The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
Y-based sorting signal
Functional site description:
Yxxphi sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex
ELM Description:
Tyrosine-based sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex
Pattern: Y..[LMVIF]
Pattern Probability: 0.0025875
Present in taxons: Eukaryota Homo sapiens Mus musculus Rattus norvegicus Saccharomyces cerevisiae
Interaction Domain:
Adap_comp_sub (PF00928) Adaptor complexes medium subunit family (Stochiometry: 1 : 1)
PDB Structure: 1BXX
<a href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1BXX" title="" target="_blank"><img src="/media/pdb.ico.png"/>1BXX</a>
o See 15 Instances for TRG_ENDOCYTIC_2
o Abstract
Intracellular traffic of many membrane-bound proteins requires sequences facing the cytoplasm. In many instances the sorting information is encoded in short peptide motifs, typically 4-6 amino acids, which are referred to as sorting signals. These motifs determine which vescicular traffic pathway is used to transport a particular molecule and hence determine its final destination. The Yxxphi motif is a sorting signal found in the cytosolic tail of various membrane proteins as an endocytic motif and also directs traffic within the endosomal and the secretory pathways. The Yxxphi motif interacts with mu subunit of AP (Adaptor Protein) complex.
o 9 selected references:

o 7 GO-Terms:

o 15 Instances for TRG_ENDOCYTIC_2
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
ENV_HV1H2 env 712 715 IVNRVRQGYSPLSFQTHLPT TP 6 HIV-1 M:B_HXB2R
1 
PPAL_HUMAN ACP2 413 416 FRMQAQPPGYRHVADGEDHA TP 5 Homo sapiens (Human)
1 
TFR1_HUMAN TFRC 20 23 LFGGEPLSYTRFSLARQVDG TP 1 Homo sapiens (Human)
1 
CTLA4_MOUSE Ctla4 201 204 RSPLTTGVYVKMPPTEPECE TP 4 Mus musculus (House mouse)
1 
GE_VZVO gE 582 585 SPYNQSMYYAGLPVDDFEDS TP 4 Human herpesvirus 3 strain Oka vaccine
1 
ENV_SIVMK env 723 726 MLAKLRQGYRPVFSSPPSYF TP 2 Simian immunodeficiency virus - mac K6W
1 
VGLG_VSIVA G 501 504 LKHTKKRQIYTDIEMNRLGK U 1 Vesicular stomatitis Indiana virus strain San Juan
1 
ENV_HTLV2 env 477 480 PQRLQNRHNQYSLINPETML TP 2 Human T-lymphotropic virus 2
1 
ENV_BLV env 487 490 FPPKPDSDYQALLPSAPEIY U 1 Bovine leukemia virus
1 
LAMP1_HUMAN LAMP1 414 417 IVLIAYLVGRKRSHAGYQTI TP 0 Homo sapiens (Human)
1 
ASGR1_HUMAN ASGR1 5 8 MTKEYQDLQHLDNEESDHHQ TP 0 Homo sapiens (Human)
1 
TGON3_RAT Ttgn1 350 353 RSKVTRRPKASDYQRLNLKL TP 1 Rattus norvegicus (Norway rat)
1 
L1CAM_HUMAN L1CAM 1176 1179 MKDETFGEYRSLESDNEEKA TP 0 Homo sapiens (Human)
4 
CTLA4_HUMAN CTLA4 201 204 RSPLTTGVYVKMPPTEPECE TP 0 Homo sapiens (Human)
1 
EGFR_HUMAN EGFR 998 1001 PSPTDSNFYRALMDEEDMDD TP 0 Homo sapiens (Human)
1 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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