Accession: | |
---|---|
Functional site class: | TYR phosphorylation site |
Functional site description: | Protein tyrosine kinases (PTKs) catalyze the transfer of the gamma-phosphate of ATP to tyrosine residues of protein substrates. |
ELMs with same func. site: | MOD_TYR_CSK MOD_TYR_DYR |
ELM Description: | The kinase activity of the DYRK (dual specificity kinase) is dependent on the autophosphorylation of the YXY motif in the activation loop. |
Pattern: | ..[RKTC][IVL]Y[TQHS](Y)[IL]QSR |
Pattern Probability: | 5.207e-11 |
Present in taxon: | Eukaryota |
Interaction Domain: |
Pkinase (PF00069)
Protein kinase domain
(Stochiometry: 1 : 1)
|
Abstract |
Protein-tyrosine kinases (PTKs) are essential regulators of intracellular signal-transduction pathways in eukaryotes. Tyrosine phosphorylation plays an important role in the control of several cellular processes such as cell proliferation, cell migration, differentiation, immune response, and cell cycle. Their activity is normally tight control and regulated. Perturbation of the PTK signaling by mutation and other genetic alterations result in deregulated kinase activity and malignant transformation. The mechanism of substrate recognition by the PTKs has been one of the major challenges in phosphorylation research over the years. Peptide library approaches have provided some insight about the role of amino acid immediately surrounding Tyr phosphorylation sites and it has been shown that the specificity of PTKs is dominated by acidic or hydrophobic residues adjacent to the phosphorylated residue (Songyang,1999). Based on a larger set of experimentally verified phosphorylation sites, it was found that some amino acids were not present in some positions, e.g. tryptophan was never found in position -5 to -1. Similarly, cysteine was never found at position -2 and -1, while methionine was always absent in position -2 (Blom,2000). Recently, numerous studies have revealed that the local amino acid sequence is certainly not the sole determinant of substrate specificity but other several factor, including local structure, protein-protein interaction and surface accessibility, also play a main role. |
5 GO-Terms:
9 Instances for MOD_TYR_DYR
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, Name | Start | End | Subsequence | Logic | #Ev. | Organism | Notes |
---|---|---|---|---|---|---|---|
Q09815 ppk5 PPK5_SCHPO |
672 | 682 | SCFYNEKVYTYLQSRFYRAP | TP | 1 | Schizosaccharomyces pombe (Fission yeast) | |
Q09690 pom1 POM1_SCHPO |
853 | 863 | SCFEGECVYTYIQSRFYRSP | TP | 1 | Schizosaccharomyces pombe (Fission yeast) | |
Q13627 DYRK1A DYR1A_HUMAN |
315 | 325 | SCQLGQRIYQYIQSRFYRSP | TP | 1 | Homo sapiens (Human) | |
Q61214 Dyrk1a DYR1A_MOUSE |
315 | 325 | SCQLGQRIYQYIQSRFYRSP | TP | 1 | Mus musculus (House mouse) | |
P83102 Dyrk3 DYRK3_DROME |
430 | 440 | SCFENQRIYTYIQSRFYRAP | TP | 1 | Drosophila melanogaster (Fruit fly) | |
Q9Y463 DYRK1B DYR1B_HUMAN |
267 | 277 | SCQLGQRIYQYIQSRFYRSP | TP | 1 | Homo sapiens (Human) | |
Q9Z188 Dyrk1b DYR1B_MOUSE |
267 | 277 | SCQLGQRIYQYIQSRFYRSP | TP | 1 | Mus musculus (House mouse) | |
Q63470 Dyrk1a DYR1A_RAT |
315 | 325 | SCQLGQRIYQYIQSRFYRSP | TP | 2 | Rattus norvegicus (Norway rat) | |
P14680 YAK1 YAK1_YEAST |
524 | 534 | SCEEARTVYTYIQSRFYRAP | TP | 3 | Saccharomyces cerevisiae (Baker"s yeast) |
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement