The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
Y-based sorting signal
Functional site description:
Yxxphi sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex
ELM Description:
Tyrosine-based sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex
Pattern: Y..[LMVIF]
Pattern Probability: 0.0025875
Present in taxons: Eukaryota Homo sapiens Mus musculus Rattus norvegicus Saccharomyces cerevisiae
Interaction Domain:
Adap_comp_sub (PF00928) Adaptor complexes medium subunit family (Stochiometry: 1 : 1)
PDB Structure: 1BXX
<a href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1BXX" title="" target="_blank"><img src="/media/pdb.ico.png"/>1BXX</a>
o See 15 Instances for TRG_ENDOCYTIC_2
o Abstract
Intracellular traffic of many membrane-bound proteins requires sequences facing the cytoplasm. In many instances the sorting information is encoded in short peptide motifs, typically 4-6 amino acids, which are referred to as sorting signals. These motifs determine which vescicular traffic pathway is used to transport a particular molecule and hence determine its final destination. The Yxxphi motif is a sorting signal found in the cytosolic tail of various membrane proteins as an endocytic motif and also directs traffic within the endosomal and the secretory pathways. The Yxxphi motif interacts with mu subunit of AP (Adaptor Protein) complex.
o 9 selected references:

o 7 GO-Terms:

o 15 Instances for TRG_ENDOCYTIC_2
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P04578 env
ENV_HV1H2
712 715 IVNRVRQGYSPLSFQTHLPT TP 6 HIV-1 M:B_HXB2R
1 
P11117 ACP2
PPAL_HUMAN
413 416 FRMQAQPPGYRHVADGEDHA TP 5 Homo sapiens (Human)
1 
P02786 TFRC
TFR1_HUMAN
20 23 LFGGEPLSYTRFSLARQVDG TP 1 Homo sapiens (Human)
1 
P09793 Ctla4
CTLA4_MOUSE
201 204 RSPLTTGVYVKMPPTEPECE TP 4 Mus musculus (House mouse)
1 
Q9J3M8 gE
GE_VZVO
582 585 SPYNQSMYYAGLPVDDFEDS TP 4 Human herpesvirus 3 strain Oka vaccine
1 
P05884 env
ENV_SIVMK
723 726 MLAKLRQGYRPVFSSPPSYF TP 2 Simian immunodeficiency virus - mac K6W
1 
P03522 G
VGLG_VSIVA
501 504 LKHTKKRQIYTDIEMNRLGK U 1 Vesicular stomatitis Indiana virus strain San Juan
1 
P03383 env
ENV_HTLV2
477 480 PQRLQNRHNQYSLINPETML TP 2 Human T-lymphotropic virus 2
1 
P51519 env
ENV_BLV
487 490 FPPKPDSDYQALLPSAPEIY U 1 Bovine leukemia virus
1 
P11279 LAMP1
LAMP1_HUMAN
414 417 IVLIAYLVGRKRSHAGYQTI TP 0 Homo sapiens (Human)
1 
P07306 ASGR1
ASGR1_HUMAN
5 8 MTKEYQDLQHLDNEESDHHQ TP 0 Homo sapiens (Human)
1 
P19814 Ttgn1
TGON3_RAT
350 353 RSKVTRRPKASDYQRLNLKL TP 1 Rattus norvegicus (Norway rat)
1 
P32004 L1CAM
L1CAM_HUMAN
1176 1179 MKDETFGEYRSLESDNEEKA TP 0 Homo sapiens (Human)
4 
P16410 CTLA4
CTLA4_HUMAN
201 204 RSPLTTGVYVKMPPTEPECE TP 0 Homo sapiens (Human)
1 
P00533 EGFR
EGFR_HUMAN
998 1001 PSPTDSNFYRALMDEEDMDD TP 0 Homo sapiens (Human)
1 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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