The Eukaryote Linear Motif resource for Functional Sites in Proteins
 
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Functional site class: SH2 ligand
Functional site description: Src Homology 2 (SH2) domains recognize small motifs containing a phosphorylated Tyrosine residue
ELMs: LIG_SH2_GRB2 LIG_SH2_PTP2 LIG_SH2_SRC LIG_SH2_STAT3 LIG_SH2_STAT5 LIG_SH2_STAT6
Description: STAT5 Src Homology 2 (SH2) domain binding motif. This is one of the most promiscuous motifs in ELM. It will match to approximately every third Tyr residue. Therefore the predictive power is very weak.
Pattern: (Y)[VLTFIC].. (Probability: 0.0032959)
Present in taxons: Homo sapiens Metazoa
Interaction Domain:

SH2 (PF00017)
SH2 domain
(Stochiometry: 1 : 1)

o See 16 Instances for LIG_SH2_STAT5


o Abstract

Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signaling pathways. They are able to bind specific motifs containing a phopshorylated tyrosine residue, propagating the signal downstream promoting protein-protein interaction and/or modifying enzymatic activities. Different families of SH2 domains may have different binding specifity, which is usually determined by few residues C-terminal with respect to the pY (positions +1, +2 and +3. Non-phosphorylated peptides do not bind to the SH2 domains. At least three different binding motifs are known: pYEEI (Src-family SH2 domains), pY[IV].[VILP] (SH-PTP2, phospholipase C-gamma), pY.[EN] (GRB2). The interaction between SH2 domains and their substrates is however dependent also to cooperative contacts of other surface regions.

o 5 selected references:

o 2 GO-Terms:

o 16 Instances for LIG_SH2_STAT5
(click table headers for sorting)
SequenceStartEndSubsequence
Instance LogicPDB Organism
EPOR_HUMAN 426 429 GASAASFEYTILDPSSQLLR unknown --- Homo sapiens (Human)
EPOR_HUMAN 368 371 GSEHAQDTYLVLDKWLLPRN unknown --- Homo sapiens (Human)
GHR_HUMAN 566 569 PSLNQEDIYITTESLTTAAG unknown --- Homo sapiens (Human)
GHR_HUMAN 627 630 KEFLSSCGYVSTDQLNKIMP unknown --- Homo sapiens (Human)
GHR_HUMAN 534 537 ENFLMDNAYFCEADAKKCIP unknown --- Homo sapiens (Human)
PRLR_HUMAN 342 345 PSQGMKPTYLDPDTDSGRGS unknown --- Homo sapiens (Human)
IL3RB_HUMAN 628 631 SPPPGSLEYLCLPAGGQVQL unknown --- Homo sapiens (Human)
IL3RB_HUMAN 766 769 PVKSGFEGYVELPPIEGRSP unknown --- Homo sapiens (Human)
IL2RB_HUMAN 418 421 PLSGEDDAYCTFPSRDDLLL unknown --- Homo sapiens (Human)
IL7RA_HUMAN 449 452 SLGSNQEEAYVTMSSFYQNQ unknown --- Homo sapiens (Human)
IL9R_HUMAN 407 410 EWRVQTLAYLPQEDWAPTSL unknown --- Homo sapiens (Human)
PGFRB_HUMAN 751 754 MSKDESVDYVPMLDMKGDVK unknown --- Homo sapiens (Human)
INSR_HUMAN 1361 1364 RSYEEHIPYTHMNGGKKNGR true positive --- Homo sapiens (Human)
CTLA4_MOUSE 201 204 RSPLTTGVYVKMPPTEPECE true positive --- Mus musculus (House mouse)
ERBB4_HUMAN 1056 1059 IGHSPPPAYTPMSGNQFVYR true positive --- Homo sapiens (Human)
LAT_HUMAN 132 135 EDDYHNPGYLVVLPDSTPAT true positive --- Homo sapiens (Human)

Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)

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