The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
Immunoreceptor tyrosine-based motif
Functional site description:
In the cytoplasmatic region of immunoreceptors there are motifs that are critical for the activation and termination of signal transduction pathways.
ELMs with same func. site: LIG_TYR_ITAM  LIG_TYR_ITIM  LIG_TYR_ITSM 
ELM Description:
ITSM (immunoreceptor tyrosine-based switch motif). This motif is present in the cytoplasmic region of the CD150 subfamily within the CD2 family and it enables these receptors to bind to and to be regulated by SH2 adaptor molecules, as SH2DIA.
Pattern: ..T.(Y)..[IV]
Pattern Probability: 0.0000609
Present in taxon: Vertebrata
Interaction Domain:
SH2 (PF00017) SH2 domain (Stochiometry: 1 : 1)
o See 12 Instances for LIG_TYR_ITSM
o Abstract
Antigen recognition and communication among cells (T, B and natural killer cells) of the immune system are regulated at the level of cell-surface antigen and transmembrane receptors. The extracellular regions of these receptors provide the immune specificity, whereas the intracellular region interacts with cytoplasmatic signaling molecules that are critical for the activation and termination of signal transduction pathways. The initial signaling events following the engagement of antigen receptors are regulated by the phosphorylation of characteristic signaling motifs that coordinate the activity of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPases), and thus regulate the activation or inhibition of the intracellular response. Some receptors like CD154, CD28, CD3 transmit mainly positive co-stimulatory signals, whereas others, such as CTLA-4 killer inhibitory receptors (KIRs) or leukocyte immunoglobulin-like receptors (LIRs), function principally as inhibitory receptors. In addition, a group of dual-function receptors, such as the CD150 subfamily within the CD2 family, can either act as positive or negative regulators.
o 2 selected references:

o 2 GO-Terms:

o 12 Instances for LIG_TYR_ITSM
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
OX1R_HUMAN HCRTR1 79 86 RNHHMRTVTNYFIVNLSLAD TP 3 Homo sapiens (Human)
2 
CD244_HUMAN CD244 313 320 PTSQEPAYTLYSLIQPSRKS TP 1 Homo sapiens (Human)
CD244_HUMAN CD244 338 345 NHSPSFNSTIYEVIGKSQPK TP 1 Homo sapiens (Human)
CD244_HUMAN CD244 267 274 ETSPKEFLTIYEDVKDLKTR TP 1 Homo sapiens (Human)
LY9_HUMAN LY9 622 629 SQKEESSATIYCSIRKPQVV TP 1 Homo sapiens (Human)
SLAF5_HUMAN CD84 312 319 PSKEEPVNTVYSEVQFADKM TP 1 Homo sapiens (Human)
SLAF7_HUMAN SLAMF7 300 307 ILKEDPANTVYSTVEIPKKM TP 1 Homo sapiens (Human)
SLAF7_HUMAN SLAMF7 280 287 ICPHSGENTEYDTIPHTNRT TP 1 Homo sapiens (Human)
1 
LY9_HUMAN LY9 599 606 VESVVGENTMYAQVFNLQGK TP 1 Homo sapiens (Human)
SLAF5_HUMAN CD84 275 282 NPYAASKKTIYTYIMASRNT TP 1 Homo sapiens (Human)
SLAF1_HUMAN SLAMF1 323 330 ESVQETNSITVYASVTLPES TP 1 Homo sapiens (Human)
1 
SLAF1_HUMAN SLAMF1 277 284 TTVEKKSLTIYAQVQKPGPL TP 1 Homo sapiens (Human)
1 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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