The Eukaryote Linear Motif resource for Functional Sites in Proteins
TRG_ENDOCYTIC_2 120
 
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Functional site class: Y-based sorting signal
Functional site description: Yxxphi sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex
ELMs: TRG_ENDOCYTIC_2
Description: Tyrosine-based sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex
Pattern: Y..[LMVIF] (Probability: 0.0025875)
Present in taxons: Eukaryota Homo sapiens Mus musculus Rattus norvegicus Saccharomyces cerevisiae
PDB Structure: 1BXX
<img src="/media/pdb.ico.png"/><a href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1BXX" target="_blank">1BXX</a>
Interaction Domain:

Adap_comp_sub (PF00928)
Adaptor complexes medium subunit family
(Stochiometry: 1 : 1)

o See 15 Instances for TRG_ENDOCYTIC_2


o Abstract

Intracellular traffic of many membrane-bound proteins requires sequences facing the cytoplasm. In many instances the sorting information is encoded in short peptide motifs, typically 4-6 amino acids, which are referred to as sorting signals. These motifs determine which vescicular traffic pathway is used to transport a particular molecule and hence determine its final destination. The Yxxphi motif is a sorting signal found in the cytosolic tail of various membrane proteins as an endocytic motif and also directs traffic within the endosomal and the secretory pathways. The Yxxphi motif interacts with mu subunit of AP (Adaptor Protein) complex.

o 9 selected references:

o 7 GO-Terms:

o 15 Instances for TRG_ENDOCYTIC_2
(click table headers for sorting)
SequenceStartEndSubsequence
Instance LogicPDB Organism
EGFR_HUMAN 998 1001 PSPTDSNFYRALMDEEDMDD true positive --- Homo sapiens (Human)
CTLA4_HUMAN 201 204 RSPLTTGVYVKMPPTEPECE true positive --- Homo sapiens (Human)
L1CAM_HUMAN 1176 1179 MKDETFGEYRSLESDNEEKA true positive --- Homo sapiens (Human)
TGON3_RAT 350 353 RSKVTRRPKASDYQRLNLKL true positive 1BXX
 Rattus norvegicus (Norway rat)
ASGR1_HUMAN 5 8 MTKEYQDLQHLDNEESDHHQ true positive --- Homo sapiens (Human)
LAMP1_HUMAN 414 417 IVLIAYLVGRKRSHAGYQTI true positive --- Homo sapiens (Human)
ENV_BLV 487 490 FPPKPDSDYQALLPSAPEIY unknown --- Bovine leukemia virus
ENV_HTLV2 477 480 PQRLQNRHNQYSLINPETML true positive --- Human T-lymphotropic virus 2
VGLG_VSIVA 501 504 LKHTKKRQIYTDIEMNRLGK unknown --- Vesicular stomatitis Indiana virus strain San Juan
ENV_SIVMK 723 726 MLAKLRQGYRPVFSSPPSYF true positive --- Simian immunodeficiency virus - mac K6W
GE_VZVO 582 585 SPYNQSMYYAGLPVDDFEDS true positive --- Human herpesvirus 3 strain Oka vaccine
CTLA4_MOUSE 201 204 RSPLTTGVYVKMPPTEPECE true positive --- Mus musculus (House mouse)
TFR1_HUMAN 20 23 LFGGEPLSYTRFSLARQVDG true positive --- Homo sapiens (Human)
PPAL_HUMAN 413 416 FRMQAQPPGYRHVADGEDHA true positive --- Homo sapiens (Human)
ENV_HV1H2 712 715 IVNRVRQGYSPLSFQTHLPT true positive --- HIV-1 M:B_HXB2R

Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)

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