The Eukaryote Linear Motif resource for Functional Sites in Proteins
Functional site class:
SH2 ligand
Functional site description:
Src Homology 2 (SH2) domains recognize small motifs containing a phosphorylated Tyrosine residue.
ELMs with this model: LIG_SH2_GRB2  LIG_SH2_PTP2  LIG_SH2_SRC  LIG_SH2_STAT3  LIG_SH2_STAT5  LIG_SH2_STAT6 
Description:
STAT5 Src Homology 2 (SH2) domain binding motif. This is one of the most promiscuous motifs in ELM. It will match to approximately every third Tyr residue. Therefore the predictive power is very weak.
Pattern: (Y)[VLTFIC]..
Pattern Probability: 0.0032959
Present in taxons: Homo sapiens Metazoa
Interaction Domain:
SH2 (PF00017) SH2 domain (Stochiometry: 1 : 1)
o See 19 Instances for LIG_SH2_STAT5
o Abstract
Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signaling pathways. They are able to bind specific motifs containing a phopshorylated tyrosine residue, propagating the signal downstream promoting protein-protein interaction and/or modifying enzymatic activities. Different families of SH2 domains may have different binding specifity, which is usually determined by few residues C-terminal with respect to the pY (positions +1, +2 and +3. Non-phosphorylated peptides do not bind to the SH2 domains. At least three different binding motifs are known: pYEEI (Src-family SH2 domains), pY[IV].[VILP] (SH-PTP2, phospholipase C-gamma), pY.[EN] (GRB2). The interaction between SH2 domains and their substrates is however dependent also to cooperative contacts of other surface regions.
o 5 selected references:

o 2 GO-Terms:

o 19 Instances for LIG_SH2_STAT5
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
EPOR_HUMAN EPOR 426 429 GASAASFEYTILDPSSQLLR U 0 Homo sapiens (Human)
EPOR_HUMAN EPOR 368 371 GSEHAQDTYLVLDKWLLPRN U 0 Homo sapiens (Human)
GHR_HUMAN GHR 566 569 PSLNQEDIYITTESLTTAAG U 1 Homo sapiens (Human)
GHR_HUMAN GHR 627 630 KEFLSSCGYVSTDQLNKIMP U 1 Homo sapiens (Human)
GHR_HUMAN GHR 534 537 ENFLMDNAYFCEADAKKCIP U 1 Homo sapiens (Human)
PRLR_HUMAN PRLR 342 345 PSQGMKPTYLDPDTDSGRGS U 1 Homo sapiens (Human)
1 
IL3RB_HUMAN CSF2RB 628 631 SPPPGSLEYLCLPAGGQVQL U 1 Homo sapiens (Human)
IL3RB_HUMAN CSF2RB 766 769 PVKSGFEGYVELPPIEGRSP U 1 Homo sapiens (Human)
IL2RB_HUMAN IL2RB 418 421 PLSGEDDAYCTFPSRDDLLL U 0 Homo sapiens (Human)
IL7RA_HUMAN IL7R 449 452 SLGSNQEEAYVTMSSFYQNQ U 0 Homo sapiens (Human)
IL9R_HUMAN IL9R 407 410 EWRVQTLAYLPQEDWAPTSL U 0 Homo sapiens (Human)
PGFRB_HUMAN PDGFRB 751 754 MSKDESVDYVPMLDMKGDVK U 0 Homo sapiens (Human)
INSR_HUMAN INSR 1361 1364 RSYEEHIPYTHMNGGKKNGR TP 2 Homo sapiens (Human)
1 
CTLA4_MOUSE Ctla4 201 204 RSPLTTGVYVKMPPTEPECE TP 3 Mus musculus (House mouse)
1 
ERBB4_HUMAN ERBB4 1056 1059 IGHSPPPAYTPMSGNQFVYR TP 4 Homo sapiens (Human)
1 
LAT_HUMAN LAT 132 135 EDDYHNPGYLVVLPDSTPAT TP 4 Homo sapiens (Human)
GAB1_HUMAN GAB1 447 450 SSEELDENYVPMNPNSPPRQ TP 4 Homo sapiens (Human)
1 
1 
GAB1_HUMAN GAB1 472 475 TEPIQEANYVPMTPGTFDFS TP 4 Homo sapiens (Human)
1 
1 
GAB1_HUMAN GAB1 619 622 DSHDSEENYVPMNPNLSSED TP 4 Homo sapiens (Human)
1 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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