TRG_ENDOCYTIC_2

Intracellular traffic of many membrane-bound proteins requires sequences facing the cytoplasm. In many instances the sorting information is encoded in short peptide motifs, typically 4-6 amino acids, which are referred to as sorting signals. These motifs determine which vescicular traffic pathway is used to transport a particular molecule and hence determine its final destination. The Yxxphi motif is a sorting signal found in the cytosolic tail of various membrane proteins as an endocytic motif and also directs traffic within the endosomal and the secretory pathways. The Yxxphi motif interacts with mu subunit of AP (Adaptor Protein) complex.