The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
PTS2
Functional site description:
PTS2 is a signal placed toward the N-terminus of some proteins that are directed to the peroxisomal matrix
ELM Description:
Generic PTS2 pattern for all eukaryotes (except lineages which have lost it)
Pattern: ^.{1,40}R[^P][^P][^P][LIV][^P][^P][HQ][LIF]
Pattern Probability: 0.0000039
Present in taxon: Eukaryota
Not represented in taxon: Caenorhabditis elegans
Interaction Domain:
WD40 (PF00400) WD domain, G-beta repeat (Stochiometry: 1 : 1)
PDB Structure: 1F2J
<a href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1F2J" title="" target="_blank"><img src="/media/pdb.ico.png"/>1F2J</a>
o See 2 Instances for TRG_PTS2
o Abstract
PTS2, peroxisomal targeting signal 2, is one of two peroxisomal import signals which direct proteins into the lumen (matrix) of the peroxisome.
(The other being PTS1.) A third signal is used to target peroxisomal membrane proteins. PTS2 is found less often than PTS1 and has been lost in
the lineage leading to Ceanorhabditis elegans (and perhaps other nematodes too).
o 6 GO-Terms:

o 2 Instances for TRG_PTS2
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
ALF_TRYBB ALD 1 12 MSKRVEVLLTQLPAYNRLKT TP 1 Trypanosoma brucei brucei
Q9U5N6_LEIME ald 1 11 MSRVTVLQSQLPAYNRLKTP TP 1 Leishmania mexicana
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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