The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
S-palmitoylation site
Functional site description:
Reversible addition of palmitate or other long chain fatty acids to protein at cysteine residues via a thioester linkage.
ELMs with same func. site: MOD_SPalmitoyl_2  MOD_SPalmitoyl_4 
ELM Description:
Class 4 palmitoylation motif. Proteins that belong to this class: Src-family kinases (all except src itself) and G-protein alpha subunits.
Pattern: ^M{0,1}G(C)..S[AKS]
Pattern Probability: 3.261e-08
Present in taxons: Canis lupus familiaris Eukaryota Gallus gallus Homo sapiens Mus musculus Rattus norvegicus
Interaction Domain:
zf-DHHC (PF01529) DHHC zinc finger domain (Stochiometry: 1 : 1)
o See 6 Instances for MOD_SPalmitoyl_4
o Abstract
The post-translational addition of palmitate to many integral and peripheral membrane proteins is the most common modification. The palmitate group promotes stable membrane association. In combination with a myristoyl or farnesyl group, palmitoylation essentially permanently anchors a protein to the membrane. The target proteins of Palmitoyl acyltransferase (PAT) can be divided in four classes: (1) transmembrane proteins, (2) prenylated proteins, (3) exclusively palmitoylated proteins, and (4) myristoylated proteins.
o 4 selected references:

o 3 GO-Terms:

o 6 Instances for MOD_SPalmitoyl_4
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
LCK_MOUSE Lck 1 7 MGCVCSSNPEDDWMENIDVC TP 2 Mus musculus (House mouse)
YES_HUMAN YES1 1 7 MGCIKSKENKSPAIKYRPEN U 0 Homo sapiens (Human)
GNAO_HUMAN GNAO1 1 7 MGCTLSAEERAALERSKAIE TP 0 Homo sapiens (Human)
LCK_HUMAN LCK 1 7 MGCGCSSHPEDDWMENIDVC TP 0 Homo sapiens (Human)
GNAZ_HUMAN GNAZ 1 7 MGCRQSSEEKEAARRSRRID TP 0 Homo sapiens (Human)
LYN_HUMAN LYN 1 7 MGCIKSKGKDSLSDDGVDLK U 0 Homo sapiens (Human)
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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