The Eukaryote Linear Motif resource for Functional Sites in Proteins
Functional site class:
S-palmitoylation site
Functional site description:
Reversible addition of palmitate or other long chain fatty acids to protein at cysteine residues via a thioester linkage.
ELMs with this model: MOD_SPalmitoyl_2  MOD_SPalmitoyl_4 
Description:
Class 2 Palmitoylation motif. Proteins that belong to this class: Ras proteins (H-Ras, N-Ras).
Pattern: G(C)M[GS][CL][KP]C
Pattern Probability: 3.052e-10
Present in taxons: Eukaryota Homo sapiens
Interaction Domain:
zf-DHHC (PF01529) DHHC zinc finger domain (Stochiometry: 1 : 1)
o See 2 Instances for MOD_SPalmitoyl_2
o Abstract
The post-translational addition of palmitate to many integral and peripheral membrane proteins is the most common modification. The palmitate group promotes stable membrane association. In combination with a myristoyl or farnesyl group, palmitoylation essentially permanently anchors a protein to the membrane. The target proteins of Palmitoyl acyltransferase (PAT) can be divided in four classes: (1) transmembrane proteins, (2) prenylated proteins, (3) exclusively palmitoylated proteins, and (4) myristoylated proteins.
o 4 selected references:

o 3 GO-Terms:

o 2 Instances for MOD_SPalmitoyl_2
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
RASH_HUMAN HRAS 180 186 KLNPPDESGPGCMSCKCVLS TP 1 Homo sapiens (Human)
RASN_HUMAN NRAS 180 186 KLNSSDDGTQGCMGLPCVVM TP 1 Homo sapiens (Human)
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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