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Functional site class: SH2 ligand
Functional site description: Src Homology 2 (SH2) domains recognize small motifs containing a phosphorylated Tyrosine residue
ELMs: LIG_SH2_GRB2 LIG_SH2_PTP2 LIG_SH2_SRC LIG_SH2_STAT3 LIG_SH2_STAT5 LIG_SH2_STAT6
Description: YXXQ motif found in the cytoplasmic region of cytokine receptors that bind STAT3 SH2 domain; a cytokine receptor might contain more YXXQ motif in its cytoplasmic region.
Pattern: (Y)..Q (Probability: 0.0007975)
Present in taxons: Homo sapiens Metazoa
Interaction Domain:

SH2 (PF00017)
SH2 domain
(Stochiometry: 1 : 1)

o See 9 Instances for LIG_SH2_STAT3


o Abstract

Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signaling pathways. They are able to bind specific motifs containing a phopshorylated tyrosine residue, propagating the signal downstream promoting protein-protein interaction and/or modifying enzymatic activities. Different families of SH2 domains may have different binding specifity, which is usually determined by few residues C-terminal with respect to the pY (positions +1, +2 and +3. Non-phosphorylated peptides do not bind to the SH2 domains. At least three different binding motifs are known: pYEEI (Src-family SH2 domains), pY[IV].[VILP] (SH-PTP2, phospholipase C-gamma), pY.[EN] (GRB2). The interaction between SH2 domains and their substrates is however dependent also to cooperative contacts of other surface regions.

o 6 selected references:

o 2 GO-Terms:

o 9 Instances for LIG_SH2_STAT3
(click table headers for sorting)
SequenceStartEndSubsequence
LogicPDB Organism
(Q99062)
CSF3R_HUMAN
727 730 GLPTLVQTYVLQGDPRAVST TP --- Homo sapiens (Human)
(P40238)
TPOR_HUMAN
631 634 CCTTHIANHSYLPLSYWQQP U --- Homo sapiens (Human)
(P40223)
CSF3R_MOUSE
728 731 SLPALVQAYVLQGDPREISN U --- Mus musculus (House mouse)
(P48356)
LEPR_MOUSE
1138 1141 TSGENFVPYMPQFQTCSTHS U --- Mus musculus (House mouse)
(P40189)
IL6RB_HUMAN
767 770 YSTVVHSGYRHQVPSVQVFS U --- Homo sapiens (Human)
(P40189)
IL6RB_HUMAN
814 817 DGILPRQQYFKQNCSQHESS U --- Homo sapiens (Human)
(P40189)
IL6RB_HUMAN
905 908 TDEGMPKSYLPQTVRQGGYM U --- Homo sapiens (Human)
(P40189)
IL6RB_HUMAN
915 918 EGMPKSYLPQTVRQGGYMPQ U --- Homo sapiens (Human)
(P25049)
TIP_SHV24
72 75 NVNIQTSTYLPQNAATNLNS TP --- Herpesvirus saimiri (strain 484-77)

Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)

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