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| Functional site class: | Y-based sorting signal |
| Functional site description: | Yxxphi sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex |
|---|---|
| ELMs: | TRG_ENDOCYTIC_2 |
| Description: | Tyrosine-based sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex |
| Pattern: | Y..[LMVIF] (Probability: 0.0025875) |
| Present in taxons: | Eukaryota Homo sapiens Mus musculus Rattus norvegicus Saccharomyces cerevisiae |
PDB Structure: 1BXX
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| Interaction Domain: |
Adap_comp_sub (PF00928) |
See 13 Instances for TRG_ENDOCYTIC_2
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| Intracellular traffic of many membrane-bound proteins requires sequences facing the cytoplasm. In many instances the sorting information is encoded in short peptide motifs, typically 4-6 amino acids, which are referred to as sorting signals. These motifs determine which vescicular traffic pathway is used to transport a particular molecule and hence determine its final destination. The Yxxphi motif is a sorting signal found in the cytosolic tail of various membrane proteins as an endocytic motif and also directs traffic within the endosomal and the secretory pathways. The Yxxphi motif interacts with mu subunit of AP (Adaptor Protein) complex. |
9 selected references:
7 GO-Terms:
13 Instances for TRG_ENDOCYTIC_2
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