Hepatitis B virus ayw/France/Tiollais/1979
P11284 gag
GAG_MMTVC
1 7 MGVSGSKGQKLFVSVLQRLL TP 1 Mouse mammary tumor virus (STRAIN C3H)
P04591 gag
GAG_HV1H2
1 7 MGARASVLSGGELDRWEKIR TP 1 HIV-1 M:B_HXB2R
P03345 gag
GAG_HTL1A
1 7 MGQIFSRSASPIPRPPRGLA TP 2 Human T-cell lymphotrophic virus type 1 (strain ATK)
Q9ULE6 PALD1
PALD_HUMAN
1 7 MGTTASTAQQTVSAGTPFEG TP 1 Homo sapiens (Human)
Q9P2G1 ANKIB1
AKIB1_HUMAN
1 7 MGNTTTKFRKALINGDENLA TP 1 Homo sapiens (Human)
Q9P203 BTBD7
BTBD7_HUMAN
1 7 MGANASNYPHSCSPRVGGNS TP 1 Homo sapiens (Human)
Q9NRX5 SERINC1
SERC1_HUMAN
1 7 MGSVLGLCSMASWIPCLCGS TP 1 Homo sapiens (Human)
Q9NR22 PRMT8
ANM8_HUMAN
1 7 MGMKHSSRCLLLRRKMAENA TP 3 Homo sapiens (Human)
Q9H6Q3 SLA2
SLAP2_HUMAN
1 7 MGSLPSRRKSLPSPSLSSSV TP 3 Homo sapiens (Human)
Q9C0E8 LNP
LNP_HUMAN
1 7 MGGLFSRWRTKPSTVEVLES TP 1 Homo sapiens (Human)
Q9BRQ8 AIFM2
AIFM2_HUMAN
1 7 MGSQVSVESGALHVVIVGGG TP 1 Homo sapiens (Human)
Q99570 PIK3R4
PI3R4_HUMAN
1 7 MGNQLAGIAPSQILSVESYF TP 1 Homo sapiens (Human)
Q96PY5 FMNL2
FMNL2_HUMAN
1 7 MGNAGSMDSQQTDFRAHNVP TP 1 Homo sapiens (Human)
Q96PX1 RNF157
RN157_HUMAN
1 7 MGALTSRQHAGVEEVDIPSN TP 1 Homo sapiens (Human)
Q96EQ8 RNF125
RN125_HUMAN
1 7 MGSVLSTDSGKSAPASATAR TP 2 Homo sapiens (Human)
Q8ND76 CCNY
CCNY_HUMAN
1 7 MGNTTSCCVSSSPKLRRNAH TP 6 Homo sapiens (Human)
Q86XR7 TICAM2
TCAM2_HUMAN
1 7 MGIGKSKINSCPLSLSWGKR TP 8 Homo sapiens (Human)
Q7RTS9 DYM
DYM_HUMAN
1 7 MGSNSSRIGDLPKNEYLKKL TP 4 Homo sapiens (Human)
Q7L9B9 EEPD1
EEPD1_HUMAN
1 7 MGSTLGCHRSIPRDPSDLSH TP 1 Homo sapiens (Human)
Q6P9B6 KIAA1609
K1609_HUMAN
1 7 MGNSRSRVGRSFCSQFLPEE TP 1 Homo sapiens (Human)
Q5XIF5 Degs1
DEGS1_RAT
1 7 MGNRVSREEFEWVYTDQPHA TP 3 Rattus norvegicus (Norway rat)
Q15078 CDK5R1
CD5R1_HUMAN
1 7 MGTVLSLSPSYRKATLFEDG TP 6 Homo sapiens (Human)
Q14699 RFTN1
RFTN1_HUMAN
1 7 MGCGLNKLEKRDEKRPGNIY TP 4 Homo sapiens (Human)
Q05175 Basp1
BASP1_RAT
1 7 MGSKLSKKKKGYNVNDEKAK TP 4 Rattus norvegicus (Norway rat)
P84077 ARF1
ARF1_HUMAN
1 7 MGNIFANLFKGLFGKKEMRI TP 2 Homo sapiens (Human)
P63098 PPP3R1
CANB1_HUMAN
1 7 MGNEASYPLEMCSHFDADEI TP 3 Homo sapiens (Human)
P63096 GNAI1
GNAI1_HUMAN
1 7 MGCTLSAEDKAAVERSKMID TP 2 Homo sapiens (Human)
P56559 ARL4C
ARL4C_HUMAN
1 7 MGNISSNISAFQSLHIVMLG TP 4 Homo sapiens (Human)
P51177 GUCA1B
GUC1B_BOVIN
1 7 MGQQFSWEEAEENGAVGAAD TP 3 Bos taurus (Cattle)
P29966 MARCKS
MARCS_HUMAN
1 7 MGAQFSKTAAKGEAAAERPG TP 2 Homo sapiens (Human)
P29473 NOS3
NOS3_BOVIN
1 7 MGNLKSVGQEPGPPCGLGLG TP 3 Bos taurus (Cattle)
P08631 HCK
HCK_HUMAN
1 7 MGGRSSCEDPGCPRDEERAP TP 2 Homo sapiens (Human)
P00517 PRKACA
KAPCA_BOVIN
1 7 MGNAAAAKKGSEQESVKEFL TP 9 Bos taurus (Cattle)
O75695 RP2
XRP2_HUMAN
1 7 MGCFFSKRRKADKESRPENE TP 10 Homo sapiens (Human)
O43149 ZZEF1
ZZEF1_HUMAN
1 7 MGNAPSHSSEDEAAAAGGEG TP 1 Homo sapiens (Human)
O00408 PDE2A
PDE2A_HUMAN
1 7 MGQACGHSILCRSQQYPAAR TP 1 Homo sapiens (Human)
1 
P21457 RCVRN
RECO_BOVIN
1 7 MGNSKSGALSKEILEELQLN TP 1 Bos taurus (Cattle)
1 
P17612 PRKACA
KAPCA_HUMAN
1 7 MGNAAAAKKGSEQESVKEFL TP 3 Homo sapiens (Human)
1 
P12931 SRC
SRC_HUMAN
1 7 MGSNKSKPKDASQRRRSLEP TP 0 Homo sapiens (Human)
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement