The Eukaryote Linear Motif resource for Functional Sites in Proteins
MOD_SPalmitoyl_2 175
 
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Functional site class: S-palmitoylation site
Functional site description: Reversible addition of palmitate or other long chain fatty acids to protein at cysteine residues via a thioester linkage
ELMs: MOD_SPalmitoyl_2 MOD_SPalmitoyl_4
Description: Class 2 Palmitoylation motif. Proteins that belong to this class: Ras proteins (H-Ras, N-Ras).
Pattern: G(C)M[GS][CL][KP]C (Probability: 0.0000000)
Present in taxons: Eukaryota Homo sapiens
Interaction Domain:

zf-DHHC (PF01529)
DHHC zinc finger domain
(Stochiometry: 1 : 1)

o See 2 Instances for MOD_SPalmitoyl_2


o Abstract

The post-translational addition of palmitate to many integral and peripheral membrane proteins is the most common modification. Palmitate group promotes stable membrane association. In combination with a myristoyl or farnesyl group, palmitoylated proteins are essentially permanently anchored to the membrane.

The target proteins of Palmitoyl acyltransferase (PAT) can be divided in four classes: (1) transmembrane proteins, (2) prenylated proteins, (3) exclusively palmitoylated proteins, (4) myristoylated proteins.

o 4 selected references:

o 3 GO-Terms:

o 2 Instances for MOD_SPalmitoyl_2
(click table headers for sorting)
SequenceStartEndSubsequence
LogicPDB Organism
(P01112)
RASH_HUMAN 		180 186 KLNPPDESGPGCMSCKCVLS TP --- Homo sapiens (Human)
(P01111)
RASN_HUMAN 		180 186 KLNSSDDGTQGCMGLPCVVM TP --- Homo sapiens (Human)

Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)

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