| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002573 | Q13480-2 GAB1 GAB1_HUMAN |
447 | 450 | SSEELDENYVPMNPNSPPRQ | TP | --- | Homo sapiens (Human) | 724 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0096 | pull down | in vivo/in vitro | support | likely | InteractionDetection | |
| experimental | MI:0519 | glutathione s tranferase tag | in vitro | Lehr,2000 | support | likely | |
| experimental | MI:0039 | edman degradation | in vitro | Lehr,2000 | support | likely | ParticipantIdentification |
| experimental | MI:0943 | detection by mass spectrometry | in vivo/in vitro | Lehr,2000 | support | likely | InteractionDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Lehr,2000 | support | likely | FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P27986) P85A_HUMAN | PF00017
(SH2)
SH2 domain |
[mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000704:
Phosphorylation of Y447 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement