LIG_SH2_STAT5
ELM server details
ELM
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Functional site class:
 SH2 ligand
Functional site description:
 Src Homology 2 (SH2) domains recognize small motifs containing a phosphorylated Tyrosine residue
ELM(s): LIG_SH2_STAT3, LIG_SH2_SRC, LIG_SH2_PTP2, LIG_SH2_GRB2, LIG_SH2_STAT5, LIG_SH2_STAT6
LIG_SH2_STAT5 description: STAT5 Src Homology 2 (SH2) domain binding motif. This is one of the most promiscuous motifs in ELM. It will match to approximately every third Tyr residue. Therefore the predictive power is very weak.
Pattern: Y[VLTFIC]..
Present in taxon(s): Metazoa  Homo sapiens  
Not represented in taxon(s):

o See instances for LIG_SH2_STAT5


o Abstract

Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signaling pathways. They are able to bind specific motifs containing a phopshorylated tyrosine residue, propagating the signal downstream promoting protein-protein interaction and/or modifying enzymatic activities. Different families of SH2 domains may have different binding specifity, which is usually determined by few residues C-terminal with respect to the pY (positions +1, +2 and +3. Non-phosphorylated peptides do not bind to the SH2 domains. At least three different binding motifs are known: pYEEI (Src-family SH2 domains), pY[IV].[VILP] (SH-PTP2, phospholipase C-gamma), pY.[EN] (GRB2). The interaction between SH2 domains and their substrates is however dependent also to cooperative contacts of other surface regions.

o Selected references

Dijkers PF, van Dijk TB, de Groot RP, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ
Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor.
Oncogene 1999 Jun 3;18(22) : 3334-42.
PMID: 10362354

Hansen LH, Wang X, Kopchick JJ, Bouchelouche P, Nielsen JH, Galsgaard ED, Billestrup N
Identification of tyrosine residues in the intracellular domain of the growth hormone receptor required for transcriptional signaling and Stat5 activation.
J Biol Chem 1996 May 24;271(21) : 12669-73.
PMID: 8647880

Lebrun JJ, Ali S, Goffin V, Ullrich A, Kelly PA
A single phosphotyrosine residue of the prolactin receptor is responsible for activation of gene transcription.
Proc Natl Acad Sci U S A 1995 Apr 25;92(9) : 4031-5.
PMID: 7537382

Wang X, Darus CJ, Xu BC, Kopchick JJ
Identification of growth hormone receptor (GHR) tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activation.
Mol Endocrinol 1996 Oct;10(10) : 1249-60.
PMID: 9121492

van Dijk TB, Caldenhoven E, Raaijmakers JA, Lammers JW, Koenderman L, de Groot RP
Multiple tyrosine residues in the intracellular domain of the common beta subunit of the interleukin 5 receptor are involved in activation of STAT5.
FEBS Lett 1997 Jul 21;412(1) : 161-4.
PMID: 9257712

o This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.

Biological Process
Cellular Component
  cytosol
Molecular Function
  SH2-domain binding

 

o Instances for LIG_SH2_STAT5

SequencePositionSubsequence
(Click for evidence information)		PDBGene NameProtein DescriptionOrganism
EPOR_HUMAN 368-371 HAQDTYLVLDKWLLP - Name=EPOR; Erythropoietin receptor precursor (EPO-R). Homo sapiens (Human).
EPOR_HUMAN 426-429 AASFEYTILDPSSQL - Name=EPOR; Erythropoietin receptor precursor (EPO-R). Homo sapiens (Human).
GHR_HUMAN 534-537 LMDNAYFCEADAKKC - Name=GHR; Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]. Homo sapiens (Human).
GHR_HUMAN 566-569 NQEDIYITTESLTTA - Name=GHR; Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]. Homo sapiens (Human).
GHR_HUMAN 627-630 LSSCGYVSTDQLNKI - Name=GHR; Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]. Homo sapiens (Human).
PRLR_HUMAN 342-345 GMKPTYLDPDTDSGR - Name=PRLR; Prolactin receptor precursor (PRL-R). Homo sapiens (Human).
IL3RB_HUMAN 628-631 PGSLEYLCLPAGGQV - Name=CSF2RB; Synonyms=IL3RB, IL5RB; Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). Homo sapiens (Human).
IL3RB_HUMAN 766-769 SGFEGYVELPPIEGR - Name=CSF2RB; Synonyms=IL3RB, IL5RB; Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). Homo sapiens (Human).
IL2RB_HUMAN 418-421 GEDDAYCTFPSRDDL - Name=IL2RB; Interleukin-2 receptor subunit beta precursor (IL-2 receptor) (P70-75) (p75) (High affinity IL-2 receptor subunit beta) (CD122 antigen). Homo sapiens (Human).
IL7RA_HUMAN 449-452 NQEEAYVTMSSFYQN - Name=IL7R; Interleukin-7 receptor alpha chain precursor (IL-7R-alpha) (CD127 antigen) (CDw127). Homo sapiens (Human).
IL9R_HUMAN 407-410 VQTLAYLPQEDWAPT - Name=IL9R; Interleukin-9 receptor precursor (IL-9R) (CD129 antigen). Homo sapiens (Human).
PGFRB_HUMAN 751-754 DESVDYVPMLDMKGD 1PIC
 Name=PDGFRB; Beta-type platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen). Homo sapiens (Human).